Abstract
The introduction of ethanol into a biological system affects its functions in two ways: the first is the effect of ethanol on excitable membranes and the second is the effect of ethanol metabolism on the intermediary metabolism of the system. Both of these primary effects are described in other chapters of this book.
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References
Robison, G.A., Butcher, R.W. and Sutherland, E.W.: Cyclic AMP. Academic Press, New York and London, 1971.
Perkins, J.P.: Adenyl cyclase. Adv. Cyclic Nucleot. Res., 3: 1–65, 1973.
Gorman, R.E. and Bitensky, M.W.: Selective activation by short chain alcohols of glucagon responsive adenyl cyclase in liver. Endocrinol., 87: 1075–1081, 1970.
Greene, H.L., Herman, R.H. and Kraemer, S.: Stimulation of jejunal adenyl cyclase by ethanol. J. Lab. Clin. Med., 78: 336–342, 1971.
Kuriyama, K. and Israel, M.A.: Effect of ethanol administration on cyclic 3’, 5’-adenosine monophosphate metabolism in brain. Biochem. Pharmacol., 22: 2919–2922, 1973.
Mashiter, K., Mashiter, G.D. and Field, J.B.: Effects of prostaglandin E, ethanol and TSH on the adenylate cyclase activity of beef thyroid plasma membranes and cyclic AMP content of dog thyroid slices. Endocrinology, 94: 370–376, 1974.
Volicer, L. and Hynie, S.: Effects of catecholamines and angiotensin on cyclic AMP in rat aorta and tail artery. Eur. J. Pharmacol., 15: 214–220, 1971.
Tague, L.L. and Shanbour, L.L.: Alterations of gastric mucosal cAMP system in presence of ethanol. Tex. Rep. Biol. Med., 31: 103–104, 1973.
Satoh, K. and Ryan, K.J.: Adenyl cyclase in the human placenta. Biochim. Biophys. Acta, 244: 618–624, 1971.
Keirns, J.J. Carritt, B., Freeman, J., Eisenstadt, J.M. and Bitensky, M.W.: Adenosine 3’,5’ cyclic monophosphate in Euglena gracilis. Life Sci, 13: 287–302, 1973.
Kreiner, P.W., Keirns, J.J. and Bitensky, M.W.: A temperature-sensitive change in the energy of activation of hormone-stimulated hepatic adenyl cyclase. Proc. Nat. Acad. Sci. USA, 70: 1785–1789, 1973.
Krishna, G., Weiss, B. and Brodie, B.B.: A simple, sensitive method for the assay of adenyl cyclase. J. Pharmacol. Exp. Ther., 163: 379–385, 1968.
Petrack, B., Ma, D. and Sheppy, F.: Evidence for the formation of apparently new nucleotides by adipocyte ghosts. Fed. Proc.,32: 536, Abs., 1973.
Butcher, R.W. and Sutherland, E.W.: Adenosine 3’,5’-phosphate in biological materials. I. Purification and properties of cyclic 3’,5’-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3’,5’-phosphate in human urine. J. BioZ. Chem., 237: 1244–1250, 1962.
Thompson, W.J. and Appleman, M.M.: Characterization of cyclic nucleotide phophodiesterases of rat tissues. J. Biol. Chem., 246: 3145–3150, 1971.
Cambell, M.T. and Oliver, I.V.: 3’,5’-cyclic nucleotide phosphodiesterases in rat tissues. Eur. J. Biochem., 28: 30–37, 1972.
Appleman, M.M., Thompson, W.J. and Russell, T.R.: Cyclic nucleotide phosphodiesterases. In: Adv. Cyclic Nucleot. Res. 3, P. Greengard and G.A. Robison (eds.) Raven Press, New York, 65–98, 1973.
Brooker, G., Thomas, L.J. Jr. and Appleman, M.M.: The assay of adenosine 3’,5’-cyclic monophosphate and guanosine 3’,5’-cyclic monophosphate in biological materials by enzymatic radioisotope displacement. Biochemistry, 7: 4177–4181, 1968.
