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Progression and Regression of Atherosclerotic Lesions

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The Thrombotic Process in Atherogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 104))

Abstract

The most important concepts in understanding the progression and regression of clinically significant coronary atherosclerosis and the ways in which this disease process produces its most common clinical effects have been changing rapidly.

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References

  1. Getz, G.S., Vesselinovitch, D., and Wissler, R.W. (1969) Amer. J. Med. 46, 657–673.

    Google Scholar 

  2. Wissler, R.W. (1974) in The Myocardium: Failure and Infarction, (Braunwald, E., Ed.), H.P. Publishing Co., New York, pp. 155–166.

    Google Scholar 

  3. Wissler, R.W. (1974) in Comparative Pathology of the Heart (Adv. Cardiol., vol. 13) (Homberger, F., Ed.), S. Karger, Basel, pp. 10–13.

    Google Scholar 

  4. Wissler, R.W., Vesselinovitch, D., and Getz, G.S. (1976) Prog. Cardiovas. Dis. 18, 341–369.

    CAS  Google Scholar 

  5. Wissler, R.W., and Vesselinovitch, D. (1974) in Atherosclerosis III (Proc. 3rd Intl. Symp.) (Schettler, G. and Weizel, A., Springer-Verlag, Berlin/Heidelberg/New York, pp. 747–750.

    Google Scholar 

  6. Wissler, R.W., and Vesselinovitch, D. (1975) in Verh. deuts. Ges. inn. Med., J.F. Bergmann, Munich, pp. 857–865.

    Google Scholar 

  7. Wissler, R.W., and Vesselinovitch, D. (1976) Ann. N.Y. Acad. Sci. 275, 363–378.

    PubMed  CAS  Google Scholar 

  8. Wissler, R.W. (1977) in Brain and Heart Infarct, (Zulch, K.J., Ed.), Springer-Verlag, Berlin/Heidelberg/New York, pp. 206–255.

    Google Scholar 

  9. Smith, E.B. (1977) Am. J. Pathol. 86, 665–674.

    PubMed  CAS  Google Scholar 

  10. Haust, M.D., More, R.H., and Movat, H.Z. (1960) Am. J. Pathol. 37, 377–389.

    PubMed  CAS  Google Scholar 

  11. Geer, J.C., McGill, H.C., Jr., and Strong, J.P. (1961) Am. J. Pathol. 38, 263–287.

    PubMed  CAS  Google Scholar 

  12. McGill, H.C., and Geer, J.C. (1963) in Evolution of the Atherosclerotic Plaque (Jones, R.J., Ed.), University of Chicago Press, Chicago, pp. 65–76.

    Google Scholar 

  13. Geer, J.C., and Haust, M.D. (1972) Smooth Muscle Cells in Atherosclerosis, Vol. 2, S. Karger, Basel.

    Google Scholar 

  14. Kao, V.C.Y., and Wissler, R.W. (1965) Exp. Mol. Pathol. 4, 465–479.

    PubMed  CAS  Google Scholar 

  15. Knieriem, H.J., Kao, V.C.Y., and Wissler, R.W. (1967) Arch. Pathol. 84, 118–129.

    PubMed  CAS  Google Scholar 

  16. Wissler, R.W. (1968) J. Atheroscl. Res. 8, 201–213.

    Google Scholar 

  17. Ross, R., and Klebanoff, S.J. (1971) J. Cell Biol. 50, 159–171.

    PubMed  CAS  Google Scholar 

  18. Ross, R. (1971) J. Cell Biol. 50, 172–186.

    PubMed  CAS  Google Scholar 

  19. Fischer-Dzoga, K., Jones, R.M., Vesselinovitch, D., and Wissler, R.W. (1973) Exp. Mol. Pathol. 18, 162–176.

    Google Scholar 

  20. Chen, R., Dzoga, K., Borensztajn, J., and Wissler, R.W. (1972) Circulation 46 (Suppl. II ), 253.

    Google Scholar 

  21. Chen, R. (1973) Ph.D. Thesis, University of Chicago.

    Google Scholar 

  22. Fischer-Dzoga, K., Chen, R., and Wissler, R.W. (1974) in Arterial Mesenchyme and Arteriosclerosis (Wagner, W.D. and Clarkson, T.B., Eds.), Plenum Press, New York, pp. 299–311.

