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Prevention and Treatment of Friend Leukemia Virus (FLV) Infection by Interferon-Inducing Synthetic Polyanions

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The Reticuloendothelial System and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1))

Abstract

Divinyl ether maleic anhydride (MA) copolymers (pyran copolymer, NSC 46015) inhibits Friend leukemia virus (FLV) splenomegaly. Pyran copolymer induces interferon in normal mice and the decreases in splenic FLV titers seen following pretreatment with these polyanions might be explained by the appearance of interferon. In vivo inhibition of FLV splenomegaly has also been obtained by statolon, an anionic polysaccharide, and the plant lectin, phytohemagglutinin, both of which have been reported to induce interferon. Similar inhibition of FLV splenomegaly has also been seen for methyl vinyl ether/MA and styrene/MA copolymers. Pyran copolymer is currently undergoing clinical trial in man. Its animal and human pharmacology indicates uptake in the nucleated formed elements of the blood, and stimulation of reticuloendothelial activity in liver, spleen, and bone marrow.

This work was accomplished with the support of USPHS grants CY-3887, C-5834, and C-2821, and the technical assistance of O. Foltyn in our laboratory. We wish to thank W.J. Kleinschmidt, Lilly Research Laboratories, for interferon assays. Statistical evaluation of data was done with the help of Roger L. Priore, Sc. D., of the Department of Biostatistics, Roswell Park Memorial Institute, Buffalo, New York.

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Author information

Author notes

  1. W. Regelson (Professor, Chief)

    Present address: Division of Medical Oncology, Medical College of Virginia, Richmond, Virginia, 23219, USA

Authors and Affiliations

  1. Department of Medicine A, Roswell Park Memorial Institute, Buffalo, New York, USA

    W. Regelson (Professor, Chief)

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  1. W. Regelson
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Editors and Affiliations

  1. Department of Physiology and Biophysics, University of Tennessee Medical Units, Memphis, Tennessee, USA

    Nicholas R. Di Luzio (President) (President)

  2. Institute of Pharmacology, University of Milan, Milan, Italy

    Rodolfo Paoletti

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© 1967 Springer Science+Business Media New York

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Regelson, W. (1967). Prevention and Treatment of Friend Leukemia Virus (FLV) Infection by Interferon-Inducing Synthetic Polyanions. In: Luzio, N.R.D., Paoletti, R. (eds) The Reticuloendothelial System and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7796-2_29

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  • DOI: https://doi.org/10.1007/978-1-4684-7796-2_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7798-6

  • Online ISBN: 978-1-4684-7796-2

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