Abstract
The most common reactions at the A-ring of proanthocyanidins (condensed tannins) are examples of electrophilic aromatic substitution where an electrophile displaces a hydrogen (i.e., at C-6 and/or C-8 of procyanidins and profisetinidins). Other types of displacements include dehalogenation, procyanidin degradation, and oxidative free-radical coupling. The hydroxylation pattern of the A-ring controls both reactivity and orientation of substitution, partially by steric effects, but electronic factors have more influence. Examples of A-ring reactions include those of commercial interest (methylolation, condensation) and of diagnostic interest (halogenation, alkylation, hydrogen/deuterium exchange). C- and O-glycosylation are further types of A-ring reactions leading to natural products.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Roux, D.G.; Ferreira, D. The direct biomimetic synthesis, structure and absolute configuration of angular and condensed tannins. Fortschr. Chem. Org . Naturst. 41: 47 (1982).
McGraw, G. W.; Hemingway, R.W. Electrophilic aromatic substitution of catechin: Bromination and benzylation. J. Chem. Soc. Perkin Trans. 1:974 (1982).
Kiatgrajai, P.; Wellons, J.D.; L. Gollob, L.; White, J.D. Kinetics of polymerizaiton of (+)-catechin with formaldehyde. J. Org . Chem. 47: 2913 (1982).
Haslam, E. Biogenetically patterned synthesis of procyanidins. J. Chem. Soc. Chem. Commun.: 594 (1974).
Botha, J.J.; Viviers, P.M.; Ferreira, D.; Roux, D.G. Condensed tannins: Competing nudeophilic centres in biomimetic condensation reactions. Phytochemistry 21: 1289 (1982).
McGraw, G.W.; Hemingway, R.W.; Ohara, S. Reactions of tannin model compounds with methylolphenols. In: Hemingway, R.W.; Conner, A.H.; Branham, S.J. (eds.) Adhesives from Renewable Resources. Symposium Series No. 385, Amercian Chemical Society, Washington, DC. pp. 185–202 (1989).
Weinges, K.; Perner, J.; Marx, H.-D. Synthese des octamethyl-diacetyl-procyanidins B3, Chem. Ber. 103: 2344 (1970).
Engel, D.W.; Hattingh, M.; Hundt, H.K.L.; Roux, D.G. X-ray structure, conformation, and absolute configuration of 8-bromotetra-O-methyl-(+)-catechin. J. Chem. Soc. Chem. Commun.: 695 (1978).
Kiehlmann, E.; Lehto, N.; Cherniwchan, D. Iodination and deuteration of catechin derivatives. Can. J. Chem. 66: 2431 (1988).
Fronczek, F.R.; Gannuch, G.; Mattice, W.L.; Hemingway, R.W.; Chiari, G.; Tobiason, F.L.; Houglum, K.; Shannafelt, A. Preference for occupancy of axial positions by substitutents bonded to the heterocydic ring in penta-0-acetyl-(+)-catchin in the crystalline state. J. Chem. Soc. Perkin Trans. 2: 1383 (1985).
Hundt, H.K.L.; Roux, D.G. Condensed tannins: Determination of the point of linkage in `terminal’ (+)-catechin units and degradative bromination of 4-flavanylflavan-3,4-diols. J. Chem. Soc. Chem. Commun.: 696 (1978).
Nonaka, G.; Morimoto, S.; Nishioka, I. Tannins and related compounds. Part 13. Isolation and structures of trimeric, tetrameric, and pentameric proanthocyanidins from cinnamon. J. Chem. Soc. Perkin Trans. 1:2139 (1983).
Young, D.A.; Cronje, A.; Bates, A.L.; Ferreira, D.; Roux, D.G. Synthesis of condensed tannins. Part 14. Biflavanoid profisetinidins as synthons. The acid-induced `phlobaphene’ reaction. J. Chem. Soc. Perkin Trans. 1: 2521 (1985).
Herrick, F.W.; Bock, L.J. Adhesives from bark extracts. For. Prod. J. 8: 269 (1958).
Hillis, W.E.; Urbach, G. Reactions of polyphenols with formaldehyde. J. Appl. Chem. 9: 665 (1959).
