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Glucagon

  • Chapter
The Year in Metabolism 1975–1976

Abstract

True glucagon, i.e., the 3485 mol. wt. biologically active immunoreactive polypeptide present in pancreas, appears to have the same amino acid sequence in all the mammalian species thus far studied—pork (Bromer (et al., 1957), beef (Bromer et al., 1971), man (Thomsen et al., 1972), rat (Sundby and Markussen, 1971), and rabbit (Sundby and Markussen, 1972)—suggesting the possible importance of these primary structural features. The primary sequences of avian glucagons differ (Markussen et al., 1972; Sundby et al., 1972; Pollock and Kimmel, 1975), and these differences appear to influence their immunological properties (Markus-sen et al., 1972).

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References

  • Alberti, K. G. M. M., Christensen, N. J., Christensen, S. E., Hansen, A. P., Iversen, J., Lundbaek, K., Seyer-Hansen, K., and Orskov, H., 1973, Inhibition of insulin secretion by somatostatin, Lancet 2: 1299.

    Article  PubMed  CAS  Google Scholar 

  • Alberti, K. G. M. M., Christensen, N. J., Iversen, J., and Orskov, H., 1975, Role of glucagon and other hormones in development of diabetic ketoacidosis, Lancet 1: 1307.

    Article  PubMed  CAS  Google Scholar 

  • Amherdt, M., Harris, V., Renold, A. E., Orci, L., and Unger, R. H., 1974, Hepatic autophagy in uncontrolled experimental diabetes and its relationships to insulin and glucagon, J. Clin. Invest. 54: 188.

    Article  PubMed  CAS  Google Scholar 

  • Arimura, A., Sato, H., Dupont, A., Nishi, N., and Schally, A. V., 1975, Somatostatin: Abundance of immunoreactive hormone in rat stomach and pancreas, Science 189: 1007.

    Article  PubMed  CAS  Google Scholar 

  • Aronoff, S., Bennett, P. H., Rushforth, M. B., Miller, M., and Unger, R. H., 1976, Glucagon response to arginine infusion in “prediabetic” Pima Indians, Diabetes (in press).

    Google Scholar 

  • Assan, R., 1972, In vivo metabolism of glucagon, in: Glucagon: Molecular Physiology, Clinical and Therapeutic Implications (P. J. Lefebvre and R. H. Unger, eds.), pp. 47–59, Pergamon Press, Oxford.

    Google Scholar 

  • Baetens, D., Rufener, C., Srikant, B. C., Dobbs, R. E., Unger, R. H., and Orci, L., 1976a, Identification of glucagon-producing cells (A-cells) in dog gastric mucosa, J. Cell Biol. 69: 455.

    Article  PubMed  CAS  Google Scholar 

  • Baetens, D., Rufener, C., Unger, R. H., Renold, A. E., and Orci, L., 1976b, Identification par immunocytochimie de la cellule secretant le glucagon dans la muqueuse gastrique, C. R. Acad. Sci. Paris 282: 195.

    CAS  Google Scholar 

  • Barnes, A. J., and Bloom, S. R., 1976, Pancreatectomised man: A model for diabetes without glucagon, Lancet 1: 219.

    Article  PubMed  CAS  Google Scholar 

  • Bilbrey, G. L., Faloona, G. R., White, M. C., and Knochel, J. P., 1974, Hyperglucagonemia of renal failure, J. Clin. Invest. 53: 841.

    Article  PubMed  CAS  Google Scholar 

  • Blackard, W. G., Nelson N. C., and Andrews, S. S., 1974, Portal and peripheral vein immunoreactive glucagon concentrations after arginine or glucose infusions, Diabetes 23: 199.

    PubMed  CAS  Google Scholar 

  • Böttger, I., Schlein, E., Faloona, G. R., Knochel, J. P., and Unger, R. H., 1972, The effect of exercise on glucagon secretion, J. Clin. Endocrinol. Metab. 35: 117.

    Article  PubMed  Google Scholar 

  • Braaten, J. T., Shenk, A., Lee, M. J., McGuigan, J. E., and Mintz, D. H., 1974, Cyclic nucleotide—mediated secretion of glucagon and gastrin in monolayer culture of rat pancreas, J. Clin. Invest. 53: 10A.

    Article  Google Scholar 

  • Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., and Guillemin, R., 1973, Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone, Science 179: 77.

    Article  PubMed  CAS  Google Scholar 

  • Brockman, R. P., and Bergman, E. N., 1975, Effect of glucagon on plasma alanine and glutamine metabolism and hepatic gluconeogenesis in sheep, Amer. J. PhNsiol. 228: 1627.

    CAS  Google Scholar 

  • Bromer, W. W., Sinn, L. G., and Behrens, O. K., 1957, The amino acid sequence of glucagon. V. Location of amide groups, acid degradation studies, and summary of sequential evidence, J. Amer. Chem. Soc. 79: 2807.

    Article  CAS  Google Scholar 

  • Bromer, W. W., Boucher, M. E., and Koffenberger, J. E., Jr., 1971, Amino acid sequence of bovine glucagon, J. Biol. Chem. 246: 2822.

