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Effects of Drugs on the Metabolism of Bile Acids

  • Chapter
Pharmacological Control of Lipid Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 26))

Abstract

Bile acids are the main end products of the breakdown of cholesterol and their metabolism is intimately linked with that of cholesterol. Hence, the study of the effects of drugs on bile acid metabolism, apart from its intrinsic interest, is relevant to the problem of hypercholesterolaemia. Drugs that modify bile acid metabolism may also be used to produce experimental situations that provide information as to how sterol. metabolism is regulated. In this review I shall describe briefly those steps in the synthesis and subsequent fate of bile acids that are likely to be susceptible to the actions of drugs and I shall then discuss the effects of various agents, including hormones and certain dietary factors, that are known to influence bile acid metabolism.

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Author information

Authors and Affiliations

  1. Medical Research Council Lipid Metabolism Unit, Hammersmith Hospital, London, W12 OHS, UK

    N. B. Myant

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  1. N. B. Myant
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Editor information

Editors and Affiliations

  1. Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania, USA

    William L. Holmes (Director) (Director)

  2. Institute of Pharmacology and Pharmacognosy, University of Milan, Milan, Italy

    Rodolfo Paoletti (Director) (Director)

  3. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA

    David Kritchevsky (Member) (Member)

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Myant, N.B. (1972). Effects of Drugs on the Metabolism of Bile Acids. In: Holmes, W.L., Paoletti, R., Kritchevsky, D. (eds) Pharmacological Control of Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7547-0_12

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  • DOI: https://doi.org/10.1007/978-1-4684-7547-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7549-4

  • Online ISBN: 978-1-4684-7547-0

  • eBook Packages: Springer Book Archive

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