Skip to main content
SpringerLink
Log in

Recent Progress in Renal Handling of Phosphate

  • Chapter
Homeostasis of Phosphate and Other Minerals

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 103))

  • 125 Accesses

Abstract

In mammals inorganic phosphate (Pi) is filtered at the glomerulus and reabsorbed in the tubules (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. MUDGE, G.H., BERNDT, W.O., and VALTIN, H.: Tubular transport of urea, glucose, phosphate, uric acid, sulfate, and thiosulfate. In: Handbook of Physiology, Orloff, J. and Berliner, R. W. (eds). American Physiological Society, Washington, pp. 587–652, 1973.

    Google Scholar 

  2. HARRIS, C.A., BAER, P.G., CHIRITO, E., and DIRKS, J.H.: Composition of mammalian glomerular filtrate. Am. J. Physiol. 227: 972, 1974.

    PubMed  CAS  Google Scholar 

  3. LE GRIMELLEC, C., POUJEOL, P., and de ROUFFIGNAC, C.: 3H-inulin and electrolyte concentration in Bowman’s capsule in rat kidney. Pflügers Arch. 354: 117, 1975.

    Article  PubMed  CAS  Google Scholar 

  4. STRICKLER, J.C., THOMPSON, D.D., KLOSE, R.M., and GIEBISCH, G.: Micropuncture study of inorganic phosphate excretion in the rat. J. clin. Invest. 43: 1596, 1964.

    Article  PubMed  CAS  Google Scholar 

  5. KUNTZIGER, H., AMIEL, C., and GAUDEBOUT, C.: Phosphate handling by the rat nephron during saline diuresis. Kidney Intern. 2: 318, 1972.

    Article  CAS  Google Scholar 

  6. DENNIS, V.W., WOODHALL, P.B., and ROBINSON, R.R.: Characteristics of phosphate transport in isolated proximal tubule. Am. J. Physiol. 231: 979, 1976.

    PubMed  CAS  Google Scholar 

  7. ROCHA, A.S., MAGALDI, J.B., and KOKKO, J.P.: Calcium and phosphate transport in isolated segments of rabbit Henle’s loop. J. clin. Invest. 59: 975, 1977.

    Article  PubMed  CAS  Google Scholar 

  8. AMIEL, C., KUNTZIGER, H., and RICHET, G.: Micropuncture study of handling of phosphate by proximal and distal nephron in normal and parathyroidectomized rat. Evidence for distal reabsorption. Pflügers Arch. 317: 93, 1970.

    Article  PubMed  CAS  Google Scholar 

  9. KNOX, F.G., GREGER, R.F., LANG, F.C., and MARCHAND, G.R.: Renal handling of phosphate: Update. 2nd International Workshop on Phosphate, Heidelberg 1976, Plenum Press, page 3, 1977.

    Google Scholar 

  10. LEGRIMELLEC, C., ROINEL, N., and MOREL, F.: Simultaneous Mg, C., P, K, Na and Cl analysis in rat tubules fluid. I-During perfusion of either inulin or ferrocyanide. Pflügers Arch. 340: 181, 1973.

    Article  CAS  Google Scholar 

  11. GOLDBERG, M.: Renal handling of phosphate: an overview. 1st International Workshop, Phosphate Metabolism, Kidney and Bone, Paris, 1975.

    Google Scholar 

  12. STAUM, B.B., HAMBURGER, R.J., and GOLDBERG, M.: Tracer micro-injection study of renal tubular phosphate reabsorption in the rat. J. clin. Invest. 51: 2271, 1972.

    Article  PubMed  CAS  Google Scholar 

  13. BRUNETTE, M.G., TAÏEB, L., and CARRIERE, S.: Effect of parathyroid hormone on phosphate reabsorption along the nephron of the rat. Am. J. Physiol. 225: 1076, 1973.

    PubMed  CAS  Google Scholar 

  14. GREGER, R., LANG, F., MARCHAND, G.R., and KNOX, F.G.: Nephron site of phosphate reabsorption in thyroparathyroidectomized rat. Fed. Proc. 35: 466, 1976.