    PubMed  CAS  Google Scholar 

  • Buchanan, K. D., and McCarroll, A. M., 1972, Abnormalities of glucagon metabolism in untreated diabetes mellitus, Lancet 2: 1394.

    Article  PubMed  CAS  Google Scholar 

  • Chiasson, J. L., Liljenquist, J. E., Sinclair-Smith, B. C., and Lacy, W. W., 1975, Gluconeogenesis from alanine in normal postabsorptive man. Intrahepatic stimulatory effect of glucagon, Diabetes 24: 574.

    Article  PubMed  CAS  Google Scholar 

  • Chideckel, E. W., Palmer, J., Koerker, D. J., Ensinck, J., Davidson, M. B., and Goodner, C. J., 1975, Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis, J. Clin. Invest. 55: 754.

    Article  PubMed  CAS  Google Scholar 

  • Cuatrecasas, P., Jacobs, S., and Bennett, V., 1975, Activation of adenylate cyclase by phosphoramidate and phosphonate analogs of GTP: Possible role of covalent enzyme—substrate intermediates in the mechanism of hormonal activation, Proc. Nat. Acad. Sci. U.S.A. 72: 1739.

    Article  CAS  Google Scholar 

  • Daniel, R. R., Metzger, B. E., Freinkel, N., Faloona, G. R., Unger, R. H., and Nitzan, M., 1974, Carbohydrate metabolism in pregnancy. XI. Response of plasma glucagon to overnight fast and oral glucose during normal pregnancy and in gestational diabetes, Diabetes 23: 771.

    PubMed  CAS  Google Scholar 

  • Day, J. L., and Tattersall, R. B., 1975, Glucagon secretion in unaffected monozygotic twins of juvenile diabetics, Metabolism 24: 145.

    Article  PubMed  CAS  Google Scholar 

  • Dencker, H., Hedner, P., Holst, J., and Tranberg, K. G., 1975, Pancreatic glucagon response to an ordinary meal, Scand. J. Gastroenterol. 10: 471.

    PubMed  CAS  Google Scholar 

  • Dobbs, R., Sakurai, H., Sasaki, H., Faloona, G., Valverde, I., Baetens, D., Orci, L., and Unger, R., 1975, Glucagon: Role in the hyperglycemia of diabetes mellitus, Science 187: 544.

    Article  PubMed  CAS  Google Scholar 

  • Dubois, M. P., 1975, Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas, Proc. Nat. Acad. Sci. U.S.A. 72: 1340.

    Article  CAS  Google Scholar 

  • Duckworth, W. C., and Kitabchi, A. E., 1974, Insulin and glucagon degradation by the same enzyme, Diabetes 23: 536.

    PubMed  CAS  Google Scholar 

  • Dudrick, S. J., Long, J. M., Steiger, E., and Rhoads, J. E., 1970, Intravenous hyperalimentation, Med. Clin. North Amer. 54: 577.

    Google Scholar 

  • Edwards, J. C., Howell, S. L., and Taylor, K. W., 1970, Radioimmunoassay of glucagon release from isolated guinea-pig islets of Langerhans incubated in vitro, Biochem. Biophys. Acta 215: 297.

    Article  PubMed  CAS  Google Scholar 

  • Felig, P., Gusberg, R., Hendler, R., Gump, F. E., and Kinney, J. M., 1974, Concentrations of glucagon and the insulin: glucagon ratio in the portal and peripheral circulation (38386), Proc. Soc. Exp. Biol. Med. 147: 88.

    PubMed  CAS  Google Scholar 

  • Ferner, H., 1953, The A- and B-cells of the pancreatic islets as sources of the antagonistic hormones glucagon and insulin. The shift of the AB-relation in diabetes mellitus, Amer. J. Dig. Dis. 20: 301.

    Article  PubMed  CAS  Google Scholar 

  • Frame, C. M., Davidson, M. B., and Sturdevant, R. A. L., 1975, Effects of the octapeptide of cholecystokinin on insulin and glucagon secretion in the dog, Endocrinology 97: 549.

    Article  PubMed  CAS  Google Scholar 

  • Fujita, T., 1976, The 1975 International Symposium of the GEP Endocrine System,Elsevier Scientific Publishing, Kyoto, Japan (in press).

    Google Scholar 

  • Galbo, H., Holst, J. J., and Christensen, N. J., 1975, Glucagon and plasma catecholamine responses to graded and prolonged exercise in man, J. Appl. Physiol. 38: 70.

    PubMed  CAS  Google Scholar 

  • Garrison, J. C., and Haynes, R. C., Jr., 1975, The hormonal control of gluconeogenesis by regulation of mitochondrial pyruvate carboxylation in isolated rat liver cells, J. Biol. Chem. 250: 2769.

    PubMed  CAS  Google Scholar 

  • Gerich, J. E., Lorenzi, M., Bier, D. M., Schneider, V., Tsalikian, E., Karam, J. H., and Forsham, P. H., 1975a, Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon, N. Engl. J. Med. 292: 985.

    Article  PubMed  CAS  Google Scholar 

  • Gerich, J. E., Lorenzi, M., Hane, S., Gustafson, G., Guillemin, R., and Forsham, P. H., 1975b, Evidence for a physiologic role of pancreatic glucagon in human glucose homeostasis: Studies with somatostatin, Metabolism 24: 175.

