Abstract
Traditionally, studies of the biological effects of ionizing radiation have rested on the triumvirate: (gas-phase) radiation physics, biophysical modeling, and radiation biology. Two technical developments, the advent of supercomputing as a routine tool in quantum solid-state material science and molecular dynamics on the one hand, and molecular biology on the other hand, have created—perhaps for the first time—the possibility of directly linking a more realistic description of the radiation field to observable events at biomolecular level. It also becomes increasingly clear that the identification of specific molecular targets imposes a challenge to the radiation physics community to be equally specific in treating the energy-deposition stage of radiation action. In this paper: a) I review—and exemplify with results from our own work—the current status in Monte Carlo simulation of gas-phase material (particle transport and stochastic chemistry); b) examine the link between these essentially geometric representations of the track and the concept of “spatial distribution of energy deposition,” a staple in radiation modeling; c) advocate an effort towards developing conceptually and calculationally, the field of solid-state microdosimetry; and d) describe methods based on semi-empirical Hamiltonians or quasi-particle techniques for obtaining the frequency-dependent and wave-vector-dependent dielectric response function for biomolecular crystalline systems, which are the main ingredients for describing charged-particle transport.
“Composed out of scattered fragments and snatches of movements.” (Epigraph set by Beethoven on one of the copies of his 14th quartet)
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Zaider, M. (1991). Charged-Particle Transport in the Condensed Phase. In: Glass, W.A., Varma, M.N. (eds) Physical and Chemical Mechanisms in Molecular Radiation Biology. Basic Life Sciences, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7627-9_5
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DOI: https://doi.org/10.1007/978-1-4684-7627-9_5
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