Ultrastructure and Biochemical Studies of Rat CNS and Viscera after Subcutaneous Injection of Chlorphentermine

  • Masazumi Adachi
  • Chhin-Yang Tsai
  • Mark Greenbaum
  • Barbara Mask
  • Bruno W. Volk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 68)


Chlorphentermine, known as an anoretic drug, has been reported by Franken and associates to induce the formation of foamy cells in the lungs of rats (1). Subsequently, several investigators have described cytoplasmic inclusion bodies in the viscera (2–9) which are considered to be the experimental counterpart of human lipidosis.


Inclusion Body Thin Layer Chromatogram Neuraminic Acid Neuronal Cytoplasm Total Sialic Acid 
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Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Masazumi Adachi
    • 1
  • Chhin-Yang Tsai
    • 1
  • Mark Greenbaum
    • 1
  • Barbara Mask
    • 1
  • Bruno W. Volk
    • 1
  1. 1.Isaac Albert Research Institute of the Kingsbrook Jewish Medical CenterBrooklynUSA

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