Studies in Metachromatic Leukodystrophy. XIII. Purification of Sulfatase A from Normal Human Liver
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Metachromatic leukodystrophy (MLD) is a genetically-determined neurolipidosis characterized by deficient activity of sulfatase A (cerebroside sulfatase) and by the resultant accumulation of cerebroside sulfate. Immunological studies using a monospecific antibody to sulfatase A have shown that MLD patients do have the enzyme protein (7). The reason why this protein has little or no activity is not yet clear. The first step in such a study is to isolate and characterize the normal sulfatase.
KeywordsAryl Sulfatase Metachromatic Leukodystrophy Normal Human Liver Purify Enzyme Preparation Aryl Sulfatase Acti
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