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Synapsin I, A Phosphoprotein Associated with Synaptic Vesicles: Possible Role in Regulation of Neurotransmitter Release

  • Chapter
Molecular Mechanisms of Neuronal Responsiveness

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 221))

Abstract

Elucidation of the molecular events underlying communication between neurons is one of the most exciting problems in neuroscience. While it has been known for many years that the depolarization-dependent influx of calcium into the presynaptic terminal leads to the release of neurotransmitters, little is known about the molecular events which underly this presynaptic process. Similarly, although neurotransmitters are known to produce graded responses via interaction with specific receptors, little is known about the molecular events which underlie these postsynaptic responses. Although it has been generally assumed that protein molecules play important roles in the production of these responses, it is only within the last 15 years that we have come to understand how the activity of proteins could be regulated with a time course consistent with mediation or modulation of neuronal communication. What has become apparent during this period is that protein phosphorylation is a primary mechanism utilized by eukaryotic cells for post-translational regulation of protein function. Consequently, protein phosphorylation represents a conceptual framework for analysis of the molecular mechanisms which underly neuronal communcation. The scheme shown in Figure 1 summarizes our current concepts about the molecular pathways underlying biological regulation of neuronal communication.

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Authors and Affiliations

  1. The Rockefeller University, 1230 York Avenue, New York, NY, 10021, USA

    Paul Greengard, Michael D. Browning & Teresa L. McGuinness

  2. Department of Physiology and Biophysics, New York University Medical Center, New York, NY, 10016, USA

    Rodolfo Llinas

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  1. Paul Greengard
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  2. Michael D. Browning
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  3. Teresa L. McGuinness
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  1. The University of Vermont College of Medicine, Burlington, Vermont, USA

    Yigal H. Ehrlich , Robert H. Lenox  & Elizabeth Kornecki ,  & 

  2. Bolling A.F. Base, U.S. Air Force Office of Scientific Research, Washington, D.C., USA

    William O. Berry

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Greengard, P., Browning, M.D., McGuinness, T.L., Llinas, R. (1987). Synapsin I, A Phosphoprotein Associated with Synaptic Vesicles: Possible Role in Regulation of Neurotransmitter Release. In: Ehrlich, Y.H., Lenox, R.H., Kornecki, E., Berry, W.O. (eds) Molecular Mechanisms of Neuronal Responsiveness. Advances in Experimental Medicine and Biology, vol 221. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7618-7_11

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  • DOI: https://doi.org/10.1007/978-1-4684-7618-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7620-0

  • Online ISBN: 978-1-4684-7618-7

  • eBook Packages: Springer Book Archive

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