    Article  PubMed  CAS  Google Scholar 

  • Gerich, J. E., Lorenzi, M., Karam, J. H., Schneider, V., and Forsham, P. H., 1975c, Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus, J. Amer. Med. Assoc. 234: 159.

    Article  CAS  Google Scholar 

  • Gerich, J. E., Lovinger, R., and Grodsky, G. M., 1975d, Inhibition by somatostatin of glucagon and insulin release from the perfused rat pancreas in response to arginine, isoproterenol and theophylline: Evidence for a preferential effect on glucagon secretion, Endocrinology 96: 749.

    Article  PubMed  CAS  Google Scholar 

  • Gössner, W., and Korting, G. W., 1960, Metastasierendes Inselzellkarzinom von A-Zelltyp bei einem Fall von Pemphigus foliaceus mit Diabetes renalis, Dtsch. Med. Wochenschr. 85: 434.

    Article  Google Scholar 

  • Hinton, P., Allison, S. P., Littlejohn, S., and Lloyd, J., 1971, Insulin and glucose to reduce catabolic response to injury in burned patients, Lancet 1: 767.

    Article  PubMed  CAS  Google Scholar 

  • Iversen, J., 1973a, Adrenergic receptors in the secretion of glucagon and insulin from the isolated perfused canine pancreas, J. Clin. Invest. 52: 2102.

    Article  PubMed  CAS  Google Scholar 

  • Iversen, J., 1973b, Effect of acetyl choline on the secretion of glucagon and insulin from the isolated perfused canine pancreas, Diabetes 22: 381.

    PubMed  CAS  Google Scholar 

  • Iversen, J., 1974, Inhibition of pancreatic glucagon release by somatostatin: In vitro, Scand. J. Clin. Lab. Invest. 33: 125.

    Article  PubMed  CAS  Google Scholar 

  • Iversen, J., 1970, Program of the Seventh Congress of the International Diabetes Federation, International Congress Series 209:46 (F. J. G. Ebling, I. Henderson, and R. Assan, eds.), Excerpta Medica, Amsterdam.

    Google Scholar 

  • Järhult, J., 1975, Role of the symphato–adrenal system in hemorrhagic hyperglycemia, Acta Physiol. Scand. 93: 25.

    Article  PubMed  Google Scholar 

  • Jennings, A. S., Cherrington, A. D., Chiasson, J. L., Liljenquist, J. E., and Lacy, W. W., 1975, The fine regulation of basal hepatic glucose production, Clin. Res. 23: 323A.

    Google Scholar 

  • Kakiuchi, S., and Tomizawa, H. H., 1964, Properties of a glucagon-degrading enzyme of beef liver, J. Biol. Chem. 239: 2160.

    PubMed  CAS  Google Scholar 

  • Kaneto, A., Kajinuma, H., and Kosaka, K., 1975, Effect of splanchnic nerve stimulation on glucagon and insulin output in the dog, Endocrinology 96: 143.

    Article  PubMed  CAS  Google Scholar 

  • Kirk, R. D., Dunn, P. J., Smith, J. R., Beaven, D. W., and Donald, R. A., 1975, Abnormal pancreatic alpha-cell function in first-degree relatives of known diabetics, J. Clin. Endocrinol. Metab. 40: 913.

    Article  PubMed  CAS  Google Scholar 

  • Koerker, D. J., Ruch, W., Chideckel, E., Palmer, J., Goodner, C. J., Ensinck, J., and Gale, C. C., 1974, Somatostatin: Hypothalamic inhibitor of the endocrine pancreas, Science 184: 482.

    Article  PubMed  CAS  Google Scholar 

  • Kuku, S. F., Zeidler, A., Emmanouel, D. S., Katz, A. I., Levin, N. W., Tello, A., and Rubenstein, A. H., 1976. Heterogeneity of circulating glucagon in renal failure and diabetic hyperglycemic syndromes, Clin. Res. 23: 536A.

    Google Scholar 

  • Lacy, P. E., 1970, Beta-cell secretion—function from the standpoint of pathologist (Banting Memorial Lecture), Diabetes 19: 895.

    PubMed  CAS  Google Scholar 

  • Larsson, L. I., Holst, J., Häkanson, R., and Sundler, F., 1975, Distribution and properties of glucagon immunoreactivity in the digestive tract of various mammals: An immunohistochemical and immunochemical study, Histochemistry 44: 281.

    Article  PubMed  CAS  Google Scholar 

  • Lawrence, A. M., Kirsteins, L., Hojvat, S., Rubin, L., and Paloyan, V., 1975, Salivary gland glucagon: A potent extrapancreatic hyperglycemic factor, Clin. Res. 23: 536A.

    Google Scholar 

  • Leclercq-Meyer, V., Rebolledo, O., Marchano, J., and Malaisse, W., 1975, Glucagon release: Paradoxical stimulation by glucose during calcium deprivation, Science 189: 897.

