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Homeostasis of Phosphate and Other Minerals pp 217–223Cite as

Further Evidence Supporting the Phosphate Leak Hypothesis of Idiopathic Hypercalciuria

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 103))

Abstract

We have previously reported (1,2) that a group of patients with idiopathic hypercalciuria (IH) exhibited certain metabolic characteristics. Compared with age- and sex-matched control subjects, the IH patients were normocalcemic, but their serum phosphate and immunoreactive parathyroid hormone (PTH) concentrations were lower, serum 1,25-dihydroxyvitamin D (1,25-diOHD) concentration, urinary calcium excretion, and fractional enteral calcium absorption were higher. Even though their serum phosphate concentration was lower than that of the controls, urinary phosphate excretion was normal in the IH patients due to a lower TTP/GFR (2).

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References

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Author information

Authors and Affiliations

  1. Seattle VA Hospital, Seattle, WA, 98108, USA

    F. H. Shen, J. L. Ivey, D. J. Sherrard, R. L. Nielsen, M. R. Haussler & D. J. Baylink

  2. American Lake VA Hospital, Tacoma, WA, 98493, USA

    F. H. Shen, J. L. Ivey, D. J. Sherrard, R. L. Nielsen, M. R. Haussler & D. J. Baylink

  3. Department of Medicine, University of Washington, Seattle, WA, 98195, USA

    F. H. Shen, J. L. Ivey, D. J. Sherrard, R. L. Nielsen, M. R. Haussler & D. J. Baylink

  4. The Mason Clinic, Seattle, WA, 98111, USA

    F. H. Shen, J. L. Ivey, D. J. Sherrard, R. L. Nielsen, M. R. Haussler & D. J. Baylink

  5. Department of Biochemistry, College of Medicine, University of Arizona, Tucson, AZ, 85724, USA

    F. H. Shen, J. L. Ivey, D. J. Sherrard, R. L. Nielsen, M. R. Haussler & D. J. Baylink

Authors
  1. F. H. Shen
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  2. J. L. Ivey
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  3. D. J. Sherrard
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  4. R. L. Nielsen
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  5. M. R. Haussler
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  6. D. J. Baylink
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry (M.D.) (M.D.)

  2. University of Heidelberg, Heidelberg, Germany

    Eberhard Ritz (M.D.) (M.D.)

  3. Fundación Jiménez Díaz, Madrid, Spain

    Aurelio Rapado (M.D.) (M.D.)

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© 1978 Plenum Press, New York

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Shen, F.H., Ivey, J.L., Sherrard, D.J., Nielsen, R.L., Haussler, M.R., Baylink, D.J. (1978). Further Evidence Supporting the Phosphate Leak Hypothesis of Idiopathic Hypercalciuria. In: Massry, S.G., Ritz, E., Rapado, A. (eds) Homeostasis of Phosphate and Other Minerals. Advances in Experimental Medicine and Biology, vol 103. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7758-0_23

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  • DOI: https://doi.org/10.1007/978-1-4684-7758-0_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7760-3

  • Online ISBN: 978-1-4684-7758-0

  • eBook Packages: Springer Book Archive

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