    Google Scholar 

  23. Bates, S.R. (1976) Fed. Proc. 35, 7a.

    Google Scholar 

  24. Chen, R.M., Getz, G.S., Fischer-Dzoga, K., and Wissler, R.W. (1974) Fed. Proc. 33, 623a.

    Google Scholar 

  25. Chen, R.M., Getz, G.S., Fischer-Dzoga, K., and Wissler, R.W. (1977) Exp. Mol. Pathol. 26, 359–374.

    PubMed  CAS  Google Scholar 

  26. Chen, R.M., Fischer-Dzoga, K., and Wissler, R.W. (1977) in Atherosclerosis IV (Proc. 4th Intl. Symp.), (Schettler, G., Klose, G., Hata, Y. and Goto, Y., Eds.), Springer-Verlag, Berlin/Heidelberg/New York. In press.

    Google Scholar 

  27. Chen, R.M., and Fischer-Dzoga, K. (1977) Atherosclerosis. In press.

    Google Scholar 

  28. Hanig, M., Shainoff, J.R., and Lowry, A.D. (1956) Science 124, 176–178.

    PubMed  CAS  Google Scholar 

  29. Gero, S., Gergely, J., Jakab, L., Szekely, J., and Virag, S. (1961) J. Atheroscl. Res. 1, 88–91.

    CAS  Google Scholar 

  30. Tracy, R.E., Merchant, E.B., and Kao, V. (1961) Circ. Res. 9, 472–478.

    PubMed  CAS  Google Scholar 

  31. Watts, H.F. (1963) in Evolution of the Atherosclerotic Plaque (Jones, R.J., Ed.), University of Chicago Press, Chicago, pp. 117–132.

    Google Scholar 

  32. Walton, K.W., and Williamson, N. (1968) J. Atheroscl. Res. 8, 599–624.

    CAS  Google Scholar 

  33. Hoff, H.F., Lie, J.T., Titus, J.L., Bayardo, R.J., Jackson, R., L., DeBakey, M.E., and Gotto, A.M., Jr. (1975) Arch. Pathol. 99, 253–258.

    PubMed  CAS  Google Scholar 

  34. Smith, E.B., Slater, R.S., and Crothers, D.C. (1974) in Atherosclerosis III (Proc. 3rd Intl. Symp.), (Schettler, G. and Weizel, A., Eds.), Springer-Verlag, Berlin/Heidelberg/New York, pp. 96–99.

    Google Scholar 

  35. Hollander, W., Kramsch, D.M., and Inoune, G. (1968) in Progress in Biochemical Pharmacology, vol. 4 (Miras, C.J., Howard, A.N. and Paoletti, R., Eds.), S. Karger, Basel, pp. 270–279.

    Google Scholar 

  36. Scott, P.J., and Hurley, P.J. (1970) Atherosclerosis 11, 77103.

    Google Scholar 

  37. Brown, M.S., and Goldstein, J.L. (1974) Proc. Nat. Acad. Sci. USA 71, 788–790.

    Google Scholar 

  38. Brown, M.S., and Goldstein, J.L. (1976) Science 191, 150–154.

    PubMed  CAS  Google Scholar 

  39. Goldstein, J.L., and Brown, M.S. (1977) Ann. Rev. Biochem. 46, 897–930.

    PubMed  CAS  Google Scholar 

  40. Weinstein, D.B., Carew, T.E., and Steinberg, D. (1976) Biochim. Biophys. Acta 424, 404–421.

    PubMed  CAS  Google Scholar 

  41. Iverius, P.H. (1972) J. Biol. Chem. 247, 2607–2613.

    PubMed  CAS  Google Scholar 

  42. Berenson, G.S., Srinivasan, S.R., Radhakrishnamurthy, B., and Dalferes, E.R., Jr. (1974) in Arterial Mesenchyme and Arteriosclerosis (Wagner, W.D. and Clarkson, T.B., Eds.), Plenum Press, New York, pp. 141–159.

