Correlation of Brain NADH Redox State, K+, PO2 and Electrical Activity During Hypoxia, Ischemia and Spreading Depression

  • A. Mayevsky
  • D. L. Sclarksy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 159)


The normal functioning brain requires a continuous supply of blood in order to obtain glucose as well as oxygen. Any change in the oxygenation of the tissue will result in an impairment of the normal function. Most of the oxygen taken up by the brain is consumed by the mitochondria in order to supply the large amount of ATP needed. A major part of the ATP is used by the ATPase system in order to keep the neurons in the polarized state. Figure 1 shows in a schematic way the interrelation between the energy production system and the pumping activity going on in the membranes. In order to understand the connection between various events occurring in the brain in vivo, one has to measure as many parameters as possible from the same site.


Light Guide Spreading Depression Cellulose Diacetate Gerbil Brain Bilateral Carotid Occlusion 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • A. Mayevsky
    • 1
  • D. L. Sclarksy
    • 1
  1. 1.Johnson Research Foundation and Cerebrovascular Research Center, Department of NeurologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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