    Article  PubMed  CAS  Google Scholar 

  • Lefebvre, P. J., and Luyckx, A. S., 1975, Effect of acute kidney exclusion by ligation of renal arteries on peripheral plasma glucagon levels and pancreatic glucagon production in the anesthetized dog, Metabolism 24: 1169.

    Article  PubMed  CAS  Google Scholar 

  • Lefebvre, P. J., and Luyckx, A. S., 1976, Plasma glucagon after kidney exclusion: Experiments in somatostatin-infused and in eviscerated dogs, Metabolism 25: 761.

    Article  PubMed  CAS  Google Scholar 

  • Leffert, H., Alexander, N. M., Faloona, G. R., Rubalcava, B., Steiner, A., and Unger, R. H., 1975, Specific endocrine and hormonal receptor changes associated with liver regeneration in adult rats, Proc. Nat. Acad. Sci. U.S.A. 72: 4033.

    Article  CAS  Google Scholar 

  • Lin, M. C., Wright, D. E., Hruby, V. J., and Rodbell, M., 1975, Structure–function relationships in glucagon: Properties of highly purified DES-HIS-1-, monoiodo-, and (DES-ASN-28, THR-29) (homoserine lactone-27)-glucagon, Biochemistry 14: 1559.

    Article  PubMed  CAS  Google Scholar 

  • Lindsey, C. A., Santeusanio, F., Braaten, J., Faloona, G. R., and Unger, R. H., 1974, Pancreatic alpha cell function in trauma, J. Amer. Med. Assoc. 227: 757.

    Article  CAS  Google Scholar 

  • Lindsey, C. A., Faloona, G. R., and Unger, R. H., 1975, Plasma glucagon levels during rapid exsanguination with and without adrenergic blockade, Diabetes 24: 313.

    Article  PubMed  CAS  Google Scholar 

  • Luft, R., Efendic, S., Hökfelt, T., Johansson, O., and Arimura, A., 1974, Immunohistochemical evidence for the localization of somatostatin-like immunoreactivity in a cell population of the pancreatic islets, Med. Biol. 52: 428.

    PubMed  CAS  Google Scholar 

  • Mackrell, D. J., and Sokal, J. E., 1969, Antagonism between the effects of insulin and glucagon on the isolated liver, Diabetes 18: 724.

    PubMed  CAS  Google Scholar 

  • Madison, L. L., Seyffert, W. A., Jr., Unger R. H., and Barker, B., 1968, Effect of plasma free fatty acids on plasma glucagon and serum insulin concentrations, Metabolism 17: 301.

    Article  PubMed  CAS  Google Scholar 

  • Mallison, C. N., Bloom, S. R., Warin, A. P., Salmon, P. R., and Cox, B., 1974, A glucagonoma syndrome, Lancet 2: 1.

    Article  Google Scholar 

  • Marco, J., Calle, C., Roman, D., Diaz-Fierros, M., Villanueva, M. L., and Valverde, I., 1973, Hyperglucagonism induced by glucocorticoid treatment in man, N. Engl. J. Med. 288: 128.

    Article  PubMed  CAS  Google Scholar 

  • Markussen, J., Frandsen, E., Heding, L. G., and Sundby, F., 1972, Turkey glucagon: Crystallization, amino acid composition, and immunology, Harm. Metab. Res. 4: 360.

    Article  CAS  Google Scholar 

  • Marliss, E. B., Girardier, L., Seydoux, J., Wollheim, C. B., Kanazawa, Y., Orci, L., Renold, A. E., and Porte, D., Jr., 1973, Glucagon release induced by pancreatic nerve stimulation in the dog, J. Clin. Invest. 52: 1246.

    Article  PubMed  CAS  Google Scholar 

  • Mashiter, K., Harding, P. E., Chou, M., Mashiter, G. D., Stout, J., Diamond, D., and Field, J. B., 1975, Persistent pancreatic glucagon but not insulin response to arginine in pancreatectomized dogs, Endocrinology 96: 678.

    Article  PubMed  CAS  Google Scholar 

  • Matschinsky, F. M., Pagliara, A. S., Hover, B. A., Haymond, M. W., and Stillings, S. N., 1975, Differential effects of a-and 13-’3-glucose on insulin and glucagon secretion from the isolated perfused rat pancreas, Diabetes 24: 369.

    Article  PubMed  CAS  Google Scholar 

  • Matsuyama, T., and Foa, P. P., 1975, Plasma glucose, insulin, pancreatic and enteroglucagon levels in normal and depancreatized dogs (38288), Proc. Soc. Exp. Biol. Med. 147: 97.

    Google Scholar 

  • McGarry, J. D., Robles-Valdes, C., and Foster, D. W., 1975a, Role of carnitine in hepatic ketogenesis, Proc. Nat. Acad. Sci. U.S.A. 72: 4385.

    Article  CAS  Google Scholar 

  • McGarry, J. D., Wright, P. H., and Foster, D. W., 1975b, Hormonal control of ketogenesis: Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon, J. Clin. Invest. 55: 1202.

    Article  PubMed  CAS  Google Scholar 

  • McGavran, M. H., Unger, R. H., Recant, L., Polk, H. C., Kilo, C., and Levin, M. E., 1966, A glucagon-secreting alpha cell carcinoma of the pancreas, N. Engl. J. Med. 274: 1408.