    Google Scholar 

  43. Tracy, R.E., Dzoga, K., and Wissler, R.W. (1965) Proc. Soc. Exp. Biol. Med. 118, 1095–1098.

    PubMed  CAS  Google Scholar 

  44. Constantinides, P. (1965) Experimental Atherosclerosis, Elsevier, Amsterdam.

    Google Scholar 

  45. Bondjers, G., and Bjorkerud, S. (1972) Atherosclerosis 15, 273–284.

    PubMed  CAS  Google Scholar 

  46. Minick, C.R., and Murphy, G.E. (1973) Am. J. Pathol. 73, 265–300.

    PubMed  CAS  Google Scholar 

  47. Astrup, P., Kjeldsen, K., and Wanstrup, J. (1967) J. Atheroscl. Res. 7, 343–354.

    Google Scholar 

  48. Ross, R., and Harker, L.B. (1977) N. Engl. J. Med. In press.

    Google Scholar 

  49. Kao, V.C.Y., Wissler, R.W., and Dzoga, K. (1968) Circulation 38, (Suppl. IV ) 12.

    Google Scholar 

  50. Dzoga, K., Vesselinovitch, D., Fraser, R., and Wissler, R.W. (1971) Am. J. Pathol. 62, 32a.

    Google Scholar 

  51. Fischer-Dzoga, K., Jones, R.M., Vesselinovitch, D., and Wissler, R.W. (1974) in Atherosclerosis III (Proc. 3rd Intl. Symp.), (Schettler, G. and Weizel, A., Eds.), Springer-Verlag, Berlin/ Heidelberg/New York, pp. 193–195.

    Google Scholar 

  52. Fischer-Dzoga, K., Wissler, R.W., and Scanu, A.M. (1974) Circulation 50 (Suppl. III ), 263.

    Google Scholar 

  53. Fischer-Dzoga, K., and Wissler, R.W. (1976) Atherosclerosis 24, 515–525.

    PubMed  CAS  Google Scholar 

  54. Fischer-Dzoga, K., Fraser, R., and Wissler, R.W. (1976) Exp. Mol. Pathol. 24, 346–359.

    PubMed  CAS  Google Scholar 

  55. Fischer-Dzoga, K., Wissler, R.W., and Scanu, A.M. (1977) in Atherosclerosis: Metabolic, Morphologic and Clinical Aspects (Adv. Exp. Biol. Med., vol. 82), (Manning, G.W. and Haust, M.D., Eds.), Plenum Press, New York, pp. 915–920.

    Google Scholar 

  56. Robertson, A.L. (1974) Am. J. Pathol. 74, 94a.

    Google Scholar 

  57. Robertson, A.L. (1974) in Atherosclerosis III (Proc. 3rd Intl. Symp.), (Schettler, G. and Weizel, A., Eds.), Springer-Verlag, Berlin/Heidelberg/New York, pp. 175–184.

