Abstract
Numerous investigations have been carried out employing in vitro studies to characterize the change in biochemical activities of phagocytes subsequent to particle uptake. Sbarra and Karnovsky [1] reported that following ingestion of polystyrene spherules, polymorphonuclear cells (PMN) doubled their rate of oxygen uptake during a 60-min incubation period. Oren et al. [2] reported that guinea pig peritoneal macrophages (PM) exhibited a tripling of their rate of oxygen uptake in a similar experiment. In contrast, they also observed that guinea pig alveolar macrophages (AM) did not appreciably demonstrate an increased rate of oxygen uptake 60 min after phagocytizing polystyrene spherules.
This study was supported by research grant AI-05667 from the National Institutes of Health, USPHS, Bethesda, Maryland.
Trainee on USPHS Training Grant T1 AI 268.
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References
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Myrvik, Q.N., Evanst, D.G. (1967). Effect of Bacillus Calmette Guerin on the Metabolism of Alveolar Macrophages. In: Luzio, N.R.D., Paoletti, R. (eds) The Reticuloendothelial System and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7796-2_19
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DOI: https://doi.org/10.1007/978-1-4684-7796-2_19
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