    Google Scholar 

  15. LANG, F., GREGER, R., MARCHAND, G.R., and KNOX, F.G.: Stationary microperfusion study of phosphate reabsorption in proximal and distal nephron segments. Pflügers Arch. 368: 45, 1977.

    Article  PubMed  CAS  Google Scholar 

  16. POUJEOL, P., and de ROUFFIGNAC, C.: Microinjection studies of phosphate permeability in rats during mild saline diuresis: influence of acute thyroparathyroidectomy and parathormone administration. 1st International Workshop, Phosphate Metabolism, Kidney and Bone, Paris 1975.

    Google Scholar 

  17. POUJEOL, P., CORMAN, B., TOUVAY, C., and de ROUFFIGNAC, C.: Renal reabsorption of phosphate (P) by the rat nephron. Intra-renal heterogeneity and strain differences. XXVIIth International Congress of Physiological Sciences, Paris, 1977.

    Google Scholar 

  18. POUJEOL, P., CHABARDES, D., ROINEL, N., and de ROUFFIGNAC, C.: Influence of extracellular fluid volume expansion on magnesium, calcium and phosphate handling along the rat nephron. Pflügers Arch. 365: 203, 1976.

    Article  PubMed  CAS  Google Scholar 

  19. CHABARDES, D., IMBERT, M., CLIQUE, A., MONTEGUT, M., and MOREL, F.: PTH sensitive Adenyl cyclase activity in different segments of the rabbit nephron. Pflügers Arch. 354: 229, 1975.

    Article  PubMed  CAS  Google Scholar 

  20. MOREL, F., CHABARDES, D., and IMBERT, M.: Functional segmentation of the rabbit distal tubule by microdetermination of hormone-dependent adenylate cyclase activity. Kidney Intern. 9: 264, 1976.

    Article  CAS  Google Scholar 

  21. BOUDRY, J.F., TROEHLER, V., TOUABI, M., FLEISCH, H., and BONJOUR, J.P.: Secretion of inorganic phosphate in the rat nephron. Clin. Sci. mol. Med. 48: 475, 1975.

    CAS  Google Scholar 

  22. SHIRLEY, D.G., POUJEOL, P., and LE GRIMELLEC, C.: Phosphate, calcium and magnesium fluxes into the lumen of the rat proximal convoluted tubule. Pflügers Arch. 362: 247, 1976.

    Article  PubMed  CAS  Google Scholar 

  23. SCHNEIDER, E.G., and Mc LANE, L.A.: Evidence for a peritubular-to-luminal flux of phosphate in the dog kidney. Am. J. Physiol. 232: F 159, 1977.

    Google Scholar 

  24. MURAYAMA, Y., MOREL, F., and LE GRIMELLEC, C.: Phosphate, calcium and magnesium transfers in proximal tubules and loops of Henle, as measured by single nephron microperfusion experiments in the rat. Pflügers Arch. 333: 1, 1972.

    Article  PubMed  CAS  Google Scholar 

  25. GREGER, R.F., LANG, F.C., KNOX, F.G., and LECHENE, C.P.: Absence of significant secretory flux of phosphate in the proximal convoluted tubule. Am. J. Physiol. 232: F 235, 1977.

    Google Scholar 

  26. EICHER, E.M., SOUTHARD, J.L., SCRIVER, C.R., and GLORIEUX, F.H.: Hypophosphatemia: Mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets. Proc. natl. Acad. Sci. USA 73: 4667, 1976.

    Article  PubMed  CAS  Google Scholar 

  27. BRUNETTE, M.G., GIASSON-DESJARDINS, S., VIGNEAULT, N., and CARRIERE, S.: Micropuncture study of phosphorus transport in genetic hypophosphatemic mice. 3rd International Workshop on phosphate and other minerals, Madrid 1977.