    Article  PubMed  CAS  Google Scholar 

  • Meguid, M. M., Brennan, M. F., Aoki, T. T., Müller, W. A., Ball, M. R., and Moor, F. D., 1973, The role of insulin and glucagon in acute trauma, Surg. Forum 24: 97.

    PubMed  CAS  Google Scholar 

  • Meissner, C., Thum, C., Beischer, W., Winkler, G. Schröder, K. E., and Pfeiffer, E. F., 1975, Antidiabetic action of somatostatin—assessed by the artificial pancreas, Diabetes 24: 988.

    Article  PubMed  CAS  Google Scholar 

  • Mortimer, C. H., Turnbridge, W. M. G., Carr, D., Yeomans, L., Lind, T., Coy, D. H., Bloom, S. R., Kastin, A., Mallinson, C. N., Besser, G. M., Schally, A. V., and Hall, R., 1974, Effects of growth hormone release–inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients, Lancet 1: 697.

    Article  PubMed  CAS  Google Scholar 

  • Müller, W. A., Faloona, G. R., Unger, R. H., and Aguilar-Parada, E., 1970, Abnormal alpha cell function in diabetes. Response to carbohydrate and protein ingestion, N. Engl. J. Med. 283: 109.

    Article  PubMed  Google Scholar 

  • Müller, W. A., Faloona, G. R., and Unger, R. H., 1971, The effect of experimental insulin deficiency on glucagon secretion, J. Clin. Invest. 50: 1992.

    Google Scholar 

  • Munoz, L., Blazquez, E., and Unger, R., 1975, Gastric A-cell function in normal and diabetic dogs, Diabetes 24: 411.

    Google Scholar 

  • Nilsson, K. O., Heding, L. G., and Hokfelt, B., 1975, The influence of short term submaximal work on the plasma concentrations of catecholamines, pancreatic glucagon, and growth hormone in man, Acta Endocrinol. KBH 79: 286.

    CAS  Google Scholar 

  • Noe, B. D., and Bauer, G. E., 1971, Evidence for glucagon biosynthesis involving a protein intermediate in islets of the anglerfish (Lophius americanus), Endocrinology 89: 642.

    Article  PubMed  CAS  Google Scholar 

  • Noe, B. D., Bauer, G. E., Steffes, M. W., Sutherland, D. E. R., and Najarian, J. S., 1975, Glucagon biosynthesis in human pancreatic islets: Preliminary evidence for a biosynthetic intermediate, Horm. Metab. Res. 7: 314.

    Article  PubMed  CAS  Google Scholar 

  • Orci, L., and Unger, R. H., 1975, Functional subdivision of islets of Langerhans and possible role of D-cells, Lancet 2: 1243.

    Article  PubMed  CAS  Google Scholar 

  • Orci, L., Pictet, R., Forssmann, W. G., Renold, A. E., and Rouiller, C., 1968, Structural evidence for glucagon producing cells in the intestinal mucosa of the rat, Diabetologia 4: 56.

    Article  PubMed  CAS  Google Scholar 

  • Orci, L., Stauffacher, W., Renold, A. E., and Rouiller, C., 1970, The ultrastructural aspect of A-cells of non-ketotic and ketotic diabetic animals: Indications for stimulation and inhibition of glucagon production, Acta. Isotopica 10: 171.

    PubMed  CAS  Google Scholar 

  • Orci, L., Unger, R. H., and Renold, A. E., 1973, Structural coupling between pancreatic islet cell, Experientia 29: 1015.

    Article  PubMed  CAS  Google Scholar 

  • Orci, L., Baetens, D., Dubois, M. P., and Rufener, C., 1975a, Evidence for the D-cell of the pancreas secreting somatostatin, Horm. Metab. Res. 7: 400.

    Article  PubMed  CAS  Google Scholar 

  • Orci, L., Malaisse-Lagae, F., Amherdt, M., Ravazzola, M., Weisswange, A., Dobbs, R., Perrelet, A., and Unger, R., 1975b, Cell contacts in human islets of Langerhans, J. Clin. Endocrinol. Metab. 41: 841.

    Article  PubMed  CAS  Google Scholar 

  • Orci, L., Malaisse-Lagae, F., Ravazzola, M., Rouiller, D., Renold, A. E., Perrelet, A., and Unger, R., 1975c, A morphological basis for intercellular communication between A- and B-cells in the endocrine pancreas, J. Clin. Invest. 56: 1066.

    Article  PubMed  CAS  Google Scholar 

  • Orci, L., Baetens, D., Rufener, C., Amherdt, M., Ravazzola, M., Studer, P., Malaisse-Lagae, F., and Unger, R. H., 1976, Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes, Proc. Nat. Acad. Sci. U.S.A. 73: 1338.

    Article  CAS  Google Scholar 

  • Orton, C. I., Segal, A. W., Bloom, S. R., and Clark, J., 1975, Hypersecretion of glucagon and gastrin in severely burnt patients, Br. Med. J. 2: 170.