    Google Scholar 

  58. Fischer-Dzoga, K., Vesselinovitch, D., and Wissler, R.W. (1974) Am. J. Pathol. 74, 52a.

    Google Scholar 

  59. Yoshida, Y., Fischer-Dzoga, K., and Wissler, R.W. (1977) Circulation. In press.

    Google Scholar 

  60. Gospodarowicz, D., and Moran, J.S. (1975) J. Cell Biol. 66, 451–457.

    PubMed  CAS  Google Scholar 

  61. Antoniades, H.N., Strathkos, D., and Scher, C.D. (1975) Proc. Nat. Acad. Sci. USA 72, 2635–2639.

    PubMed  CAS  Google Scholar 

  62. Ross, R., Glomset, J., Kariya, B., and Harker, L.B. (1974) Proc. Nat. Acad. Sci. USA 71, 1027–1210.

    Google Scholar 

  63. Van Wyk, J.J., and Underwood, L.E. (1975) Ann. Rev. Med. 26, 427–441.

    PubMed  Google Scholar 

  64. Ledet, T., Fischer-Dzoga, K., and Wissler, R.W. (1976) Diabetes 25, 207–215.

    PubMed  CAS  Google Scholar 

  65. Fischer-Dzoga, K., Pick, R., and Kuo, Y-F. (1977) Circulation. In press.

    Google Scholar 

  66. Wissler, R.W. (1977) in Biochemistry of Atherosclerosis (Scanu, A.M., Ed.), Marcel Dekker, New York. In press.

    Google Scholar 

  67. Fishman, J.A., Ryan, G.B., and Karnovsky, M.J. (1975) Lab. Invest. 32, 339–351.

    PubMed  CAS  Google Scholar 

  68. Bjorkerud, S., and Bondjers, G. (1971) Atherosclerosis 14, 259–276.

    PubMed  CAS  Google Scholar 

  69. Bjorkerud, S., and Bondjers, G. (1973) Atherosclerosis 18, 235–255.

    PubMed  CAS  Google Scholar 

  70. Glagov, S., and Ts’ao, C.H. (1975) Am. J. Pathol. 79, 7–30.

    PubMed  CAS  Google Scholar 

  71. Ross, R., and Harker, L. (1976) Science 193, 1094–1100.

    PubMed  CAS  Google Scholar 

  72. Ross, R., and Glomset, J. (1973) Science 180, 1332–1339.

    PubMed  CAS  Google Scholar 

  73. Ross, R., and Glomset, J. (1974) in Arterial Mesenchyme and Arteriosclerosis (Wagner, W.D. and Clarkson, T.B., Eds.), Plenum Press, New York, pp. 265–279.

    Google Scholar 

  74. Harker, L., Slichter, S.J., Scott, C.R., and Ross, R. (1974) N. Engl. J. Med. 291, 537–543.

    PubMed  CAS  Google Scholar 

  75. Harker, L.A., Ross, R., Slichter, S.J., and Scott, C.R. (1976) J. Clin. Invest. 58, 731–741.

    PubMed  CAS  Google Scholar 

  76. Moore, S., Friedman, R.J., Singal, D.P., Gauldie, J., and Blajchman, M. (1976) Thromb. Diathes. Haemorrh. 35, 70–81.

    CAS  Google Scholar 

  77. Benditt, E.P.., and Benditt, J.M. (1973) Proc. Nat. Acad. Sci. USA 70, 1753–1756.

    Google Scholar 

  78. Pearson, T.A., Wang, A., Solez, K., and Heptinstall, R.H. (1975) Am. J. Pathol. 81, 379–388.

    PubMed  CAS  Google Scholar 

  79. Thomas, W.A., Janakidevi, K., Reiner, J.M., and Lee, K.T. (1976) Circulation 54 (Suppl. II ), 137.

    Google Scholar 

  80. Rothblat, G.H. (1973) in Growth, Nutrition and Metabolism of Cells in Culture, vol. 1, (Rothblat, G.H. and Cristofalo, V., Eds.), Academic Press, New York, pp. 297–325.

    Google Scholar 

  81. St. Clair, R.W., Lofland, H.B., Jr., Prichard, R.W., and Clarkson, T.B. (1968) Exp. Mol. Pathol. 8, 201–215.

    Google Scholar 

  82. Bates, S.R., and Wissler, R.W. (1976) Biochim. Biophys. Acta 450, 78–88.

    PubMed  CAS  Google Scholar 

  83. Peters, T.J., Takano, T., and DeDuve, C. (1973) in Atherogenesis: Initiating Factors (Ciba Found. Symp. 12), Elsevier, Amsterdam, pp. 197–214.

