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Inhibition of Cultured Human Tumor Cell Oxygen Utilization by Chlorpromazine

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Oxygen Transport to Tissue—IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 159))

Abstract

Chlorpromazine hydrochloride (CPZ) a widely used tranquilizer was earlier shown to preferentially sensitize hypoxic bacterial cells to 60Co gamma rays (Shenoy, George, Singh & Ayengar, 1975). CPZ was also observed to be toxic towards hypoxic cells (Shenoy & Singh, 1978) and this hypoxic cytotoxicity was found to be dependent on temperature. When tested in murine tumors, the drug sensitized Sarcoma 180A (Shenoy & Singh, 1980) as well as fibrosarcoma (George Srinivasan & Singh, 1980) to x-rays. A marked chemotherapeutic effect of CPZ was evident in Sarcoma 180A (Shenoy & Singh, 1980) and this effect was more pronounced in clamped tumors (George et al., 1980), indicating the effectiveness of the drug when cells were under acute hypoxia.

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Author information

Authors and Affiliations

  1. Division of Radiation Biology — Radiobiological Sciences & Hyperthermia Division, Henry Ford Hospital, Detroit, Michigan, 48202, USA

    M. A. Shenoy, J. E. Biaglow, M. E. Varnes & F. W. Hetzel

  2. Case Western Reserve University, Cleveland, Ohio, 44106, USA

    M. A. Shenoy, J. E. Biaglow, M. E. Varnes & F. W. Hetzel

Authors
  1. M. A. Shenoy
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  2. J. E. Biaglow
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  3. M. E. Varnes
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  4. F. W. Hetzel
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Editor information

Editors and Affiliations

  1. Hyperthermia Group, Western Tumor Medical Group, Van Nuys, California, USA

    Haim I. Bicher (President ISOTT) (President ISOTT)

  2. Louisiana Tech University, Ruston, Louisiana, USA

    Duane F. Bruley (President-Elect ISOTT) (President-Elect ISOTT)

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© 1983 Plenum Press, New York

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Shenoy, M.A., Biaglow, J.E., Varnes, M.E., Hetzel, F.W. (1983). Inhibition of Cultured Human Tumor Cell Oxygen Utilization by Chlorpromazine. In: Bicher, H.I., Bruley, D.F. (eds) Oxygen Transport to Tissue—IV. Advances in Experimental Medicine and Biology, vol 159. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7790-0_31

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  • DOI: https://doi.org/10.1007/978-1-4684-7790-0_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7792-4

  • Online ISBN: 978-1-4684-7790-0

  • eBook Packages: Springer Book Archive

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