Huang, Y.C. and Kemp, R.G.: Properties of a phosphodiesterase with high affinity for adenosine 3’,5’-cyclic phosphate. Biochemistry, 10: 2278–2283, 1971.
Hitchcock, M.: Adenosine 3’,5’-cyclic monophosphate phosphodiesterase in guinea pig lung–properties and effect of adrenergic drugs. Biochem. Pharmacol., 22: 959–969, 1973.
Uzunov, P. and Weiss, B.: Separation of multiple molecular forms of cyclic adenosine 3’,5’-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis. Biochim. Biophys. Acta, 284: 220–226, 1972.
De Robertis, E., Rodriguez, G., Arnaiz, De Lores and Alberici, M.: Subcellular distribution of adenyl cyclase and cyclic phosphodiesterase in rat brain cortex. J. Biol. Chem., 242: 34873493, 1967.
Beavo, J.A., Hardman, J.G. and Sutherland, E.W.: Hydrolysis of cyclic guanosine and adenosine 3’,5’-monophosphates by rat and bovine tissues. J. Biol. Chem., 245: 5649–5655, 1970.
Chasin, M., Harris, D.N., Phillips, M.B. and Hess, S.M.: 1-ethyl-4-(isoprophylidenehydrazino)-1H-pyrazolo-(3,4,b)-pyri-dine-5-carboxylic acid, ethyl ester, hydrochloride (S020009)-a potent new inhibitor of cyclic 3’,5’-nucleotide phosphodiesterases. Biochem. Pharmacol., 21: 2443–2450, 1972.
Cheung, W.Y.: Cyclic 3’,5’-nucleotide phosphodiesterase. Evidence for and properties of a protein activator. J. Biol. Chem., 246: 2859–2869, 1971.
Weiss, B.: Selective regulation of the multiple forms of cyclic nucleotide phosphodiesterase by norepinephrine and other agents. In: Frontiers in Catecholamine Research. E. Usdin and S. Snyder (eds.) pp. 327–333, Pergamon Press, Oxford, 1973.
Tague, L.L. and Shanbour, L.L.: Effects of ethanol on gastric mucosal adenosine 3’,5’-monophosphate (cAMP). Life Sci., 14: 1065–1073, 1974.
Mozsik, G.: Some feed-back mechanisms by drugs in the interrelationship between the active transport system and adenyl cyclase system localized in the cell membrane. Europ. J. Pharmacol., 7: 319–327, 1969.
Luly, P., Barnabei, O. and Tria, E.: Hormonal control in vitro of plasma membrane-bound (Na+-K+)-ATPase of rat liver. Biochim. Biophys. Acta, 282: 447–452, 1972.
Dousa, T.: Adenosine 3’,5’-cyclophosphate and (Na+-K4) activated adenosine triphosphatase. Physiol. Bohemoslov., 19: 113–115, 1970.
Lenaz, G., Parenti-Castelli, G., Monsigni, N. and Silvestrini, M.G.: Effect of alcohols on the functional organization of the inner mitochondrial membrane. Bioenergetics, 2: 119127, 1971.
Grisham, C.M. and Barnett, R.E.: The effects of long chain alcohols on membrane lipids and the (Na+-K+)-ATPase. Biochim. Biophys. Acta, 311: 417–422, 1973.
Järnefelt, J.: Lipid requirements of functional membrane structures as indicated by the reversible inactivation of (Na+-K+)-ATPase. Biochim. Biophys. Acta, 266: 91–96, 1972.
Israel, Y., Kalant, H., Le Blanc, E., Bernstein, J. and Salazar, I.: Changes in cation transport and (Na+-K+)-activated adenosine triphosphatase produced by chronic administration of ethanol. J. Pharmacol. Exp. Ther., 174: 330–336, 1970.
