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Molecular Basis of Interferon Action

  • Chapter
Cell Regulation by Intracellular Signals

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 44))

Abstract

Interferon was discovered 24 years ago by Isaacs and Lindenmann (1957). Allantoic fluid from chick embryonated egg previously inoculated with inactivated influenza virus contained an antiviral activity detectable when transferred to fresh cells. This potent activity was pH 2 resistant, inactivated by trypsin, and not sedimentable at 100,000 x g. This substance was rapidly found to have important other properties: it had a broad spectrum of antiviral activity i.e. it was active against most animal viruses; it was species specific and was relatively non toxic. All these fundamental properties have been amended recently (section 7 and 10) although the basic observations remain essentially true. Extension of these early observations to other animal systems have led to considerable development of interferon research in several directions. It is widely recognized now that the antiviral activity of interferon (IFN), which led to its discovery, is only the “visible part of an iceberg”, since IFN has a large spectrum of other activities (Stewart II, 1979b; De Clercq, 1980): it can exert an anticellular activity, or antitumour activity

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  1. Institut Pasteur du Brabant, 28, rue du Remorquer, B-1040, Brussels, Belgium

    Jean Content & Martine Verhaegen-Lewalle

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  1. Jean Content
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  1. University of Brussels Medical School, Brussels, Belgium

    Stéphane Swillens  & Jacques E. Dumont  & 

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Content, J., Verhaegen-Lewalle, M. (1982). Molecular Basis of Interferon Action. In: Swillens, S., Dumont, J.E. (eds) Cell Regulation by Intracellular Signals. NATO Advanced Study Institutes Series, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7718-4_23

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  • DOI: https://doi.org/10.1007/978-1-4684-7718-4_23

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