Roux, D.G.; Ferreira, D.; Hundt, H.K.L.; Malan, E. Structure, stereochemistry, and reactivity of natural condensed tannins as basis for their extended industrial applicaiton. In: Timell, T.E. (ed.) Proc. of the Eighth Cellulose Conf. Appl. Polym. Symp. No. 28. John Wiley and Sons, New York (1975).
Pizzi, A.; Scharfetter, H.O. The chemistry and development of tannin-based adhesives for exterior plywood. J. Appl. Polym. Sci. 22: 1745 (1978).
Plomley, K.F. Tannin-formaldehyde adhesives for wood. CSIRO, Div. For. Prod. Technol. Paper No. 39 (1966).
Porter L.J. Viscosity and formaldehyde consumption of procyanidin solutions. In: Hemingway, R.W.; Conner, A.H.; Branham, S.J. (eds.) Adhesives from Renewable Resources. Symposium Series, No. 385, American Chemical Society, Washington, DC. pp. 172–184 (1989).
Hemingway, R.W.; McGraw, G.W. Formaldehyde condensation products of model phenols for conifer bark tannins. J. Liq. Chromatog. 1: 163 (1978).
Hillis, W.E.; Urbach, G. The reaction of (+)-catechin with formaldehyde. J. Appl. Chem. 9: 474 (1959).
Ayla, C. Pines brutia tannin adhesives. J. Appl. Polym. Sci., Appl. Polym. Symp. 40: 69 (1984).
Pizzi, A. Tannin-based wood adhesives. In: Pizzi, A. (ed.) Wood Adhesives: Chemistry and Technology. Marcel Dekker, Inc., New York, pp. 177–246 (1983).
Rossouw, D. du T.; Pizzi, A.; McGillvray, G. The kinetics of condensation of phenolic polyflavonoid tannins with aldehydes. J. Polym. Sci. Polym. Chem. Ed. 18: 3323 (1980).
Foo, L.Y.; Hemingway, R.W. Condensed tannins: reactions of model compounds with furfuryl alcohol and furfuraldehyde. J. Wood Chem. Technl. 5: 135 (1985).
Pizzi, A.; Rossouw, D.du T.; Daling, G.M.E. The role of aldehydes other than HCHO in tannin-based wood adhesives. Holzforsch. Holzverwert 32: 101 (1980).
MacLean, H.; Gardner, J.A.F. Bark extracts in adhesives. Pulp Paper Mag. Can. 53: 111 (1952).
Scharfetter, H.; Pizzi, A.; Roussouw, D.du T. IUFRO Conference on Wood Gluing, Merida, Venezuela, Oct. (1977).
Herrick, F.W.; Conca, R.J. The use of bark extracts in coldsetting waterproof adhesives. For. Prod. J. 10: 361 (1960).
Hemingway, R.W.; McGraw, G.W.; Karchesy, J.J. Condensation of hydroxybenzyl alcohols with catechin: a model for methylolphenols in conifer-bark polyflavonoid adhesives. In: Phenolic Resins, Chemistry and Applications. Weyerhaeuser Science Symposium 2, Weyerhaeuser Co., Tacoma, Washington, pp. 33–67 (1981).
Botha, J.J.; Ferreira, D.; Roux, D.G. Synthesis of condensed tannins. Part 4. A direct biomimetic approach to [4,6]- and [4,8]-biflavanoids. J. Chem. Soc. Perkin Trans. 1: 1235 (1981).
Botha, J.J.; Viviers, P.M.; Young, D.A.; duPreez, I.C.; Ferreira, D.; Roux, D.G.; Hull, W.E. Synthesis of condensed tannins. Part 5. The first angular [4,6;4,8]-triflavanoids and their natural counterparts. J. Chem. Soc. Perkin Trans. 1: 527 (1982).
Viviers, P.M.; Botha, J.J.; Ferreira, D.; Roux, D.G.; Saayman, H.M. Synthesis of condensed tannins. Part 7. Angular [4,6;4,8]-prorobinetindin triflavanoids from black wattle (`mimosa’) bark extract. J. Chem. Soc. Perkin Trans. 1: 17 (1983).