Sun, A.Y. and Samorajski, T.: Effects of ethanol on the activity of adenosine triphosphatase and acetylcholinesterase in synaptosomes isolated from guinea-pig brain. J. Neurochem., 17: 1365.. 1372, 1972.
Israel, Y. and Salazar, I.: Inhibition of brain microsomal adenosine triphosphatases by general depressants. Arch. Biochem. and Biophys., 122: 310–317, 1967.
Roach, M.K., Khan, M.M., Coffman, R., Pennington, W. and Davis, D.L.: Brain (Ne-e)) activated adenosine triphosphatase activity and neurotransmitter uptake in alcohol-dependent rats. Brain Res, 63: 323–329, 1973.
Knox, W.H., Perrin, R.G. and Sen, A.K.: Effect of chronic administration of ethanol on (Na+-K+)-activated ATPase activity in six areas of the cat brain. J. Neurochem., 19: 2881–2884, 1972.
Akera, T., Rech, R.H., Marquis, W.J., Tobin, T. and Brody, T.M.: Lack of relationship between brain (Na+-K+)-activated adenosine triphosphatase and the development of tolerance to ethanol in rats. J. Pharmacol. Exp. Ther., 185: 594–601, 1973.
Israel, Y., Carmichael, F.J. and Macdonald, J.A.: Effects of ethanol on norepinephrine uptake and electrically stimulated release in brain tissue. Ann. N.Y. Acad. Sci., 215: 38–48, 1973.
Goldstein, D.B. and Israel, Y.: Effects of ethanol on mouse brain (Na -K)-activated adenosine triphosphatase. Life Sci. (II), 11: 957–963, 1972.
Israel, M.A. and Kuriyama, K.: Effect of in vivo ethanol administration on adenosinetriphosphatase activity of subcellular fraction of mouse brain and liver. Life Sci. (II), 10: 591–599, 1971.
Rawat, A.K., Kuriyama, K. and Mose, J.: Metabolic consequences of ethanol oxidation in brains from mice chronically fed ethanol. J. Neurochem., 20: 23–33, 1973.
Hyams, D.E. and Isselbacher, K.J.: Prevention of fatty liver by administration of adenosine triphosphate. Nature, 204: 1196–1197, 1964.
French, S.W.: Effect of acute and chronic ethanol ingestion on rat liver ATP. Proc. Soc. Exp. BioZ. Med., 121: 68 1685, 1966.
Oura, E., Räihä, N.C.R. and Suomalainen, H.: Influence of some alcohols and narcotics on the adenosine phosphates in the liver of the mouse. Ann. Biol. Exptl. Med. Fenn., 45: 57–62, 1966.
Ammon, H.P.T. and Estler, C.J.: Influence of acute and chronic administration of alcohol on carbohydrate breakdown and energy metabolism in the liver. Nature, 216: 158–159, 1967.
Walker, J.E.C. and Gordon, E.R.: Biochemical aspects associated with an ethanol-induced fatty liver. Biochem. J., 119: 51 1516, 1970.
Marchetti, M., Ottani, V., Zanetti, P. and Puddu, P.: Aspects of lipid metabolism in ethanol-induced fatty liver. J. Nutr., 95: 607–611, 1968.
Gordon, E.R. and Lough, J.: Ultrastructural and biochemical aspects during the regression of an ethanol-induced fatty liver. Lab. Invest., 26: 154–162, 1972.
Grunnet, N. and Thieden, H.J.D.: The effect of ethanol concentration upon in vivo metabolite levels of rat liver. Life Sci. (II), 11: 983–993, 1972.
Veech, R.L., Guynn, R. and Veloso, D.: The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver. Biochem. J., 127: 387–397, 1972.
Higgins, E.S. and Banks, W.L.: Cognate effects of ethanol, hydrazine and tissue regeneration on hepatic mitochondrial activities. Biochem. Pharmacol., 20: 1513–1524, 1971.
