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Delayed Recovery Following Hypothermic Arrest in Rabbit Myocardium

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Oxygen Transport to Tissue—IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 159))

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Abstract

The purpose of this investigation was to determine the relationship between the duration of myocardial ischemia at 15°C and the time required for the myocardium to recover maximum contractile function following the ischemia. The isolated blood perfused rabbit heart was used as a model of myocardial ischemia.

Hearts frau 22 New Zealand white rabbits were divided into four groups. In Group I seven hearts were subjected to 15 minutes of ischemia at 15°C. In Group II five hearts were subjected to 30 minutes of ischemia at 15°C. In Groups III and IV the ischemia time was extended to 60 and 120 minutes, respectively. Following the ischemia each heart was reperfused at normothermia and papillary muscle contractility was measured and used as an index of myocardial recovery.

Hearts in Group I recovered their maximum contractile function after an average of 22.5 minutes. Those in Groups II, III, and IV were fully recovered after 31.7, 38.2, and 45.5 minutes, respectively. The study indicates that the time required for the maximum recovery of myocardial contractility following myocardial ischemia increases at a decreasing rate with an increase in the duration of the ischemia at 15°C.

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Author information

Authors and Affiliations

  1. St. Luke’s Hospital Medical Center, Phoenix, Arizona, USA

    R. Leighton Fisk, Eric J. Guilbeau, Steven J. Edgar, Anita J. Switzer & Lisa K. Moore

  2. Department of Chemical and Bioengineering, Arizona State University, Tempe, Arizona, USA

    R. Leighton Fisk, Eric J. Guilbeau, Steven J. Edgar, Anita J. Switzer & Lisa K. Moore

Authors
  1. R. Leighton Fisk
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  2. Eric J. Guilbeau
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  3. Steven J. Edgar
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  4. Anita J. Switzer
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  5. Lisa K. Moore
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Editor information

Editors and Affiliations

  1. Hyperthermia Group, Western Tumor Medical Group, Van Nuys, California, USA

    Haim I. Bicher (President ISOTT) (President ISOTT)

  2. Louisiana Tech University, Ruston, Louisiana, USA

    Duane F. Bruley (President-Elect ISOTT) (President-Elect ISOTT)

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© 1983 Plenum Press, New York

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Fisk, R.L., Guilbeau, E.J., Edgar, S.J., Switzer, A.J., Moore, L.K. (1983). Delayed Recovery Following Hypothermic Arrest in Rabbit Myocardium. In: Bicher, H.I., Bruley, D.F. (eds) Oxygen Transport to Tissue—IV. Advances in Experimental Medicine and Biology, vol 159. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7790-0_19

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  • DOI: https://doi.org/10.1007/978-1-4684-7790-0_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7792-4

  • Online ISBN: 978-1-4684-7790-0

  • eBook Packages: Springer Book Archive

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