Controlled Release of Biologically Active Agents

  • Seymour Yolles
Part of the Polymer Science and Technology book series (POLS, volume 8)


The development of injectable systems for sustained delivery of drugs at a controlled rate has been the object of various publications. In 1946, a patent [1] was issued claiming pellets consisting of dispersions of a desiccated hormone in waxy media as a new system for a slow and prolonged release of active materials. Substitution of the waxy media as matrices by silicones for fertility control was reported by other investigators [2, 3, 4, 5]. A recent innovation is the use of biodegradable polymers such as polylactic acid (PLA), which will also assure a complete delivery of the drug [6].


Release Rate Polylactic Acid Control Release Delivery Rate Cumulative Amount 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Saunder, F. J. and Raymond, A. L., U. S. Patent 2, 413, 419 (1946).Google Scholar
  2. 2.
    Doyle, L. L. and Clewe, T. H., Amer. J. Obstet. Gynecol., 101, 564 (1968).Google Scholar
  3. 3.
    Mishell, D. R., Jr. and Lumkin, M. E., Fertil. Steril., 21, 99 (1970).Google Scholar
  4. 4.
    Roseman, T. J. and Higuchi, W. I., J. Pharm. Sci., 59, 353 (1970).CrossRefGoogle Scholar
  5. 5.
    Roseman, T. J., ibid., 61, 46 (1972).CrossRefGoogle Scholar
  6. 6.
    Woodland, J.H.R., Yolles, S., Blake, D. A., Helrich, M., and Meyer, F. J., J. Med. Chem., 16, 897 (1973).CrossRefGoogle Scholar
  7. 7.
    Lazarus, J., Pagliery, M., and Lachman, L., J. Pharm. Sci., 53, 798 (1964).CrossRefGoogle Scholar
  8. 8.
    Farhadieh, B., Borodkin, S., and Buddenhagen, J. D., ibid., 60, 209 (1971).CrossRefGoogle Scholar
  9. 9.
    Higuchi, T., ibid., 52, 1145 (1963).CrossRefGoogle Scholar
  10. 10.
    Yolles, S., Eldridge, J. E., and Woodland, J.H.R., Polym. News, 1, 9 (1971).Google Scholar
  11. 11.
    Archer, S., in Narcotic Antagonists, M. C. Braude, et al., Eds., Adv. Biochem. Psychopharmacol., 8, 549 (1974).Google Scholar
  12. 12.
    Newsweek, January 4, 1971.Google Scholar
  13. 13.
    Martin, W. R. and Sandquist, V. L., presented at the 34th Annual Meeting on Problems of Drug Dependence, Ann Arbor, Michigan, May 22–24, 1972.Google Scholar
  14. 14.
    Yolles, S., Leafe, T. D., Woodland, J.H.R., and Meyer, F. J., J. Pharm. Sci., (in press).Google Scholar
  15. 15.
    Yolles, S., Leafe, T.D., and Meyer, F. J., ibid., (in press).Google Scholar
  16. 16.
    Wall Street Journal, December 7, 1970.Google Scholar
  17. 17.
    Chem. Eng. News, February 19, 1973, p. 33.Google Scholar
  18. 18.
    Tanquary, A. C., Cowsar, D. R., and Lacey, R. E., Bull. So. Res. Inst., 25, 2 (1972).Google Scholar
  19. 19.
    Leafe, T. D., Sarner, S., Woodland, J.H.R., Yolles, S., Blake, D. A., and Meyer, F. J., in Narcotic Antagonists, M. C. Braude, et al., Eds., Adv. Biochem. Psychopharmacol., 8, 569 (1974).Google Scholar
  20. 20.
    McCarthy, A., personal communication.Google Scholar
  21. 21.
    Reuning, R. H., personal communication.Google Scholar
  22. 22.
    Martin, W. R. and Sandquist, V. L., Arch. Gen. Psychiatry, 30, 31 (1974).CrossRefGoogle Scholar
  23. 23.
    The Merck Index, 8th ed, Merck and Co., Inc., Rahway, New Jersey, 1968.Google Scholar
  24. 24.
    Cleare, M. J. and Hoeschele, J. D., Bioinorg. Chem., 2, 187 (1973).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Seymour Yolles
    • 1
  1. 1.Department of ChemistryUniversity of DelawareNewarkUSA

Personalised recommendations