    Article  PubMed  CAS  Google Scholar 

  • Palmer, J. P., Bensen, J., Werner, P., and Ensinck, J. W., 1976, Glucagon secretion in a totally pancreatectomized patient, Clin. Res. 24: 119A.

    Google Scholar 

  • Park, C. R., and Exton, J. H., 1972, Glucagon and the metabolism of glucose, in: Glucagon: Molecular Physiology, Clinical and Therapeutic Implications ( P. J. Lefebvre and R. H. Unger, eds.), pp. 77–108, Pergamon Press, Oxford.

    Google Scholar 

  • Parrilla, R., Jimenez, I., and Ayuso-Parrilla, M. S., 1975, Glucagon and insulin control in gluconeogenesis in the perfused isolated rat liver. Effects on cellular metabolite distribution, Eur. J. Biochem. 56: 375.

    Article  PubMed  CAS  Google Scholar 

  • Pelletier, G., Leclerc, R., Arimura, A., and Schally, A. V., 1975, Immunohistochemical localization of somatostatin in the rat pancreas, J. Histochem. Cytochem. 23: 699.

    Article  PubMed  CAS  Google Scholar 

  • Polak, J. M., Bloom, S., Coulling, I., and Pearse, A. G. E., 1971, Immunofluorescent localization of enteroglucagon cells in the gastrointestinal tract of the dog, Gut 12: 311.

    Article  PubMed  CAS  Google Scholar 

  • Pollock, H. G., and Kimmel, J. R., 1975, Chicken glucagon: Isolation and amino acid sequence studies, J. Biol. Chem. 250: 9377.

    PubMed  CAS  Google Scholar 

  • Rabinovitch, A., and Dupré, J., 1974, Effects of gastric inhibitory polypeptide present in impure pancreozymin—cholecystokinin on plasma insulin and glucagon in the rat, Endocrinology 94: 1139.

    Article  PubMed  CAS  Google Scholar 

  • Raskin, P., and Unger, R. H., 1976a, Effects of exogenous glucagon in insulin-treated diabetics, Diabetes (abstract) 25: 341.

    Google Scholar 

  • Raskin, P., and Unger, R. H., 1976b, Effect of insulin and somatostatin on A-cell dysfunction in human diabetes, Clin. Res., 24: 486A.

    Google Scholar 

  • Raskin, P., Fujita, Y., and Unger, R. H., 1975, Effect of insulin—glucose infusions on plasma glucagon levels in fasting diabetics and nondiabetics, J. Clin. Invest. 56: 1132.

    Article  PubMed  CAS  Google Scholar 

  • Rigopoulou, D., Valverde, I., Marco, J., Faloona, G., and Unger, R. H., 1970, Large glucagon immunoreactivity in extracts of pancreas, J. Biol. Chem. 245: 496.

    PubMed  CAS  Google Scholar 

  • Rocha, D. M., Faloona, G. R., and Unger, R. H., 1972, Glucagon stimulating activity of twenty amino acids in dogs, J. Clin. Invest. 51: 2346.

    Article  PubMed  CAS  Google Scholar 

  • Rocha, D. M., Santeusanio, F., Faloona, G. R., and Unger, R. H., 1973, Abnormal pancreatic alpha cell function in bacterial infections, N. Engl. J. Med. 288: 700.

    Article  PubMed  CAS  Google Scholar 

  • Rodbell, M., Krans, H. M., Pohl, S. L., and Birnbaumer, L., 1971, The glucagonsensitive adenyl cyclase system in plasma membranes of rat liver. III. Binding of glucagon: Method of assay and specificity, J. Biol. Chem. 246: 1861.

    PubMed  CAS  Google Scholar 

  • Rodbell, M., Lin, M. C., and Salomon, Y., 1974, Evidence for interdependent action of glucagon and nucleotides on the hepatic adenylate cyclase system, J. Biol. Chem. 249: 59.

    PubMed  CAS  Google Scholar 

  • Rodbell, M., Lin, M. C., Salomon, Y., Londos, C., Harwood, J. P., Martin, B. L., Rendell, M., and Berman, M., 1975, Role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: Evidence of multisite transition states, in: Advances in Cyclic Nucleotide Research ( G. I. Drumond, P. Greengard, and G. A. Robison, eds.), pp. 3–30, Raven Press, New York.

    Google Scholar 

  • Rosselin, G., Jarrousse, C., Rancon, R., and Portha, P., 1973, L’AMP cyclique médiateur de la sécrétion du glucagon due aux acides aminés, C.R. Acad. Sci. Paris 276: 1017.

    CAS  Google Scholar 

  • Russell, R. C. G., Walker, C. J., and Bloom, S. R., 1975, Hyperglucagonemia in the surgical patient, Br. Med. J. 1: 10.

    Article  PubMed  CAS  Google Scholar 

  • Sakurai, H., Dobbs, R., and Unger, R. H., 1974, Somatostatin-induced changes in insulin and glucagon secretion in normal and diabetic dogs, J. Clin. Invest. 54: 1395.

    Article  PubMed  CAS  Google Scholar 

  • Sakurai, H., Dobbs, R. E., and Unger, R. H., 1975, The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus, Metabolism 24: 1287.

