Abstract
Chlorpromazine hydrochloride (CPZ) a widely used tranquilizer was earlier shown to preferentially sensitize hypoxic bacterial cells to 60Co gamma rays (Shenoy, George, Singh & Ayengar, 1975). CPZ was also observed to be toxic towards hypoxic cells (Shenoy & Singh, 1978) and this hypoxic cytotoxicity was found to be dependent on temperature. When tested in murine tumors, the drug sensitized Sarcoma 180A (Shenoy & Singh, 1980) as well as fibrosarcoma (George Srinivasan & Singh, 1980) to x-rays. A marked chemotherapeutic effect of CPZ was evident in Sarcoma 180A (Shenoy & Singh, 1980) and this effect was more pronounced in clamped tumors (George et al., 1980), indicating the effectiveness of the drug when cells were under acute hypoxia.
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© 1983 Plenum Press, New York
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Shenoy, M.A., Biaglow, J.E., Varnes, M.E., Hetzel, F.W. (1983). Inhibition of Cultured Human Tumor Cell Oxygen Utilization by Chlorpromazine. In: Bicher, H.I., Bruley, D.F. (eds) Oxygen Transport to Tissue—IV. Advances in Experimental Medicine and Biology, vol 159. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7790-0_31
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DOI: https://doi.org/10.1007/978-1-4684-7790-0_31
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