Abstract
Atherogenesis is characterized in part by excessive proliferation of arterial intimal smooth muscle cells (SMC). Arterial SMC proliferation can be produced by acute or chronic intimal trauma in normo-lipidemic (NL) animals, especially if the endothelial cells (EC) are denuded as with a balloon catheter. Also, intimal SMC proliferation can be produced by making animals hyperlipidemic (HL) by dietary manipulation without trauma to the EC.
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Thomas, W.A., Mustard, J.F., Moore, S., Karnovsky, M.J., Bersot, T.P., Wolinsky, H. (1978). Summary of Workshop 1b: Smooth Muscle. In: Chandler, A.B., Eurenius, K., McMillan, G.C., Nelson, C.B., Schwartz, C.J., Wessler, S. (eds) The Thrombotic Process in Atherogenesis. Advances in Experimental Medicine and Biology, vol 104. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7787-0_13
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DOI: https://doi.org/10.1007/978-1-4684-7787-0_13
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