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Mechanisms of Hyperlipoproteinemia

  • Chapter
Pharmacological Control of Lipid Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 26))

Abstract

Our understanding of the pathogenesis of hyperlipoproteinemia stems from knowledge of the synthesis, secretion and metabolism of plasma lipoproteins and the regulation of These processes. Application of this knowledge in recent years has provided an explanation of several secondary hyperlipoproteinemias in terms of altered regulation of fat transport. This paper will review current knowledge of fat transport in lipoproteins and the increasing evidence that all major lipoprotein classes are involved in this process. The pathogenesis of certain secondary hyperlipoproteinemias will be discussed in the context of this review. Finally, a speculative assessment of the pathogenesis of the primary hyperlipoproteinemias will be attempted with particular reference to possible mechanisms of defective catabolism.

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Author information

Authors and Affiliations

  1. Cardiovascular Research Institute and Department of Medicine, University of California School of Medicine, San Francisco, California, USA

    Richard J. Havel M.D.

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  1. Richard J. Havel M.D.
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Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti (Director) (Director)

  3. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    David Kritchevsky (Member) (Member)

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© 1972 Springer Science+Business Media New York

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Havel, R.J. (1972). Mechanisms of Hyperlipoproteinemia. In: Holmes, W.L., Paoletti, R., Kritchevsky, D. (eds) Pharmacological Control of Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7547-0_4

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  • DOI: https://doi.org/10.1007/978-1-4684-7547-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7549-4

  • Online ISBN: 978-1-4684-7547-0

  • eBook Packages: Springer Book Archive

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