    Article  PubMed  CAS  Google Scholar 

  • Salomon, Y., Lin, M. C., London, C., Rendell, M., and Rodbell, M., 1975, The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucleotide activation, J. Biol. Chem. 250: 4239.

    PubMed  CAS  Google Scholar 

  • Sasagawa, T., Kobayashi, S., and Fujita, T., 1973, Electron microscopy of human GEP endocrine cells, in: Gastro-Entero-Pancreatic Endocrine System ( T. Fujita, ed.), p. 31, Igaku Shoin, Tokyo.

    Google Scholar 

  • Sasaki, K., Dockerill, S., Adamiak, D. A., Tickle, I. J., and Blundell, T., 1975a, X-ray analysis of glucagon and its relationship to receptor binding, Nature 257: 751.

    Article  PubMed  CAS  Google Scholar 

  • Sasaki, H., Rubalcava, B., Baetens, D., Blazquez, E., Srikant, C. B., Orci, L., and Unger, R. H., 1975b, Identification of glucagon in the gastrointestinal tract, J. Clin. Invest. 56: 135.

    Article  PubMed  CAS  Google Scholar 

  • Schade, D. S., and Eaton, R. P., 1975a, Modulation of fatty acid metabolism by glucagon in man. I. Effects in normal subjects, Diabetes 24: 502.

    Article  PubMed  CAS  Google Scholar 

  • Schade, D. S., and Eaton, R. P., 1975b, Modulation of fatty acid metabolism by glucagon in man. II. Effects in insulin-deficient diabetics, Diabetes 24: 510.

    Article  PubMed  CAS  Google Scholar 

  • Sherwin, R. S., Hendler, R. G., and Felig, P., 1975, Effect of ketone infusions on amino acid and nitrogen metabolism in man, J. Clin. Invest. 55: 1382.

    Article  PubMed  CAS  Google Scholar 

  • Sherwin, R. S., Fisher, M., Hendler, R., and Felig, P., 1976, Hyperglucagonemia and blood glucose regulation in normal, obese, and diabetic subjects, N. Engl. J. Med. 294: 455.

    Article  PubMed  CAS  Google Scholar 

  • Srikant, C. B., McCorkle, K., and Dobbs, R. E., 1976, A biologically active “macro`glucagon’ (IRG)” in glucagon-secreting tissues of the dog, Diabetes 25: 325.

    Google Scholar 

  • Staehelin, L. A., 1974, Structure and function of intercellular junctions, Int. Rev. Cytol. 39: 191.

    Article  PubMed  CAS  Google Scholar 

  • Starzl, T. E., Porter, K. A., Kashiwagi, N., and Putnam, C. W., 1975, Portal hepatotrophic factors, diabetes mellitus, and acute liver atrophy, hypertrophy, and regeneration, Surg. Gynecol. Obstet. 141: 843.

    PubMed  CAS  Google Scholar 

  • Sundby, F., and Markussen, J., 1971, Isolation, crystallization, and amino acid composition of rat glucagon, Horm. Metab. Res. 3: 184.

    Article  PubMed  CAS  Google Scholar 

  • Sundby, F., and Markussen, J., 1972, Rabbit glucagon: Isolation, crystallization, and amino acid composition, Horm. Metab. Res. 4: 56.

    Article  PubMed  CAS  Google Scholar 

  • Sundby, F., Frandsen, E. K., Thomsen, J., Kristiansen, K., and Brundfeldt, K., 1972, Crystallization and amino acid sequence of duck glucagon, FEBS Lett. 26: 289.

    Article  PubMed  CAS  Google Scholar 

  • Sutherland, E. W., and DeDuve, C., 1948, Origin and distribution of the hyperglycemic—glycogenolytic factor of the pancreas, J. Biol. Chem. 175: 663.

    PubMed  CAS  Google Scholar 

  • Tager, H. S., and Steiner, D. F., 1973, Isolation of a glucagon-containing peptide: Primary structure of a possible fragment of proglucagon, Proc. Nat. Acad. Sci. U.S.A. 70: 2321.

    Article  CAS  Google Scholar 

  • Thomsen, J., Kristiansen, K., Brunfeldt, K., and Sundby, F., 1972, The amino acid sequence of human glucagon, FEBS Lett. 21: 315.

    Article  PubMed  CAS  Google Scholar 

  • Toyota, T., Sato, S., Kudo, M., Abe, K., and Goto, Y., 1975, Secretory regulation of endocrine pancreas: Cyclic AMP and glucagon secretion, J. Clin. Endocrinol. Metab. 41: 81.

    Article  PubMed  CAS  Google Scholar 

  • Trakatellis, A. C., Tada, K., Yamaji, K., and Gardiki-Kouidou, P., 1975, Isolation and partial characterization of anglerfish proglucagon, Biochemistry 14 (8): 1508.

    Article  PubMed  CAS  Google Scholar 

  • Unger, R. H., 1971, Glucagon and the insulin: glucagon ratio in diabetes and other catabolic illnesses, Diabetes 20: 834.

    PubMed  CAS  Google Scholar 

  • Unger, R. H., 1976, Diabetes and the alpha cell (Banting Memorial Lecture), Diabetes 25: 136.