    Google Scholar 

  28. GLORIEUX, F., and SCRIVER, C.R.: Loss of a parathyroid hormone sensitive component of phosphate transport in X-linked hypophosphatemia. Science 175: 997, 1972.

    Article  PubMed  CAS  Google Scholar 

  29. ULLRICH, K.J.: Mechanisms of cellular and subcellular transport of phosphate. 3rd International Workshop on phosphate and other minerals, Madrid, 1977.

    Google Scholar 

  30. HOFFMANN, N., TREES, M., and KINNE, R.: Phosphate transport by isolated brush border vesicles. Pflügers Arch. 362: 147, 1976

    Article  PubMed  CAS  Google Scholar 

  31. AGUS, Z.S., PUSCHETT, J.B., SENESKY, D., and GOLDBERG, M.: Mode of action of parathyroid hormone and cyclic adenosine 3’,5’-monophosphate on renal tubular phosphate reabsorption in the dog. J. clin. Invest. 50: 617, 1971.

    Article  PubMed  CAS  Google Scholar 

  32. GEKLE, D.: Der Einfluss von Parathormon auf die Nierenfunktion. Pflügers Arch. 323: 96, 1971.

    Article  PubMed  CAS  Google Scholar 

  33. KUNTZIGER, H., AMIEL, C., ROINEL, N., and MOREL, F.: Effects of parathyroidectomy and cyclic AMP on renal transport of phosphate, calcium, and magnesium. Am. J. Physiol. 227: 905, 1974.

    PubMed  CAS  Google Scholar 

  34. CHASE, L.R., and AURBACH, G.D.: Parathyroid function and the renal excretion of 3’,5’-adenylic acid. Proc. Natl. Acad. Sci. USA 58: 518, 1967.

    Article  PubMed  CAS  Google Scholar 

  35. SHLATZ, L.J., SCHWARTZ, I.L., KINNE-SAFFRAN, E., and KINNE, R.: Distribution of parathyroid hormone-stimulated adenylate cyclase in plasma membranes of cells of the kidney cortex. J. Membrane Biol. 24: 131, 1975.

    Article  CAS  Google Scholar 

  36. KINNE, R., SHLATZ, L.J., KINNE-SAFFRAN, E., and SCHWARTZ, I.L.: Distribution of membrane - bound cyclic AMP - dependent protein kinase in plasma membranes of cells of the kidney cortex. J. Membrane Biol. 24: 145, 1975.

    Article  CAS  Google Scholar 

  37. FILBURN, C.R. and SACKTOR, B.: Cyclic nucleotide phosphodiesterases of rabbit renal cortex. Characterization of brush border membrane activities. Arch. Biochem. Biophys. 174: 249, 1976.

    Article  PubMed  CAS  Google Scholar 

  38. BUTLEN, D., and JARD, S.: Renal handling of 3’,5’-cyclic AMP in the rat: the possible role of luminal 3’,5’-cyclic AMP in the tubular reabsorption of phosphate. Pflügers Arch. 331: 172, 1972.

    Article  PubMed  CAS  Google Scholar 

  39. KUNTZIGER, H., CAILLA, H.L., AMIEL, C., and DELAAGE, M.A.: Renal tubular handling of 3’,5’-cAMP in normal and parathyroidectomized rats. 2nd International Workshop on Phosphate, Heidelberg 1976, Plenum Press, page 75, 1977.

    Google Scholar 

  40. ARDAILLOU, R., ISAAC, R., NIVEZ, M.P., KUHN, J.M., CAZOR, J.L., and FILLASTRE, J.P.: Effect of salmon calcitonin on renal excretion of adenosine 3’,5’-monophosphate in man. Horm. Metab. Res. 8: 136, 1976.

    Article  PubMed  CAS  Google Scholar 

  41. RASMUSSEN, H., PECHET, M., and FAST, D.: Effect of dibutyryl. cyclic adenosine 3’,5’-monophosphate, theophylline, and other nucleotides upon calcium and phosphate metabolism. J. clin. Invest. 47: 1843, 1968.

