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Reinstatement of Ovarian Cycles in Aged Female Rats by Placement of L-Dopa in the Medial Preoptic Area

  • Chapter
Pharmacological Intervention in the Aging Process

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 97))

  • 78 Accesses

Abstract

Systemic treatment with the catecholamine precursor 1-dopa has been shown to reinstate ovarian cycles in the aged female rat (Quadri et al., 1973; Linnoila and Cooper, 1976). In an effort to determine if this effect is mediated via the action of 1-dopa on CNS catecholamines, we observed ovarian function after placing small amounts of 1-dopa directly into selected brain regions of aged rats (14 to 22 months old) bearing chronically implanted cannulae. Ovarian cycles could be reliably reinstated when 1-dopa was placed in the medial preoptic area of constant estrus or recurrently pseudopregnant females. This treatment was more effective (i.e. greater proportion of females responding.) and of longer duration (i.e. greater number of cycles observed) in 14–16 month old females than in the 22 month old females. Placement of 1-dopa in the septum, hippocampus or cortex had no effect on ovarian function. Placement of the norepinephrine precursor dlthreo-dihydroxyphenylserine (DOPS) or the neutral amino acid leucine in the four brain regions was without effect on ovarian function. The results will be discussed in terms of possible regional changes in brain amines with age.

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Author information

Authors and Affiliations

  1. Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Ralph L. Cooper, Steven Brandt & Markku Linnoila

  2. Department of Pharmacology, Medical College of Pennsylvania, Philadelphia, Pennsylvania, 19129, USA

    Louise H. Greenberg, Robert K. Dix, Benjamin Weiss, Bryon N. de Sousa, Z. V. Kendrick, Jay Roberts, Steven I. Baskin, Edward M. Cohen, Paula B. Goldberg & Sallie-Ann Stoner

  3. Basic Medical Research Department SANDOZ LTD., Basel, CH-4002, Basel, Switzerland

    K. Reichlmeier, A. Enz, P. Iwangoff & W. Meier-Ruge

  4. Division of Drug Biology, Food and Drug Administration, Washington, D. C., 20204, USA

    L. R. Weiss & S. Krop

  5. Fels Research Institute and Departments of Biochemistry and Medicine, Temple University School of Medicine, USA

    Thomas L. Klug & Richard C. Adelman

  6. Department of Surgery (Division of Urology), West Virginia University Medical Center, Morgantown, West Virginia, 26506, USA

    C. Lee Robinette

  7. Departments of Pharmacology and Surgery (Division of Urology), West Virginia University Medical Center, Morgantown, West Virginia, 26506, USA

    Michael G. Mawhinney

  8. Department of Microbiology and Fels Research Institute, Temple Medical School, Philadelphia, PA, 19140, USA

    Cynthia J. Moore & Arthur G. Schwartz

  9. Biology Department, Syracuse University, Syracuse, New York, 13210, USA

    R. N. Sorrentino & J. R. Florini

  10. Gerontology Research Center, National Institute on Aging, Baltimore City Hospitals, Baltimore, Maryland, 21224, USA

    D. D. Schocken & G. S. Roth

  11. Research Service, Veterans Administration Hospital, Bedford, Massachusetts, 01730, USA

    P. J. Gill & D. M. Hanson

  12. Department of Biochemistry Boston, University School of Medicine, Boston, Massachusetts, 02118, USA

    D. M. Hanson

  13. Sinclair Comparative Medicine Research Farm, University of Missouri, Columbia, Missouri, 65201, USA

    A. Y. Sun & G. Y. Sun

  14. Terre Haute Center for Medical Education, Indiana University School of Medicine, Terre Haute, Indiana, 47809, USA

    Walter X. Balcavage, Douglas Bell & Vincent J. Cristofalo

  15. The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania, 19104, USA

    Vincent J. Cristofalo, Gary L. Grove & Nancy E. Olashaw

  16. Department of Physics, Indiana State University, Terre Haute, Indiana, USA

    Torsten Alväger

  17. Department of Chemistry, Indiana State University, Terre Haute, Indiana, USA

    Walter X. Balcavage

  18. Terre Haute Center for Medical Education and Department of Biochemistry, Indiana University School of Medicine, USA

    Walter X. Balcavage

  19. Department of Dermatology, The University of Pennsylvania, Philadelphia, Pennsylvania, 19174, USA

    James J. Leyden, Kenneth J. McGinley, Gary L. Grove & Albert M. Kligman

  20. The Upjohn Company, Kalamazoo, Michagan, 49001, USA

    Phillip I. Good

  21. Memorial Sloan-Kettering Cancer Center, New York, N.Y., 10021, USA

    N. I. Swislocki, J. Tierney, J. Zinberg & S. R. Pfeffer

  22. Laboratories of Molecular Biology and Genetics, The University of Wisconsin, Madison, Wisconsin, 53706, USA

    K. D. Munkres & R. S. Rana

Authors
  1. Ralph L. Cooper
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  2. Steven Brandt
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  3. Markku Linnoila
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  4. Louise H. Greenberg
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  5. Robert K. Dix
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  6. Benjamin Weiss
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  7. K. Reichlmeier
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  8. A. Enz
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  9. P. Iwangoff
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  10. W. Meier-Ruge
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  11. L. R. Weiss
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  12. S. Krop
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  13. Bryon N. de Sousa
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  14. Z. V. Kendrick
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  15. Jay Roberts
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  16. Steven I. Baskin
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  17. Thomas L. Klug
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  18. Richard C. Adelman
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  19. C. Lee Robinette
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  20. Michael G. Mawhinney
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  21. Cynthia J. Moore
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  22. Arthur G. Schwartz
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  23. R. N. Sorrentino
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  24. J. R. Florini
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  25. D. D. Schocken
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  26. G. S. Roth
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  27. P. J. Gill
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  28. D. M. Hanson
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  29. A. Y. Sun
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  30. G. Y. Sun
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  31. Walter X. Balcavage
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  32. Douglas Bell
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  33. Vincent J. Cristofalo
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  34. Torsten Alväger
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  35. James J. Leyden
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  36. Kenneth J. McGinley
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  37. Gary L. Grove
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  38. Albert M. Kligman
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  39. Phillip I. Good
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  40. N. I. Swislocki
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  41. J. Tierney
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  42. J. Zinberg
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  43. S. R. Pfeffer
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  44. K. D. Munkres
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  45. R. S. Rana
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  46. Edward M. Cohen
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  47. Paula B. Goldberg
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  48. Sallie-Ann Stoner
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  49. Nancy E. Olashaw
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Editor information

Editors and Affiliations

  1. Medical College of Pennsylvania and Philadelphia Geriatric Center, USA

    Jay Roberts

  2. Temple University Institute on Aging and Fels Research Institute and Philadelphia Geriatric Center, USA

    Richard C. Adelman

  3. The Wistar Institute and Philadelphia Geriatric Center, USA

    Vincent J. Cristofalo

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© 1978 Springer Science+Business Media New York

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Cooper, R.L. et al. (1978). Reinstatement of Ovarian Cycles in Aged Female Rats by Placement of L-Dopa in the Medial Preoptic Area. In: Roberts, J., Adelman, R.C., Cristofalo, V.J. (eds) Pharmacological Intervention in the Aging Process. Advances in Experimental Medicine and Biology, vol 97. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7793-1_15

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  • DOI: https://doi.org/10.1007/978-1-4684-7793-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7795-5

  • Online ISBN: 978-1-4684-7793-1

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