    PubMed  CAS  Google Scholar 

  • Unger, R. H., and Eisentraut, A. M., 1969, Entero-insular axis, Arc. Intern. Med. 123: 261.

    Article  CAS  Google Scholar 

  • Unger, R. H., and Orci, L., 1975, The essential role of glucagon in the pathogenesis of diabetes mellitus, Lancet 1: 14.

    Article  PubMed  CAS  Google Scholar 

  • Unger, R. H., Ketterer, H., Dupré, J., and Eisentraut, A. M., 1967, The effects of secretin, pancreozymin, and gastrin on insulin and glucagon secretion in anesthetized dogs, J. Clin. Invest. 46: 630.

    Article  PubMed  CAS  Google Scholar 

  • Unger, R. H., Ohneda, A., Aguilar-Parada, E., and Eisentraut, A. M., 1969, The role of aminogenic glucagon secretion in blood glucose homeostasis, J. Clin. Invest. 48: 810.

    Article  PubMed  CAS  Google Scholar 

  • Unger, R. H., Aguilar-Parada, E., Müller, W. A., and Eisentraut, A. M., 1970, Studies of pancreatic alpha cell function in normal and diabetic subjects, J. Clin. Invest. 49: 837.

    Article  PubMed  CAS  Google Scholar 

  • Unger, R. H., Madison, L. L., and Müller, W. A., 1972, Abnormal alpha cell function in diabetics: Response to insulin, Diabetes 21: 301.

    Google Scholar 

  • Valverde, I., Villanueva, M. L., Lozano, I., and Marco, J., 1974, Presence of glucagon immunoreactivity in the globulin fraction of human plasma (“Big Plasma Glucagon”), J. Clin. Endocrinol. Metab. 39: 1090.

    Article  PubMed  CAS  Google Scholar 

  • Valverde, I., Dobbs, R., and Unger, R. H., 1975, Heterogeneity of plasma glucagon immunoreactivity in normal, depancreatized, and alloxan diabetic dogs, Metabolism 24: 1021.

    Article  PubMed  CAS  Google Scholar 

  • Valverde, I., Lemon, H. M., Kessinger, A., and Unger, R. H., 1976, Distribution of plasma glucagon immunoreactivity in a patient with a suspected glucagonoma, J. Clin. Endocrinol. Metab. 42: 804.

    Article  PubMed  CAS  Google Scholar 

  • Vranic, M., Pek, S., and Kawamori, R., 1974, Increased “glucagon immunoreactivity” (IRG) in plasma of totally depancreatized dogs, Diabetes 23: 905.

    PubMed  CAS  Google Scholar 

  • Weir, G. C., Turner, R. C., Martin, D. B., 1973, Glucagon radioimmunoassay using antiserum 30K: Interference by plasma, Norm. Metab. Res. 5: 241.

    Article  CAS  Google Scholar 

  • Weir, G. C., Knowlton, S. D., and Martin, D. B., 1975, Nucleotide and nucleoside stimulation of glucagon secretion, Endocrinology 97: 932.

    Article  PubMed  CAS  Google Scholar 

  • Willerson, J. T., Hutcheson, D. R., Leshin, S. J., Faloona, G. R., and Unger, R. H., 1974, Serum glucagon and insulin levels and their relationship to blood glucose values in patients with acute myocardial infarction and acute coronary insufficiency, Am. J. Med. 57: 747.

    Article  PubMed  CAS  Google Scholar 

  • Wilmore, D. W., Lindsey, C. A., Faloona, G. R., Moylan, J. A., Pruitt, B. A., Unger, R. H., 1974, Hyperglucagonemia after burns, Lancet 1: 73.

    Article  PubMed  CAS  Google Scholar 

  • Wise, J. K., Hendler, R., and Felig, P., 1973, Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man, J. Clin. Invest. 52: 2774.

    Article  PubMed  CAS  Google Scholar 

  • Wollheim, C. B., Blondel, B., Rabinovitch, A., and Renold, A. E., 1973, Insulin and glucagon release in pancreatic monolayer cultures: Effects of cyclic nucleotides, in: Eighth Congress of the International Diabetes Federation, Brussels, p. 48, International Congress Series No. 280, Excerpta Medica, Abstracts.

    Google Scholar 

  • Yoshinaga, T., Okuno, G., Shinji, Y., Tsujii, T., and Nishikawa, M., 1966, Pancreatic A-cell tumor associated with severe diabetes mellitus, Diabetes 15: 709.

    PubMed  CAS  Google Scholar 

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  1. University of Texas Southwestern Medical School and Veterans Administration Hospital, Dallas, Texas, 75216, USA

    Roger H. Unger

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  1. Center for Endocrinology, Metabolism, and Nutrition, Northwestern University Medical School, Chicago, Illinois, USA

    Norbert Freinkel M. D. (Kettering Professor of Medicine, Professor of Biochemistry, Director) (Kettering Professor of Medicine, Professor of Biochemistry, Director)

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Unger, R.H. (1976). Glucagon. In: Freinkel, N. (eds) The Year in Metabolism 1975–1976. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7656-9_3

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