Porter, L.J.; Foo, L.Y. Leucocyanidin: Synthesis and properties of (2R,3S,4R)-(+)-3,4,5,7,3’,4’-hexahydroxyflavan. Phytochemistry 21: 2947 (1982).
Stafford, H.A.; Lester, H.H. Flavan-3-ol biosynthesis: The conversion of (+)-dihydroquercetin and flavan-3,4-cis-diol (leucocyanidin) to (+)-catechin by reductases extracted from cell suspension cultures of Douglas-fir. Plant Physiol. 76: 184 (1984).
Stafford, H.A.; Lester, H.H.; Porter, L.J. Chemical and enzymatic synthesis of monomeric procyanidins (Leucocyanidins or 3’,4’,5,7-tetrahydroxy-flavan-3,4-diols) from (2R,3R)-dihydroquercetin. Phytochemistry 24: 333 (1985).
Kolodziej, H. The first 2,3-trans-3,4-cis-procyanidin. Phytochemistry 24: 2460 (1985).
Delcour, J.A.; Serneels, E.J.; Ferreira, D.; Roux, D.G. Synthesis of condensed tannins. Part 13. The first 2,3-trans-3,4-cis-procyanidins: sequence of units in a `trimer’ of mixed stereochemistry. J. Chem. Soc. Perkin Trans. 1: 669 (1985).
Betts, M.J.; Brown, B.R.; Brown, P.E.; Pike, W.T. Degradation of condensed tannins: structure of the tannin from common heather. J. Chem. Soc. Chem. Commun.: 110 (1967).
Sears, K.D.; Casebier, R.L. Cleavage of proanthocyanidins with thioglycollic acid. J. Chem. Soc. Chem. Commun.: 1437 (1968).
Betts, M.J.; Brown, B.R.; Shaw, M.R. Reaction of flavanoids with mercaptoacetic acid. J. Chem. Soc. (C):1178 (1969).
Sears, K.D.; Casebier, R.L. The reaction of thioglycollic acid with polyflavanoid bark fractions of Tsuga heterophylla. Phytochemistry 9: 1589 (1970).
Thompson, R.S.; Jacques, D.; Haslam, E.; Tanner, R.J.N. Plant proanthocyanidins. Part 1. Introduction; the isolation, structure, and distribution in nature of plant procyanidins. J. Chem. Soc. Perkin Trans. I: 1209 (1982).
Hemingway, R.W.; Foo, L.Y.; Porter, L.J. Linkage isomerism in trimeric and polymeric 2,3-cis-procyanidins. J. Chem. Soc. Perkin Trans. 1: 1209 (1982).
Foo, L.Y.; Porter, L.J. Synthesis and conformation of procyanidin diastereoisomers. J. Chem. Soc. Perkin Trans. 1: 1535 (1983).
Foo, L.Y. Facile self-condensation of melacacidin: a demonstration of the reactivity of the pyrogallol A-ring. J. Chem. Soc. Chem. Commun.: 1273 (1985).
Foo, L.Y. A novel pyrogallol A-ring proanthocyanidin dimer from Acacia melanoxylon. J. Chem. Soc. Chem. Commun.: 236 (1986).
Malan, E.; Roux, D.G. Flavonoids and tannins of Acacia species. Phytochemistry 14: 1835 (1975).
Hemingway, R.W.; Foo, L.Y. Condensed tannins: quinone methide intermediates in procyanidin synthesis. J. Chem. Soc. Chem. Commun.: 1035 (1983).
Foo, L.Y.; Hemingway, R.W. Condensed tannins: synthesis of the first `branched’ procyanidin trimer. J. Chem. Soc. Chem. Commun.: 85 (1984).
Sears, K.D.; Casebier, R.L.; Hergert, H.L.; Stout, G.H.; McCandlish, L.E. The structure of catechinic acid. A base rearrangement product of catechin. J. Org . Chem. 39: 3244 (1975).
Laks, P.E.; Hemingway, R.W.; Conner, A.H. Condensed tannins. Base-catalyzed reactions of polymeric procyanidins with phloroglucinol: intramolecular rearrangements. J. Chem. Soc. Perkin Trans. 1: 1875 (1987).
