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Possible Effects of Risk Factors on Fibrinolysis

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Book cover The Thrombotic Process in Atherogenesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 104))

Abstract

The hypothesis that atheromatous plaques originate as intimai collections of blood components was first advanced by Rokitansky (1). This hypothesis has since been revived by Duguid (2) and others (3, 4). Recent findings in support of this concept include the demonstration that the intimai deposits may consist of platelets as well as fibrin. The presence of high thromboplastic activity in the intimai layer of blood vessels, especially arteries (5), provides a mechanism for fibrin or platelet deposition. Additionally, any increase in the coagulability of the circulating blood would facilitate the process. On the other hand, fibrinolytic activity is high in the vascular intima, though less active in arteries than in veins, and could be important in the removal of mural thrombi.

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Author information

Authors and Affiliations

  1. Northwestern University Medical School and Veterans Administration Lakeside Hospital, Chicago, Illinois, USA

    Hau C. Kwaan

Authors
  1. Hau C. Kwaan
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Editor information

Editors and Affiliations

  1. Department of Pathology, Medical College of Georgia, USA

    A. Bleakley Chandler

  2. National Heart, Lung, and Blood Institute, National Institutes of Health, USA

    Karl Eurenius  & Gardner C. McMillan  & 

  3. Division of Scientific Affairs, American Heart Association, USA

    Curtis B. Nelson

  4. Department of Pathology, University of Texas, San Antonio, USA

    Colin J. Schwartz

  5. Department of Medicine, New York University School of Medicine, USA

    Stanford Wessler

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© 1978 Plenum Press, New York

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Kwaan, H.C. (1978). Possible Effects of Risk Factors on Fibrinolysis. In: Chandler, A.B., Eurenius, K., McMillan, G.C., Nelson, C.B., Schwartz, C.J., Wessler, S. (eds) The Thrombotic Process in Atherogenesis. Advances in Experimental Medicine and Biology, vol 104. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7787-0_17

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  • DOI: https://doi.org/10.1007/978-1-4684-7787-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7789-4

  • Online ISBN: 978-1-4684-7787-0

  • eBook Packages: Springer Book Archive

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