Gajdos, A. and Gajdos-TÖrök, M.: Study of the effect of exogenous glucose on the excess formation of porphyrins and NADH in the liver of rats intoxicated with ethanol. Biochim. Biophys. Acta, 215: 550–553, 1970.
Griffaton, G., Baron, P. and Lowy, R.: Effets d’une administration aiguë d’ethanol et de fructose sur les teneurs en nucleotides adenyliques du foie de rat. Arch. Int. PhysioZ. Biochim., 79: 75–85, 1971.
Pachinger, 0.M., Tillmanns, H., Mao, J.C., Fauvel, J.M. and Bing, R.J.: The effect of prolonged administration of ethanol on cardiac metabolism and performance in the dog. J. Clin. Invest., 52: 2690–2696, 1973.
Carter, E.A. and Issellbacher, K.J.: Effect of ethanol on intestinal adenosine triphosphate content. Proc. Soc. Exp. Biol. Med., 142: 1171–1173, 1973.
Tague, L.L. and Shanbour, L.L.: Effects of ethanol on possible transport mechanisms of the gastric mucosa. Gastroenterology, 66: 787, Abs., 1974.
Pliska, V., Glattfelder, A. and Birnbaumer, L.: Regulation of cAMP action on the cellular level: a compartment model. Experientia, 28: 750, 1972.
Tague, L.L. and Shanbour, L.: Effects of ethanol on Mg++ and Mg++, HCO3-stimulated ATPase, ATP and cyclic 3’,5’-adenosine monophosphate in canine gastric mucosa. J. Pharmaeol. Exp. Ther.,(In Press).
Solomon, N., Solomon, T.E., Jacobson, E.D. and Shanbour, L.L.: Direct effects of alcohol on in vivo and in vitro exocrine pancreatic secretion and metabolism. Am. J. Dig. Dis., 19: 253–260, 1974.
Sherr, H., Herman, R.H., Stifel, F.B. and Hagler, L.: Personal Communication.
Volicer, L.: Effect of ethanol on adenosine 3’,5’-monophosphate in rat tissues in vivo. Pharmacologist, 13: 218, 1971.
Stifel, F.B., Greene, H.L., Lufkin, E.G. and Herman, R.H.: Acute effects of oral and intravenous ethanol on rat hepatic enzyme activities. Fed. Proc., 33: 709, 1974.
Volicer, L. and Gold, B.I.: Effect of ethanol on cyclic AMP levels in the rat brain. Life Sci., 13: 269–280, 1973.
Sattin, A.: Increase in the content of adenosine 3’,5’-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines. J. Neurochem., 18: 1087–1096, 1971.
Paul, M.J., Pauk, G.L. and Ditzion, B.R.: The effect of centrally acting drugs on the concentration of brain adenosine 3’,5’-monophosphate. Pharmacology, 3: 148–154, 1970.
Israel, M.A., Kimura, H. and Kuriyama, K.: Changes in activity and hormonal sensitivity of brain adenyl cyclase following chronic ethanol administration. Experientia, 28: 1322 1323, 1972.
Katz, L. and Tenenhouse, A.: The relation of adenyl cyclase to the activity of other ATP utilizing enzymes and phosphodiesterase in preparations of rat brain; mechanism of stimulation of cyclic AMP accumulation by NaF. Br. J. Pharmaeol., 48: 505–515, 1973.
French, G.W. and Palmer, D.S.: Adrenergic supersensitivity during ethanol withdrawal in the rat. Res. Commun. Chem. PathoZ. Pharmacol., 6: 651–662, 1973.
Palmer, D.S., French, G.W. and Narad, M.E.: Increase in cAMP response to norepinephrine, histamine and serotonin by brain slices in ethanol dependent rats. Fed. Proc., 33: 710, 1974.
French, G.W., Palmer, D.S. and Narad, M.: Increase in cyclic AMP response to norepinephrine by liver mitochondria in ethanol-dependent rats. Am. J. PathoZ., 74: 67a, 1974.