Laks, P.E.; Hemingway, R.W. Condensed tannins. Structure of the `phenolic acids’. Holzforschung 41: 287 (1987).
Steenkamp, J.A.; Steynberg, J.P.; Brandt, E.V.; Ferreira, D.; Roux, D.G. Phlobatannins, a novel class of ring-isomerized condensed tannins. J. Chem. Soc. Chem. Commun.: 1678 (1985).
Steynberg, J.P.; Young, D.A.; Burger, J.F.W.; Ferreira, D.; Roux, D.G. Phlobatannins via facile ring isomerizations of profisetinidin and prorobinetinidin condensed tannin units. J. Chem. Soc. Chem. Commun.: 1013 (1986).
Furlong, J.J.P.; Nudleman, N.S. Base-catalyzed aromatic hydrogen exchange in phenols. Acta Sud Americana de Quimica 3: 129 (1983).
Weinges, K.; Ebert, W.; Huthwelker, D.; Mattauch, H.; Perner, J. Konstitution und Bildungsmechanismus des Dehydro-dicatechins. Liebigs Ann. Chem. 726: 124 (1969).
Hundt, H.K.L.; Roux, D.G. Synthesis of condensed tannins. Part 3. Chemical shifts for determining the 6- and 8-bonding positions of `terminal’ (+)-catechin units. J. Chem. Soc. Perkin Trans. 1: 1227 (1981).
Kiehlmann, E.; van der Merwe, P.J.; Hundt, H.K.L. Synthesis of 6-bromo-, 8-bromo-, and 6,8-dibromocatechin. Org . Prep. Proc. Int. 15: 341 (1983).
Locksley, H.D. The chemistry of biflavonoid compounds. Fortschr. Chem. Org . Naturstoffe 30: 208 (1973).
Hathway, D.E. The condensed tannins. In: Hillis, W.E. (ed.) Wood Extractives. Academic Press, New York (1962).
Young, D.A.; Young, E.; Roux, D.G.; Brandt, E.V.; Ferreira, D. Synthesis of condensed tannins. Part 19. Phenol oxidative coupling of (+)-catechin and (+)-mesquitol. Conformation of bis-(+)-catechins. J. Chem. Soc. Perkin Trans. I:2345 (1987).
Hathway, D.E.; Seakins, J.W.T. Autoxidation of catechin. Nature 176: 218 (1955).
Brown, B.R.; Whiteoak, R.J. Polymerisation of flavans. Part VII. Oxidative polymerisation of catechin. J. Chem. Soc.: 6084 (1964).
Geismann, T.A.; Crout, D.H.G. Organic Chemistry of Secondary Plant Metabolism. Freeman, Cooper and Co., San Francisco. (1969).
Hathway, D.E. Autoxidation of polyphenols. Part IV. Oxidative degradation of the catechinautoxidation polymer. J. Chem. Soc.: 520 (1958).
Jacobs, E.; Ferreira, D.; Roux, D.G. Atropisomerism in a new class of condensed tannins based on biphenyl and o-terphenyl. Tetrahedron Letters 24: 4627 (1983).
Tonaka, T.; Nonaka, G.; Nishioka, I. 7-O-Galloyl-(+)-catechin and 3-O-galloylprocyanidin B-3 from Sanguisorba officinalis. Phytochemistry 22: 2575 (1983).
Coxon, D.T.; Holmes, A.; 011is, W.D.; Vora, V.C.; Grant, M.S.; Tee, J.L. Flavanol digallates in green tea leaf. Tetrahedron 28: 2819 (1972).
Nonaka, G.; Nishioka, I. Tannins and related compounds. VII. Phenylpropanoid-substituted epicatechins, cinchonains from Cinchona siccirubra. Chem. Pharm. Bull. 30: 4268 (1982).
Nonaka, G.; Kawahara, O.; Nishioka, L Tannins and related compounds. VIII. A new type of proanthocyanidin, cinchonains lla and 11b from Cinchona succirubra. Chem. Pharm. Bull. 30: 4277 (1982).
