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Assay of Fibrinopeptides A and B and of Released Platelet Proteins as a Measure of Activation of Hemostasis

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The Thrombotic Process in Atherogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 104))

Abstract

Our understanding of relationships between atherosclerosis and the hemostatic system would be greatly enhanced, if tests were available which would reproducibly and clearly demonstrate perturbations of the system in association with atherosclerosis. Tests of the hemostatic mechanism may be divided into two general types, those which measure the functional status of different components and those which measure the products of specific reactions. Functional status tests have been particularly useful in distinguishing, diagnosing and monitoring therapy in the bleeding disorders but have been of very limited usefulness in studying thromboembolism. The results of studies with functional tests in which patients with atherosclerosis were compared with patients with other disease are not available. The newly developed tests which measure the products of hemostatic reactions appear to be useful in studying thromboembolism and await application to the study of atherosclerosis. The present manuscript will review the theoretical basis for these tests and summarize the limited available clinical data. The results of studies on patients with hyperlipidemia will also be discussed.

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Author information

Authors and Affiliations

  1. College of Physicians and Surgeons, Columbia University, New York, New York, USA

    Hymie L. Nossel

Authors
  1. Hymie L. Nossel
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Editor information

Editors and Affiliations

  1. Department of Pathology, Medical College of Georgia, USA

    A. Bleakley Chandler

  2. National Heart, Lung, and Blood Institute, National Institutes of Health, USA

    Karl Eurenius  & Gardner C. McMillan  & 

  3. Division of Scientific Affairs, American Heart Association, USA

    Curtis B. Nelson

  4. Department of Pathology, University of Texas, San Antonio, USA

    Colin J. Schwartz

  5. Department of Medicine, New York University School of Medicine, USA

    Stanford Wessler

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© 1978 Plenum Press, New York

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Nossel, H.L. (1978). Assay of Fibrinopeptides A and B and of Released Platelet Proteins as a Measure of Activation of Hemostasis. In: Chandler, A.B., Eurenius, K., McMillan, G.C., Nelson, C.B., Schwartz, C.J., Wessler, S. (eds) The Thrombotic Process in Atherogenesis. Advances in Experimental Medicine and Biology, vol 104. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7787-0_34

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  • DOI: https://doi.org/10.1007/978-1-4684-7787-0_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7789-4

  • Online ISBN: 978-1-4684-7787-0

  • eBook Packages: Springer Book Archive

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