Majchrowicz, E.: Effects of ethanol on liver metabolism. Adv. Exp. Med. Biol., 35: 79–104, 1973.
Mallow, G. and Bloch, J.L.: Role of hypophysis and adrenals in fatty infiltration of liver resulting from acute ethanol intoxication. Am. J. PhysioZ., 184: 29–34, 1956.
Maickel, R.P. and Brodie, B.B.: Interaction of drugs with the pituitary-adrenocortical system in the production of the fatty liver. Ann. N.Y. Acad. Sci., 104: 1059–1064, 1963.
Brodie, B.B. and Maickel, R.P.: Role of the sympathetic nervous system in drug-induced fatty liver. Ann. N.Y. Acad. Sci., 104: 1049–1058, 1963.
Claycomb, W.C. and Kilsheimer, G.S.: Effect of glucagon, adenosine-3’,5’-monophosphate and theophylline on free fatty acid release by rat liver slices and on tissue levels of coenzyme A esters. Endocrinology, 84: 1179, 1969.
Schapiro, R.H., Drummey, G.D., Yoshitaka, S. and Isselbacher, K.J.: Studies on the pathogenesis of the ethanol-induced fatty liver. II. Effect of ethanol on palmitate-1-C14 metabolism by the isolated perfused rat liver. J. Clin. Invest., 43: 1338–1347, 1964.
Heimberg, M., Weinstein, I. and Kohant, M.: The effects of glucagon, dibutyryl cyclic adenosine 3’,5’-monophosphate and concentration of free fatty acid on hepatic lipid metabolism. J. Biol. Chem., 244: 5131–5139, 1969.
Erwin, V.G., Anderson, A.D. and Eide, G.J.: Enhancement of fatty acid oxidation and medium-chain fatty acyl coenzyme A synthetase by adenine nucleotides in rat heart homogenates. J. Pharm. Sci., 60: 77–80, 1971.
Poggi, M. and DiLuzio, N.R.: The role of liver and adipose tissue in the pathogenesis of the ethanol-induced fatty liver. J. Lipid Res., 5: 437–441, 1964.
Reboucas, G. and Isselbacher, K.J.: Studies on the pathogenesis of the ethanol-induced fatty liver: I. Synthesis and oxidation of fatty acids by the liver. J. Clin. Invest., 40: 1355–1362, 1961.
Fex, G. and Olivecrona, T.: Role of uptake and oxidation of plasma free fatty acids by the liver in the development of the ethanol-induced fatty liver. Acta Physiol. Scand., 75: 78–81, 1969.
Kakiuchi, S. and Rall, T.W.: The influence of chemical agents on the accumulation of adenosine 3’,5’-phosphate in slices of rabbit cerebellum. Mol. Pharmacol., 4: 367–378, 1968.
Kebabian, J.W., Petzold, G.L. and Greengard, P.: Dopamine-sensitive asenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”. Proc. Nat. Acad. Sci. USA., 69: 2145–2149, 1972.
Chou, W.S., Ho, A.K.G. and Lo, H.H.: Effect of acute and chronic morphine and norepinephrine on brain adenyl cyclase activity. Proc. West. Pharmacol. Soc., 14: 42–46, 1971.
Burkard, W.P.: Catecholamine induced increase of cyclic adenosine 3’,5’-monophosphate in rat brain in vivo. J. Neurochem., 19: 2615–2619, 1972.
Bloom, F.W., Hoffer, B.J., Battenberg, E.R., Siggins, G.R., Steiner, A.L., Parker, C.W. and Wedner, H.J.: Adenosine 3’,5’-monophosphate is localized in cerebellar neurons: Immunofluorescence evidence. Science, 177: 436–438, 1972.
Ungerstedt, U.: Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol. Scand., (Suppl.) 367, 1971.