Hemingway, R.W. Biflavonoids and proanthocyanidins. In:Rowe, J.W. (ed.) Natural Products Extraneous to the Lignocellulosic Cell Wall of Wood Plants. Springer Verlag, New York (in press).
Miyamura, M.; Nohara, T.; Tomimatsu, T.; Nishioka, I. Seven aromatic compounds from the bark of Cinnamomum cassia. Phytochemistry 22: 215 (1983).
Oberholzer, M.E.; Rall, G.J.H.; Roux, D.G. (2R,3S,4S)-3,4,7,3’,4’-Pentamethoxy-2,3-trans3,4-cis-flavan, a novel flavan from Neorautanenia amboensis. Phytochemistry 19: 2503 (1980).
duPreez, I.C.; Roux, D.G. Novel flavan-3,4-diols from Acacia culturiformis. J. Chem. Soc. (C): 1800 (1970).
Nonaka, G.; Ezaki, E.; Hayashi, K.; Nishioka, I. Flavanol glucosides from rhubarb and Raphiolepis imbellata. Phytochemistry 22: 1659 (1983).
Doskotch, R.W.; Mikhail, A.A.; Chatterjii, S.J. Structure of the water-soluble feeding stimulant for Scolytus multistriatus. A revision. Phytochemistry 12: 1153 (1973).
Karl, C.; Muller, G.; Pederson, P.A. Ein neues Catechinglycosid aus Polypodium vulgare. Z. Naturforsch. 37c: 148 (1982).
Kashiwada, Y.; Nonaka, G.; Nishioka, I. Tannins and related compounds. XLV. Rhubarb (5). Isolation and characterization of flavan-3-ol and procyanidin glucosides. Chem. Pharm. Bull. 34: 3208 (1986).
Morimoto, S.; Nonaka, G.; Nishioka, I. Tannins and related compounds. XXXVIII. Isolation and characterization of flavan-3-o1 glucosides and procyanidin oligomers from cassia bark Cinnamomum cassia Blume). Chem. Pharm. Bull. 34: 633 (1986).
Nonaka, G.; Nishioka, I. Novel biflavonoids, chalcan-flavan dimers from Gambir. Chem. Pharm. Bull. 28: 3145 (1980).
Nonaka, G.; Nishimura, H.; Nishioka, I. Tannins and related compounds. Part 26. Isolation and structures of stenophyllanins A, B, and C, novel tannins from Quercus stenophylla. J. Chem. Soc. Perkin Trans. 1: 163 (1985).
Bohlmann, F.; Zdero, C.; King, R.M.; Robinson, H. New prenylflavanoids from Marshal lia grandiflora. Phytochemistry 18: 1246 (1979).
Gomez, F.; Quijano, L.; Calderon, J.S.; Rodriquez, C.; Tios, T. Prenylflavans from Tephrosia watsoniana. Phytochemistry 24: 1057 (1985).
Bohlmann, F.; Jakupovic, J.; King, R.M.; Robinson, H. Chromones and flavans from Marshallia obovata. Phytochemistry 19: 1815 (1980).
Homberger, K.; Hesse, M. Kopsirachin, ein ungewohnliches Alkaloid aus der Apocynacea Kopsia dasyrachis Ridl. Helv. Chim. Acta 67: 237 (1984).
Shen, Z.; Haslam, E.; Falshaw, C.P.; Begley, M.J. Procyanidins and polyphenols of Larix gmelini bark. Phytochemistry 25: 2629 (1986).
Ferreira, D.; duPreez, I.C.; Wijnmaalen, J.C.; Roux, D.G. Biflavanoid proguibourtinidin carboxylic acids and the biflavanoid homologues from Acacia luderitzii. Phytochemistry 24: 2415 (1985).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
McGraw, G.W. (1989). Reactions at the A-ring of Proanthocyanidins. In: Hemingway, R.W., Karchesy, J.J., Branham, S.J. (eds) Chemistry and Significance of Condensed Tannins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7511-1_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7511-1_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7513-5
Online ISBN: 978-1-4684-7511-1
eBook Packages: Springer Book Archive