Abstract
Secretion is a fundamental activity of complex organisms. Some cells are highly specialized in the synthesis and export of secretory products, e.g., the pancreatic exocrine cell, the β cell of the pancreatic islet, the mast cell, the chromaffin cell of the adrenal medulla, the acinar cell of the salivary gland. But the intracellular machinery for secretion appears to exist in all cell types except the erythrocyte.
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Bibliography
G. Palade, Intracellular aspects of the process of protein synthesis, Science 189: 347 (1975).
W.W. Douglas and R.P. Rubin, The role of calcium in the secretory response of the adrenal medulla to acetylcholine, J. Physiol. 159: 40 (1961).
A. Sandow, Excitation-contraction coupling in muscular response, Yale J. Biol. Med. 25: 176 (1952).
W.W. Douglas, Stimulus-secretion coupling: the concept and clues from chromaffin and other cells, Br. J. Pharmac. 34: 451 (1968).
E.K. Matthews, Calcium translocation and control mechanisms for endocrine secretion, in: Secretory Mechanisms, Society for Experimental Biology Symposium XXXIII, C.R. Hopkins and C.J. Duncan, eds., Cambridge University Press, p. 225 (1979).
W.W. Douglas, The role of calcium in stimulus-secretion coupling, in: Stimulus-Secretion Coupling in the Gastrointestinal Tract, R.M. Case and H. Goebell, eds., MTP Press Ltd, Lancaster, England, p. 17 (1976).
H. Rasmussen, G. Clayberger and M.C. Gustin, The messenger function of calcium in cell activation, in: Secretory Mechanisms, Society for Experimental Biology Symposium XXXIII, C.R. Hopkins and C.J. Duncan, eds, Cambridge University Press, p. 161 (1979).
M. Schramm and Z. Selinger, Neurotransmitters, receptors, second messengers and responses in parotid gland and pancreas, in: Stimulus-Secretion Coupling in the Gastrointestinal Tract, R.M. Case and H. Goebell, eds, MTP Press Ltd, Lancaster, England, p. 49 (1976).
T.B. Bolton, Mechanisms of action of transmitters and other substances on smooth muscle, Phys. Revs. 59: 606 (1979).
R.H. Michell, Inositol phospholipids and cell surface receptor function, Biochim. Biophys. Acta 415: 81 (1975).
R.H. Michell, Inositol phospholipids in membrane function, Trends in Biochemical Science 4: 128 (1979).
M.J. Berridge and J.N. Fain, Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine, Biochem. J. 178: 59 (1979).
B. Satir, The final steps in secretion, Sci. Am. 233: 28 (October 1975).
E. Lazarides and J.P. Revel, The molecular basis of cell movement, Sci. Am. 240: 88 (May 1979).
O.I. Stendhal and T.P. Stossel, Actin-binding protein amplifies actomyosin contraction and gelsolin confers calcium control on the direction of contraction, Biochem. Biophys. Res. Comm. 92: 675 (1980).
M. Gratzl and G. Dahl, Cat+-induced fusion of Golgi-derived Secretory vesicles isolated from rat liver, FEBS Letters 62: 142 (1976).
D. Allan and R.H. Michell, The possible role of lipids in control of membrane fusion during secretion, in: Secretory Mechanisms, Society for Experimental Biology Symposium XXXIII, C.R. Hopkins and C.J. Duncan, eds., Cambridge University Press, p. 323 (1979).
I.M. Goldstein, J.K. Horn, H.B. Kaplan and G. Weissmann, Calcium-induced lysozyme secretion from human polymorphonuclear leukocytes, Biochem. Biophys. Res. Comm. 60: 807 (1974).
D.G. Wright and J.I. Gallin, Secretory responses of human neutrophils: Exocytosis of specific (secondary) granules by human neutrophils during adherence in vitro and during exudation in vivo, J. Immunol. 123: 285 (1979).
D.G. Wright and J.I. Gallin, A functional differentiation of human neutrophil granules: Generation of C5a by a specific (secondary) granule product and inactivation of C5a by azurophil (primary) granule products, J. Immunol. 119: 1068 (1977).
R.B. Zurier, S. Hoffstein and G. Weissman, Cytochalasin B: effect on lysosomal enzyme release from human leucocytes, Proc. Natl. Acad. Sci. 70: 844 (1973).
G. Zabucchi, R. Soranzo, F. Rossi and D. Romeo, Exocytosis in human polymorphonuclear leukocytes induced by A23187 and calcium, FEBS Letters, 54: 44 (1975).
E. Schell-Frederick, Stimulation of the oxidative metabolism of polymorphonuclear leucocytes by the calcium ionophore A23187, FEBS Letters 48: 37 (1974).
D.G. Wright, D.A. Bralove and H.I. Gallin, The differential mobilization of human neutrophil granules: Effects of phorbol myristate acetate and ionophore A23187, Am. J. Pathol. 87: 273 (1977).
P.H. Naccache, H.J. Showell, E.L. Becker and R.I. Sha’afi, Changes in ionic movements across rabbit pholymorphonuclear leukocyte membranes during lysosomal enzyme release: Possible ionic basis for lysosomal enzyme release, J. Cell Biol. 75: 635 (1977).
S. Hoffstein, Ultrastructural demonstration of calcium loss from local regions of the plasma membrane of surface-stimulated human granulocytes, J. Immunol. 123: 1395 (1979).
A. Barthelemy, R. Paridaens and E. Schell-Frederick, PhagocytosisInduced 45calcium efflux in polymorphonuclear leucocytes, FEBS Letters 82: 283 (1977).
T.P. Stossel, J.H. Hartwig, H.L. Yin and O. Stendahl, The motor of amoeboid leucocytes, Biochem. Soc. Symp. 45: 51 (1980).
J.H. Hartwig and T.P. Stossel, Interactions of actin, myosin, and an actin-binding protein of rabbit pulmonary macrophages III effects of cytochalasin B, J. Cell Biol. 71: 295 (1976).
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Schell-Frederick, E. (1982). The Central Role of Calcium in Stimulus-Secretion Coupling: General Concepts and the Specialized Example of the Polymorphonuclear Leukocyte. In: Swillens, S., Dumont, J.E. (eds) Cell Regulation by Intracellular Signals. NATO Advanced Study Institutes Series, vol 44. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7718-4_16
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DOI: https://doi.org/10.1007/978-1-4684-7718-4_16
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