Abstract
Cells possess within the plasma membrane a variety of proteins involved in the reception, transduction and amplification of extra-cellular signals. Neurotransmitters and many hormones serve as intercellular signal molecules that alter target cell function upon interaction with cell surface, structure-specific receptors. Beta adrenergic receptors (BAR) can be included in this class of plasma membrane proteins that mediate transmembrane processes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson, W.B. and Kaworski, C.J., 1979, Isoproterenol-induced Desensitization of Adenylate Cyclase Responsiveness in a Cell-free System, J. Bio. Chem, 254: 4596.
Barber, R., Clark, R.B., Kelly, L.A., and Butcher, R.W., 1978, A Model of Desensitization ii} Intact Cells, Adv. Cyclic Nucleotide, 9: 507.
Bockaert, J., Hunzicker-Dunn, M., and Birnbaumer, L., 1976, Hormone-stimulated Desensitization of Hormone-dependent Adenylyl Cyclase, J. Bio. Chem, 251: 2653.
Caron, M.G., Srinivasan, Y., Pitha, J., Kociolek, K., and Lefkowitz, R.J., 1979, Affinity Chromatography of the ß-Adrenergic Receptor, J. Bio. Chem., 254: 2923.
Cassel, D. and Selinger, Z., 1977, Mechanism of Adenylate Cyclase Activation by Cholera Toxin: Inhibition of GTP Hydrolysis at the Regulatory Site, Proc. Natl. Acad. Sci. U.S.A, 74: 3307.
Chuang, D.M. and Costa, E., 1979, Evidence for Internalization of the Recognition Site of ß-Adrenergic Receptors During Receptor Sub-sensitivity Induced by (-)Isoproterenol, Proc. Natl. Acad. Sci. U.S.A, 76: 3024.
Citri, Y. and Schramm, M., 1980, Resolution, Reconstitution and Kinetics of the Primary Action of a Hormone Receptor, Nature, 287: 297.
Ezra, E. and Salomon, Y., 1980, Mechanism of Desensitization of Adenylate Cyclase by Lutropin, J. Bio. Chem, 255: 653.
Gill, D.M. and Meren, R., 1978, ADP-ribosylation of Membrane Proteins Catalyzed by Cholera Toxin: Basis of the Activation of Adenylate Cyclase, Proc. Natl. Acad. Sci. U.S.A, 75: 3050.
Haga, T., Haga, K., and Gilman, A.G., 1977, Hydrodynamic Properties of the ß-Adrenergic Receptor and Adenylate Cyclase From Wild Type and Variant S49 Lymphoma Cells, J. Bio. Chem, 252: 5776.
Harden, T.K., Cotton, C.U., Waldo, G.L., Lutton, J.K., and Perkins, J.P., 1980, Catecholamine-induced Alteration in the Sedimentation Behaviour of Membrane-bound ß-adrenergic Receptors, Science, 210: 441.
Harden, Y.K., Su, Y.F., and Perkins, J.P., 1979, Catecholamine-induced Desensitization Involves an Uncoupling of ß-adrenergic Receptors and Adenylate Cyclase, J. Cyclic Nucleotide Res, 5: 99.
Howlett, A.C., Sternweis, P.C., Macik, B.A., Van Arsdale, P.M., and Gilman, A.G., 1979, Reconstitution of Catecholamine-sensitive Adenylate Cyclase, J. Bio. Chem, 254: 2287.
Iyengar, R., Bhat, M., Riser, M., and Birnbaumer, L., 1981, Receptor Specific Desensitization of the S49 Lymphoma Cell Adenylyl Cyclase Unaltered Behaviour of the Regulatory Component. J. Bio. Chem, 256.
Kalisker, A., Rutledge, C.O., and Perkins, J.P., 1973, Effect of Nerve Degeneration by 6-hydroxydopamine on Catecholamine-stimulated Adenosine 3’, 5’-monophosphate Formation in Rat Cerebral Cortex, Mol. Pharmacol, 9: 619.
Kent, R.S., DeLean, A., and Lefkowitz, R.J., 1980, A Quantitative Analysis of ß-adrenergic Receptor Interactions: Resolution of High and Low Affinity States of the Receptor by Computer Modeling of Ligand Binding Data, Mol. Pharmacol, 17: 14.
Lefkowitz, R.J., Wessels, M.R., and Stadel, J.M., 1980, Hormones, Receptors, and Cyclic AMP: Their Role in Target Cell Refractoriness, Current Topics in Cell Reg, 17: 205.
Lefkowitz, R.J. and Williams, L.T., 1978, Molecular Mechanisms of Activation and Desensitization of Adenylate Cyclase Coupled ß-adrenergic Receptors, Adv. Cyclic Nucleotide Res, 9: 1.
Limbird, L.E., Gill, D.M., and Lefkowitz, R.J., 1980, Agonist-promoted Coupling of the ß-adrenergic Receptor with the Guanine Nucleotide Regulatory Protein of the Adenylate Cyclase System, Proc. Nat. Acad. Sci. U.S.A, 77: 775.
Limbird, L.E., and Lefkowitz, R.J., 1977, Resolution of ß-adrenergic Receptor Binding and Adenylate Cyclase Activity by Gel-exclusion Chromatography, J. Bio. Chem, 252: 799.
Limbird, L.E. and Lefkowitz, R.J., 1978, Agonist-induced Increase in Apparent ß-adrenergic Receptor Size, Proc. Nat. Acad. Sci. U.S.A 75: 228.
Maguire, M.E., Ross, E.M., and Gilman, A.G., 1977, ß-adrenergic Receptor: Ligand Binding Properties and the Interaction with Adenylyl Cyclase, Adv. Cyc. Nucleotide Res, 8: 1.