    Google Scholar 

  84. Goldfischer, S., Daly, M.M., Kasak, L.E., and Coltoff-Schiller, B. (1975) Circ. Res. 36, 553–561.

    PubMed  Google Scholar 

  85. Smith, E.B., and Slater, R.J. (1973) in Atherogenesis: Initiating Factors (Ciba Found. Symp. 12), Elsevier, Amsterdam, pp. 39–52.

    Google Scholar 

  86. Wissler, R.W., and Vesselinovitch, D. (1968) Ann. N.Y. Acad. Sci. 149, 907–922.

    PubMed  CAS  Google Scholar 

  87. Wissler, R.W., and Vesselinovitch, D. (1974) in Atherosclerosis III (Proc. 3rd Intl. Symp.), (Schettler, G. and Weizel, A., Eds.), Springer-Verlag, Berlin/Heidelberg/New York, pp. 319–325.

    Google Scholar 

  88. Vesslinovitch, D., and Wissler, R.W. (1977) in Atherosclerosis: Metabolic, Morphologic and Clinical Aspects (Adv.. Exp. Biol. Med., vol. 82), (Manning, G.W. and Haust, M.D., Eds.), Plenum Press, New York, pp. 614–622.

    Google Scholar 

  89. Strong, J.P., Ed. (1976) Atherosclerosis in Primates (Prim. in Med., vol. 9 ), S. Karger, Basel.

    Google Scholar 

  90. Gresham, G.A. (1976) Primate Atherosclerosis, S. Karger, Basel.

    Google Scholar 

  91. Wissler, R.W., and Vesselinovitch, D. (1977) Advances in Veterinary Science and Comparative Medicine, Vol. 21, (Simpson, C. F., Ed. ), pp. 351–420.

    Google Scholar 

  92. Florentin, R.A., and Nam, S.C. (1968) Exp. Mol. Pathol. 8, 263–301.

    PubMed  CAS  Google Scholar 

  93. Thomas, W.A., Florentin, R.A., Nam, S.C., Kim, D.N., Jones, R. M., and Lee, K.T. (1968) Arch. Pathol. 86, 621–643.

    PubMed  CAS  Google Scholar 

  94. Prichard, R.W., Clarkson, T.B., Goodman, H.O., and Lofland, H. B. (1966) Arch. Pathol. 81, 292–301.

    PubMed  CAS  Google Scholar 

  95. Taylor, C.B., Patton, D.E., and Cox, G.E. (1963) A.M.A. Arch. Pathol. 76, 404–412.

    CAS  Google Scholar 

  96. Taylor, C.B., Manalo-Estrella, P., and Cox, G.E. (1963) A.M.A. Arch. Pathol. 76, 239–249.

    CAS  Google Scholar 

  97. Kramsch, D.M., and Hollander, W. (1968) Exp. Mol. Pathol. 9, 1–22.

    PubMed  CAS  Google Scholar 

  98. Vesselinovitch, D., Getz, G.S., Hughes, R.H., and Wissler, R.W. (1974) Atherosclerosis 20, 303–321.

    PubMed  CAS  Google Scholar 

  99. Wissler, R.W., Vesselinovitch, D., Borensztajn, J., Schaffner, T., and Hughes, R. (1976) Fed. Proc. 35, 294.

    Google Scholar 

  100. Wissler, R.W., and Vesselinovitch, D. (1977) in Atherosclerosis IV (Proc. 4th Intl. Symp.), (Schettler, G., Klose, G., Hata, Y. and Goto, Y., Eds.), Springer-Verlag, Berlin/Heidelberg/New York. In press.

    Google Scholar 

  101. Armstrong, M.L. (1976) Atherosclerosis Reviews 1, 137–182.

    CAS  Google Scholar 

  102. Wissler, R.W. (1977) in Proceedings of the First Joint Meeting of the German, Swiss and Austrian Societies for Angiology, Springer-Verlag, Berlin/Heidelberg/New York. In press.

