Vascular Wall PO2 Following Carbon Monoxide Exposure

  • Donald G. Buerk
  • Thomas K. Goldstick
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


Cigarette smoking and atherosclerosis may be linked to vascular wall damage caused by carbon monoxide (CO), nocotine or exposure to other toxic substances. Vascular wall hypoxia may play an important role in this process. Schneiderman and Goldstick (1,2) have simulated the effect of CO exposure on O2 transport to the wall of the human thoracic aorta using a computer model. The wall of the thoracic aorta and other large blood vessels must depend on O2 supply from both the vessel lumen and from the microvasculature of the outer wall (vasa vasorum). A two layer tissue model was chosen to represent the vascular wall in their analysis, with the tissue properties (O2consumption rate, Q, diffusivity, D, and solubility, K) for each layer estimated from the literature. The location and value of the minimum PO2 (Pmin) in the wall will depend on these tissue properties, as well as the wall dimensions and boundary conditions at the inner endothelial and outer adventitial edges of the a vascular portion of the wall. The computer studies indicate that Pmin will decrease with increasing levels of carboxyhemoglobin (COHb) within the range experienced by heavy smokers (up to 20%). Their model predicts that the middle or inner medial layer is most susceptible to hypoxic damage.


Thoracic Aorta Vascular Wall Outer Wall Vessel Lumen Hypoxic Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Schneiderman, G. and Goldstick, T. K., Computer simulation of the human thoracic aorta to evaluate the possible role of smoking in atherogenesis, Adv. in Exp. Med. and Biol.94:407–412, 1978.CrossRefGoogle Scholar
  2. 2.
    Schneiderman, G. and Goldstick, T. K., Carbon monoxide-induced arterial wall hypoxia and atherosclerosis, Atherosclerosis 30: 1–15, 1978.PubMedCrossRefGoogle Scholar
  3. 3.
    Buerk, D. G., Hypoxia in the walls of large blood vessies, Ph.D. Thesis, Northwestern University, Department of Chemical Engineering, Evanston, II., 1980.Google Scholar
  4. 4.
    Buerk, D. G., Goldstick, T. K., Ernest, J. T. and Dobrin, P. B., Oxygen tension profiles and oxygen consumption inhomogeneities in the arterial wall: Implications for atherogenesis, Adv. in Physiol. Sci. 25: 23–24, 1981.Google Scholar
  5. 5.
    Roughton, F. J. W. and Darling, R. C., The effect of carbon monoxide on the oxyhemoglobin dissociation curve, Am. J. Physiol 141: 17–31, 1944.Google Scholar
  6. 6.
    Collier, C. R., Oxygen affinity of human blood in presence of carbon monoxide, J. Appl. Physiol 40: 487–490, 1976.PubMedGoogle Scholar
  7. 7.
    Ledwith, J. W., Determining P50 in the presence of carboxyhemoglobin, J. Appl. Physiol 44: 317–321, 1978.PubMedGoogle Scholar
  8. 8.
    Severinghaus, J. W., Blood gas calculator, J. Appl. Physiol 21: 1108–1116, 1966.Google Scholar
  9. 9.
    Paul, R. J., Bauer, M. and Pease, W., Vascular smooth muscle: aerobic glycolysis linked to sodium and potassium transport, Science 206: 1414–1416, 1979.PubMedCrossRefGoogle Scholar
  10. 10.
    Whalen, W. J. and Spande, J. I., A hypodermic needle 1002 electrode, J. Appl. Physiol 48: 186–187, 1980.PubMedGoogle Scholar
  11. 11.
    Kanabus, E. W., Feldstein, C. and Crawford, D. W., Excursion of vibrating microelectrodes in tissue, J. Appl. Physiol 48: 737–741, 1980.PubMedGoogle Scholar
  12. 12.
    Sylvester, J. T. et al, Hypoxic and CO hypoxia in dogs: henodynamics, carotid reflexes and catecholamines, Am. J. Physiol.236: H22–28,.979.Google Scholar
  13. 13.
    Spohr, U. et ai, Evaluation of smoling-induced effects on sympathetic, hemodynamic and metabolic variables with respect to plasma nicotine and COHb levels, Atherosclerosis 33: 271–283, 1979.PubMedCrossRefGoogle Scholar
  14. 14.
    Doyle, J. M. and Dobrin, P. B., Stress gradients in the walls of large arteries, J. Biomech 16: 631–639, 1973.CrossRefGoogle Scholar
  15. 15.
    Marcus, M. L., Heistad, D. D., Armstrong, M. L. and Abboud, F. M., Effects of chronic hypertension on vasa vasorum in the thoracic aorta, Circulation 56: 201, 1977. (abstract)CrossRefGoogle Scholar
  16. 16.
    Buerk, D. G. and Goldstick, T. K., An evaluation of the importance of the vasa vasorum for oxygenation of vascular wall tissue in vivo, Microvas, Res. 21: 238, 1981.Google Scholar
  17. 17.
    Heistad, D. D., Marcus, M. L., Larsen, G. E. and Armstrong, M. L., Role of vasa vasorum in nourishment of the aortic wall, Am. J. Physiol 240: H781–787, 1981.PubMedGoogle Scholar
  18. 18.
    Heistad, D. D., Armstrong, M. L., and Marcus, M. L., Hyperemia of the aortic wall in atherosclerotic monkeys, Circ. Res 48: 669–675, 1981.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Donald G. Buerk
    • 1
  • Thomas K. Goldstick
    • 1
  1. 1.Department of Chemical EngineeringNorthwestern UniversityEvanstonUSA

Personalised recommendations