Maguire, M.E., Van Arsdale, P.M., and Gilman, A.G., 1976, An Agonistspecific Effect of Guanine Nucleotides on Binding to the ß-adrenergic Receptor, Mol. Pharmacol 12: 335.
Mallorga, P., Tallman, J.F., Henneberry, R.C., Hirata, F., Stritt-matter, W.T., and Axelrod, J., 1980, Mepacrine Blocks ß-adrenergic Agonist-induced Desensitization in Astrocytoma Cells, Proc. Nat. Acad. Sci. U.S.A, 77: 1341.
Mickey, J.V., Tate, R., Mullikin, D., and Lefkowitz, R.J., 1976, Regulation of Adenylate Cyclase-coupled ß-adrenergic Receptor Binding Sites by ß-adrenergic Catecholamines in Vitro, Mol. Pharmacol 12: 409.
Mukherjee, C., Caron, M.G., and Lefkowitz, R.J., 1975, Catecholamineinduced Subsensitivity of Adenylate Cyclase Associated with Loss of ß-adrenergic Receptor Binding Sites, Proc. Nat. Acad. Sci. U.S.A, 72: 1945.
Nickols, G.A. and Brooker, G., 1979, Induction of Refractoriness to Isoproterenol by Prior Treatment of C6–2B Rat Astrocytoma Cells with Cholera Toxin, J. Cyc. Nucleotide Res, 5: 435.
Northup, J.K., Sternweis, P.C., Smigel, M.D., Schleifer, L.S., and Gilman, A.G., 1980, Purification of the Regulatory Component of Adenylate Cyclase, Proc. Nat. Acad. Sci, 77: 6516.
Orly, J. and Schramm, M., 1976, Coupling of Catecholamine Receptor from One Cell with Adenylate Cyclase from Another Cell by Cell Fusion, Proc. Nat. Acad. Sci., U.S.A, 73: 4410.
Pastan, I.H. and Willingham, M.C., 1981, Receptor-mediated Endocytosis of Hormones in Cultured Cells, Ann. Rev. Physiol, 43: 239.
Perkins, J.P., Su, Y-F., and Harden, T.K., 1979, Adaptive Changes in the Responsiveness of Adenylate Cyclase to Catecholamines, Drug and Alcohol Dependence, 4: 279.
Reggiani, A, Vernaleone, F., and Robison, G.A., 1980, Loss and Restoration of Sensitivity to Catecholamines in Cultured BHK Cells: Influence of Dansylcadavarine, Soc. Neuroscience Abst, 6: 183.
Rodbell, M., 1980, The Role of Hormone Receptors and GTP-regulatory Proteins in Membrane Transduction, Nature, 284: 17.
Ross, E.M. and Gilman, A.G., 1980, Biochemical Properties of Hormone-sensitive Adenylate Cyclase, Ann. Rev. Biochem, 49: 533.
Ross, E.M., Howlett, A.C., Ferguson, K.M., and Gilman, A.G., 1978, Reconstitution of Hormone-sensitive Adenylate Cyclase Activity with Resolved Components of the Enzyme, J. Bio. Chem, 253: 6401.
Schramm, M. and Rodbell, M., 1975, Persistent Active State of the Adenylate Cyclase System Produced by the Combined Actions of Isoproterenol and Guanylyl Imidodiphosphate in Frog Erythrocyte Membranes, J. Bio. Chem, 250: 2232.
Shear, M., Insel, P.A., Melmon, K.L., and Coffino, P., 1976, Agonistspecific Refractoriness Induced by Isoproterenol, J. Biol. Chem 251: 7572.
Sternweis, P.C. and Gilman, A.G., 1979, Reconstitution of Catechol-amine-sensitive Adenylate Cyclase, J. Bio. Chem, 254: 3333.
Su, Y-F., Cubeddu-Ximenez, L., and Perkins, J.P., 1976a, Regulation of Adenosine 3’:5’-monophosphate Content of Human Astrocytoma Cells: Desensitization to Catecholamines and Prostaglandins, J. Cyc. Nucleotide Res, 2: 257.
Su, Y-F., Harden, T.K., and Perkins, J.P., 1980, Catecholamine-specific Desensitization of Adenylate Cyclase: Evidence for a Multistep Process, J. Bio. Chem, 255: 7410.
Terasaki, W.L., Brooker, G., de Vellis, J., Inglish, D., Hsu, C-Y.,and Moylan, R.D., 1978, Involvement of Cyclic AMP and Protein Synthesis in Catecholamine Refractoriness, Adv. Cyc. Nucleotide Res., 9: 33.
Vauquelin, G., Geynet, P., Hanoune, J., and Strosberg, A.S., 1977, Isolation of Adenylate Cyclase-free, ß-adrenergic Receptor from Turkey Erythrocyte Membranes by Affinity Chromatography, Proc. Nat. Acad. Sci. U.S.A, 74: 3710.
Wessels, M.R., Mullikin, D., and Lefkowitz, R.J., 1979, Selective Alteration in High Affinity Agonist Binding: A Mechanism of ß-adrenergic Receptor Desensitization, Mol. Pharmacol, 16: 10.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer Science+Business Media New York
About this chapter
Cite this chapter
Perkins, J.P. (1982). Regulation of the Responsiveness of Adenylate Cyclase to Catecholamines. In: Swillens, S., Dumont, J.E. (eds) Cell Regulation by Intracellular Signals. NATO Advanced Study Institutes Series, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7718-4_2
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7718-4_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7720-7
Online ISBN: 978-1-4684-7718-4
eBook Packages: Springer Book Archive