Bloom, F.E., Hoffer, B.J. and Siggins, G.R.: Norepinephrine mediated cerebellar synapses: A model system for neuropsychopharmacology. BioZ. Psychiatry, 4: 157–177, 1972.
Siggins, G.R., Oliver, A.P., Hoffer, B.J. and Bloom, F.E.: Cyclic adenosine monophosphate and norepinephrine: Effects on transmembrane properties of cerebellar Purkinje cells. Science, 171: 192–194, 1971.
Godfraind, J.M. and Pumain, R.: Cyclic adenosine monophosphate and norepinephrine: Effect on Purkinje cells in rat cerebellar cortex. Science, 174: 1257–1258, 1971.
Lake, N. and Jordan, L.M.: Failure to confirm cyclic AMP as second messenger for norepinephrine in rat cerebellum. Science, 183: 663–664, 1974.
Greengard, P., McAfee, D.A. and Kebabian, J.W.: On the mecha-nism of action of cyclic AMP and its role in synaptic transmission. Adv. Cyclic Nucleot. Res., 1: 337–355, 1972.
McAfee, D.A. and Greengard, P.: Adenosine 3’,5’-monophosphate: Electrophysiological evidence for a role in synaptic transmission. Science, 178: 310–312, 1972.
DiPerri, R., Dravid, A., Schweigerdt, A. and Himwich, H.E.: Effects of alcohol on evoked potentials of various parts of the central nervous system of cat. Quart. J. Stud. Ale., 29: 20–37, 1968.
Allsop, J. and Turner, B.: Cerebellar degeneration associated with chronic alcoholism. J. Neurol. Sci., 3: 238–258, 1966.
Eidelberg, E., Bond, M.L. and Kelter, A.: Effects of alcohol on cerebellar and vestibular neurones. Arch. Int. Pharmacodyn. Ther., 192: 213–219, 1971.
Blum, K.: Effects of catecholamine synthesis inhibition on ethanol narcosis in mice. Curr. Ther. Res., 14: 324–329, 1972.
Smith, A.A., Hayashida, K. and Kim, Y.: Inhibition by propranolol of ethanol-induced narcosis. J. Pharm. Pharmacol., 22: 644–645, 1970.
Hayashida, K. and Smith, A.A.: Reversal by sotalol of the respiratory depression induced in mice by ethanol. J. Pharm. Pharmacol., 23: 718–719, 1971.
Allen, L.E., Ferguson, H.C. and McKinney, G.R.: A survey of selected drugs on behavior performance in ethanol-treated rats. Eur. J. Pharmacol., 15: 371–374, 1971.
Hungen, K.V. and Roberts, S.: Adenylate cyclase receptors for adrenergic transmitters in rat cerebral cortex. Eur. J. Biochem., 36: 391–401, 1973.
Stone, C.A. and Porter, C.C.: Biochemistry and pharmacology of methyldopa and some related structures. Adv. Drug. Res., 4: 71–93, 1967.
Goldman, V., Comerford, B., Hughes, D. and Nyberg, G.: Effect of 13-adrenergic blockade and alcohol on simulated car driving. Nature, 224: 1175–1178, 1969.
Mendelson, J.H., Rossi, A.M., Bernstein, J.G. and Kuehnle, J.: Effects of propranolol on behavior of alcohol addicts following acute ethanol intake. (submitted for publication).
Noble, E.P., Parker, E., Alkana, R., Cohen, H. and Birch, H.: Propranolol-ethanol interaction in man. Fed. Proc., 32: 724, Abs., 1973.
Cohn, M.L., Kraynack, B., Cohn, M. and Scattaregia, F.: Interaction of cyclic AMP with neuropharmacologic depressant agents. Fed. Proc., 32: 680, Abs., 1973.
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Volicer, L., Gold, B.I. (1975). Interactions of Ethanol with Cyclic AMP. In: Majchrowicz, E. (eds) Biochemical Pharmacology of Ethanol. Advances in Experimental Medicine and Biology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7529-6_10
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