Correlation of Brain NADH Redox State, K+, PO2 and Electrical Activity During Hypoxia, Ischemia and Spreading Depression
The normal functioning brain requires a continuous supply of blood in order to obtain glucose as well as oxygen. Any change in the oxygenation of the tissue will result in an impairment of the normal function. Most of the oxygen taken up by the brain is consumed by the mitochondria in order to supply the large amount of ATP needed. A major part of the ATP is used by the ATPase system in order to keep the neurons in the polarized state. Figure 1 shows in a schematic way the interrelation between the energy production system and the pumping activity going on in the membranes. In order to understand the connection between various events occurring in the brain in vivo, one has to measure as many parameters as possible from the same site.
KeywordsLight Guide Spreading Depression Cellulose Diacetate Gerbil Brain Bilateral Carotid Occlusion
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- 4.Mayevsky, A., Crowe, W. and Mela, L., The interrelation between brain oxidative metabolism and extracellular potassium in the unanesthetized gerbil. Neurolog. Res. 1, 213–226, 1980.Google Scholar
- 6.Lehmenkuhler, A., Speckmann, E. J. and Garpers, H., Cortical spreading depression in relation to potassium activity, oxygen tension, local flow and carbon dioxide tension. In Ion and Enzyme Electrodes in Biology and Medicine. (Kessler, M., Clark, L. C., Lubbers, D. W., Silver, I. A. and Simon, W., eds.), Munich: Urban and Schwarzenberg, pp. 311–315, 1976.Google Scholar
- 7.Leniger-Follert, E., Urbanics, R., Harbig, K. and Lubbers, D. W., The behavior of local pH and NADH-fluorescence during and after direct activation of the brain cortes. In Cerebral Function, Metabolism and Circulation (Ingvar, O. H., Lassen, N. A., eds) pp. 214–225, Munksgaard, Copenhagen, 1977.Google Scholar
- 9.LeMana, J. C., Cordingley, G. and Rosenthal, M., Phenobarbital actions in vivo: effects on extracellular potassium activity and oxidative metabolism in cat cerebral cortex. J. Pharmacol. Exp. Ther., 200, 560–569, 1977.Google Scholar