Analysis of the Interrelationships of Non-Nutrient Blood Flow, Oxygen Delivery, Oxygen Consumption, and the Ratio of Oxygen Delivery/Oxygen Consumption Based on a Mathematical Model of Non-Nutrient Blood Flow

  • Kevin Farrell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


Non-nutrient blood flow (NNBF) is defined for the purposes of this model as any blood flow that does not participate in oxygen exchange at the level of the microcirculation. It theoretically includes intra-cardiac and large vessel left to right shunts, anatomic and physiologic shunting in the microcirculation, decreased cellular utilization of oxygen, and decreased diffusion of oxygen.


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  1. 1.
    Shoemaker, W. C., Launder, W. J., Castagna, J. Method for estimating the perfusion defect in shock. J. Surg. Research 20, 77, 1976.CrossRefGoogle Scholar
  2. 2.
    Farrell, K., Linberg, S. and Witte, C. Further efforts to quantify non-nutrient blood flow. Critical Care Medicine 7, 237, 1981.Google Scholar
  3. 3.
    Farrell, K., Linberg, S. and Witte, C. Determination of total body non-nutrient blood flow. 8, 252, 1980.Google Scholar
  4. 4.
    Data from D. Wilmore in The Metabolic Management of the Critically Ill, Plenum Medical Book Company, New York, 1977.Google Scholar
  5. 5.
    Bryan-Brown, C. W. in section on ‘Gas Transport and Delivery’ Page I(E):8 in Critical Care — State of the Art Volume I published by the Society of Critical Care Medicine, 1980.Google Scholar
  6. 6.
    Shoemaker, W. C. Page 77 in The Organ in Shock published as a ‘Scope’ monograph in 1976 by the Upjohn Company, Kalamazoo, Michigan.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Kevin Farrell
    • 1
  1. 1.Departments of Surgery and AnesthesiologyWest Virginia University School of MedicineMorgantownUSA

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