    Google Scholar 

  103. Armstrong, M.L., Warner, E.D., and Connor, W.E. (1970) Circ. Res. 27, 59–67.

    PubMed  CAS  Google Scholar 

  104. Armstrong, M.L., and Megan, M.B. (1972) Circ. Res. 30, 675–680.

    PubMed  CAS  Google Scholar 

  105. Armstrong, M.L., and Megan, M.B. (1975) Circ. Res. 36, 256–261.

    PubMed  CAS  Google Scholar 

  106. Armstrong, M.L. (1977) in Atherosclerosis IV (Proc. 4th Intl. Symp.), (Schettler, G., Klose, G., Hata, Y. and Goto, Y., Eds.), Springer-Verlag, Berlin/Heidelberg/New York. In press.

    Google Scholar 

  107. Vesselinovitch, D., Wissler, R.W., Hughes, R., and Borensztajn, J. (1976) Atherosclerosis 23, 155–176.

    Google Scholar 

  108. Wissler, R.W., Vesselinovitch, D., Borensztajn, J., and Hughes, R. (1975) Circulation 52 (Suppl. II ), 16.

    Google Scholar 

  109. Borensztajn, J., Foreman, K., Wissler, R.W., van Zutphen, H., Vesselinovitch, D., and Hughes, R. (1975) Circulation 52 (Suppl. II ), 269.

    Google Scholar 

  110. Borensztajn, J. Personal communication.

    Google Scholar 

  111. Weber, G., Fabbrini, P., Resi, L., Jones, R., Vesselinovitch, D., and Wissler, R.W. (1977) Atherosclerosis 26, 535–547.

    PubMed  CAS  Google Scholar 

  112. Daoud, A.S., Jarmolych, J., Augustyn, J.M., Fritz, K.E., Singh, K.E., and Lee, K.T. (1976) Arch. Pathol. Lab. Med. 100, 37 2379.

    Google Scholar 

  113. Fritz, K.E., Augustyn, J.M., Jarmolych, J., Daoud, A.S., and Lee, K.T. (1976) Arch. Pathol. Lab. Med. 100, 380–385.

    PubMed  CAS  Google Scholar 

  114. Blankenhorn, D.H., Brooks, S.H., Selzer, R.H., Crawford, D.W., and Chin, H.P. (1974) Proc. Soc. Exp. Biol. Med. 145, 1298 1300.

    Google Scholar 

  115. Crawford, D.W., Beckenback, E.S., Blankenhorn, D.H., Selzer, R.H., and Brooks, S.H. (1974) Atherosclerosis 19, 231–241.

    PubMed  CAS  Google Scholar 

  116. Barndt, R., Jr., Blankenhorn, D.H., Crawford, D.W., and Brooks, S.H. (1977) Ann. Int. Med. 86, 139–146.

    PubMed  Google Scholar 

  117. Blankenhorn, D. (1977) in Atherosclerosis: Metabolic, Morphologic and Clinical Aspects (Adv. Exp. Biol. Med., vol. 82), (Manning, G.W. and Haust, M.D., Eds.), Plenum Press, New York, pp. 453–458.

    Google Scholar 

  118. Buchwald, H., Moore, R.B., and Varco, R.L. (1975) in Lipids, Lipoproteins and Drugs (Adv. Exp. Biol. Med., vol. 63), (Kritchevsky, D., Paoletti, R. and Holmes, W.L., Eds.), Plenum Press, New York, pp. 221–230.

    Google Scholar 

  119. Buchwald, H., Amplatz, K., and Varco, R.L. (1977) in Proceedings of the International Symposium State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models, Springer-Verlag, Berlin/Heidelberg/New York. In press.

    Google Scholar 

  120. Chen, R.M. (1975) Presented in a paper which won the Young Investigator’s Award of the American College of Cardiology.

    Google Scholar 

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Wissler, R.W. (1978). Progression and Regression of Atherosclerotic Lesions. In: Chandler, A.B., Eurenius, K., McMillan, G.C., Nelson, C.B., Schwartz, C.J., Wessler, S. (eds) The Thrombotic Process in Atherogenesis. Advances in Experimental Medicine and Biology, vol 104. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7787-0_5

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