    Article  PubMed  CAS  Google Scholar 

  42. ROBINSON, G.A., BUTCHER, and SUTHERLAND, E.W.: in Cyclic AMP, Chapter 5, page 91, Academic Press, New York, 1971.

    Google Scholar 

  43. COULSON, R.: Metabolism and excretion of exogenous adenosine 3’,5’-monophosphate and guanosine 3’,5’-monophosphate. Studies in the isolated perfused rat kidney and in the intact rat. J. biol. Chem. 251: 4958, 1976.

    PubMed  CAS  Google Scholar 

  44. GORIN, E., and BRENNER, T.: Extracellular metabolism of cyclic AMP. Biochim. Biophys. Acta 451: 20, 1976.

    Article  PubMed  CAS  Google Scholar 

  45. INSEL, P., BALAKIR, R., and SACKTOR, B.: The binding of cyclic AMP to renal brush border membranes. J. Cyclic Nucleotide Research 1: 107, 1975.

    CAS  Google Scholar 

  46. WALKENBACH, R.J., and FORTE, C.R.: Solubilization and photo-affinity labeling of renal membrane cyclic AMP receptors. Biochim. Biophys. Acta 464: 165, 1977.

    Article  PubMed  CAS  Google Scholar 

  47. BAUMANN, K., CHAN, Y.L., BODE, F., and PAPAVASSILIOU, F.: Effect of parathyroid hormone and cyclic adenosine 3’,5’monophosphate on isotonic fluid reabsorption: Polarity of proximal tubular cells. Kidney Intern. 11: 77, 1977.

    Article  CAS  Google Scholar 

  48. STEELE, T.H., ENGLE, J.E., TANAKA, Y., LORENC, R.S., DUDGEON, K.L., and DE LUCA, H.F.: Phosphatemic action of 1,25 - dihydroxy-vitamin D3. Am. J. Physiol. 229: 489, 1975.

    PubMed  CAS  Google Scholar 

  49. TROHLER, U., BONJOUR, J.P., and FLEISCH, H.: Inorganic phosphate homeostasis: Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. J. clin. Invest. 57: 264, 1976.

    Article  PubMed  CAS  Google Scholar 

  50. STEELE, T.H., and DE LUCA, H.F.: Influence of the dietary phosphorus on renal phosphate reabsorption in the parathyroidectomized rat. J. clin. Invest. 57: 867, 1976.

    Article  PubMed  CAS  Google Scholar 

  51. BONJOUR, J.P., TROHLER U., MÜHLBAUER, R., PRESTON, C., and FLEISCH,H.: Is there a bone-kidney link in the homeostasis of inorganic phosphate (Pi) ? 2nd International Workshop on Phosphate, Heidelberg 1976, Plenum Press, page 319, 1977.

    Google Scholar 

  52. GORBMAN, A.: Endocrinology of the amphibia. In: Physiology of the Amphibia, Moore, J.A. (ed.) Academic Press, pp. 391–393, 1964.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM U.64, Hôpital Tenon, Paris, France

    Henri Kuntziger & Claude Amiel

  2. Lab. Physiologie, Hôpital Louis Mourier, Colombes, France

    Henri Kuntziger & Claude Amiel

Authors
  1. Henri Kuntziger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claude Amiel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry (M.D.) (M.D.)

  2. University of Heidelberg, Heidelberg, Germany

    Eberhard Ritz (M.D.) (M.D.)

  3. Fundación Jiménez Díaz, Madrid, Spain

    Aurelio Rapado (M.D.) (M.D.)

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Plenum Press, New York

About this chapter

Cite this chapter

Kuntziger, H., Amiel, C. (1978). Recent Progress in Renal Handling of Phosphate. In: Massry, S.G., Ritz, E., Rapado, A. (eds) Homeostasis of Phosphate and Other Minerals. Advances in Experimental Medicine and Biology, vol 103. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7758-0_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7758-0_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7760-3

  • Online ISBN: 978-1-4684-7758-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation