Skip to main content

Metabolic Activities in the Arterial Wall

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 115))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. Lehninger, A.L. Biochemistry. Worth Publishers, N.Y., 1970.

    Google Scholar 

  2. Scott, R.F., Morrison, E.S. and Kroms, M.: Effect of cold shock on respiration and glycolysis in swine arterial tissue. Am. J. Physiol. 219, 1363–1365, 1970.

    PubMed  CAS  Google Scholar 

  3. Scott, R.F., Morrison, E.S., and Kroms, M.: Aortic respiration and glycolysis in the pre-proliferative phase of diet-induced atherosclerosis in swine. J. Atheroscler. Res. 9, 5–16, 1969.

    Article  PubMed  CAS  Google Scholar 

  4. Morrison, E.S., Scott, R.F., Kroms, M., and Frick, J.: Glucose degradation in normal and atheroslerotic aortic intima-media. Atherosclerosis 16, 175–184, 1972.

    Article  PubMed  CAS  Google Scholar 

  5. Morrison, A.D., Berwick, L., Orci, L., and Winegrad, A.I.: Morphology and metabolism of an aortic intima-media preparation in which an intact endothelium is preserved. J. Clin. Invest. 5, 650–660, 1976.

    Article  Google Scholar 

  6. Arnqvist, H.J. and Lundholm, L.: Influence of oxygen tension on the metabolism of vascular smooth muscle; demonstration of a Pasteur effect. Atherosclerosis 25, 245–253, 1976.

    Article  PubMed  CAS  Google Scholar 

  7. Niinikoski, V., Heughan, C. and Hunt, T.K.: Oxygen tensions in the aortic wall of normal rabbits. Atherosclerosis 17, 353–359, 1973.

    Article  PubMed  CAS  Google Scholar 

  8. Kirk, J.E. and Laursen, T.J.S.: Diffusion coefficients of various solutes for human aortic tissue, with special reference to variation in tissue permeability with age. J. Gerontol. 10, 288–302.

    Google Scholar 

  9. Hill, A.V.: The diffusion of oxygen and lactic acid through tissues. Proc. Roy. Soc. (London) Ser. B., 104, 39–96, 1928–29.

    Google Scholar 

  10. Moss, A.J., Samuelson, P., Angell, C. and Minken, S.L.: Polarographic evaluation of transmural oxygen availability in intact muscular arteries. J. Atheroscler. Res., 8, 803–810, 1968.

    Article  PubMed  CAS  Google Scholar 

  11. Kjeldsen, K., Wanstrup, J. and Astrup, P.: Enhancing influence of arterial hypoxia on the development of atheromatosis in cholesterol-fed rabbits. J. Atheroscler. Res. 8, 835–845, 1968.

    Article  PubMed  CAS  Google Scholar 

  12. Kjeldsen, K., Astrup, P., and Wanstrup, J.: Reversal of rabbit atheromatosis by hyperoxia. J. Atheroscler. Res., 10, 173–178, 1969.

    Article  PubMed  CAS  Google Scholar 

  13. Vesselinovitch, D., and Wissler, R.W.: Experimental atherosclerosis in rabbits - the effect of oxygen and/or cholestyramine on its reversibility. Circ. 38, Suppl. VI, 198, 1968.

    Google Scholar 

  14. Vesselinovitch, D., Wissler, R.W., Dzoga, K., Hughes, R.H., and Dubien, L.: Regression of atherosclerosis in rabbits; Pt. 1, Treatment with low-fat, hyperoxia and hypolipidemic agents. Atheroclerosis 19, 259–275, 1974.

    Article  CAS  Google Scholar 

  15. Zemplenyi, T.: In: The Smooth Muscle of the Artery (Eds. S. Wolf & N.T. Werthessen). Advan. Exp. Med. Biol. 57, 302, 1975.

    Google Scholar 

  16. Peters, T.J.: Lysosomes of the cardiovascular system. Prog. in Cardiol. 4, 151–164, 1975.

    Google Scholar 

  17. Burleigh, M.C., Barrett, A.J. and Lazarus, G.S.: Cathepsin Bl: a lysosomal enzyme that degrades native Collagen. Biochem. J. 137, 387–398, 1974.

    PubMed  CAS  Google Scholar 

  18. de Duve, C., and Wattiaux, R.: Functions of lysosomes. Ann. Rev. Physiol., 28, 435–492.

    Google Scholar 

  19. Brachfeld, N.: Maintenance of cell viability. Circ. Suppl. 4, Vols. 39–40, 202–214, 1969.

    Google Scholar 

  20. Robin, E.D., Wilson, R.J., and Bromberg, P.A.: Intracellular acid-base relations and intracellular buffers. Ann. N.Y. Acad. Sci. 92. 539–546, 1961.

    Article  PubMed  CAS  Google Scholar 

  21. Reijngoud, D.J., and Tager, J.M.: Measurement of intralysosomal pH. Biochem. Biophys. Acta. 297, 174–178, 1973.

    Article  CAS  Google Scholar 

  22. Ravens, K.G. and Gudbjarnason, S.: Changes in the activities of lysosomal enzymes in infarcted canine heart muscle. Circl. Res. 24, 851–856, 1969.

    Article  CAS  Google Scholar 

  23. Ricciutti, M.A.: Myocardial lysosome stability in the early stages of acute ischaemic injury. Am. J. Cardiol. 30, 492–497, 1972.

    Article  PubMed  CAS  Google Scholar 

  24. Ricciutti, M.A.: Lysosomes and myocardial cellular injury. Am. J. Cardiol. 30, 498–502, 1972.

    Article  PubMed  CAS  Google Scholar 

  25. Welman, E.: Lysosomal changes during anoxia in guinea-pig heart. Biochem. Soc. Trans. 2, 746–748.

    Google Scholar 

  26. Stary, H.C.: Coronary artery fine structure in Rhesus monkeys: the early atherosclerotic lesion and its progression. Primates in Medicine 9, 359–395, 1976.

    PubMed  CAS  Google Scholar 

  27. Whereat, A.F.: Atherosclerosis and metabolic disorder in the arterial wall. Exp. Mol. Path. 7, 233–247, 1967.

    Article  CAS  Google Scholar 

  28. Portman, O.W. and Illingworth, D.R.: Arterial metabolism in primates. Prim. Med. 9, 145–223.

    Google Scholar 

  29. St. Clair, R.W.: Metabolism of the arterial wall and atherosclerosis. Atherosclerosis Revs. 1, 61–117, 1976.

    Google Scholar 

  30. Haust, M.D.: The morphogenesis and fate of potential and early atherosclerotic lesions in man. Hum. Pathol. 2, 1–29, 1971.

    Article  PubMed  CAS  Google Scholar 

  31. Smith, E.B. and Slater, R.S.: Lipids and low-density lipoproteins in intima in relation to its morphological characteristics. In: Atherogenesis: Initiating factors. Ciba Symp. No. 12 (NS) 39–52, 1973.

    Google Scholar 

  32. Smith, E.B. and Smith, R.H.: Early changes in aortic intima. Atherosclerosis Revs. 1, 119–136, 1976.

    CAS  Google Scholar 

  33. Smith, E.B.: Acid glycosaminoglycan, collagen and elastin content of normal artery, fatty streaks and plaques. In: Arterial Mesenchyme and Atherosclerosis (Eds. W.D. Wagner and T.B. Clarkson) Advan. Exper. Med. Biol. 43, 125–138, 1974.

    Google Scholar 

  34. Lindner, J.: Regressive und progressive arterielle Reaktionen bei Atherosklerose: 5. Veranderungen im extracellularen Kompartment. Verh. Dt. Ges. inn. Med. 78, 1166–1175, 1972.

    CAS  Google Scholar 

  35. Green, H. and Goldberg, B.: Collagen and cell protein synthesis by an established mammalian fibroblast line. Nature. 204, 347–349, 1964.

    Article  PubMed  CAS  Google Scholar 

  36. Langness, U. and Udenfriend, S.: Collagen proline hydroxylase activity and anaerobic metabolism. In: Biology of fibroblast (E. Kulonen & J. Pikkarainen) Academic Press, 373–377, 1973.

    Google Scholar 

  37. Levene, C.I. and Bates, C.J.: The activation of protocollagen proline hydroxylase and its effect on collagen synthesis in culture 3T6 fibroblasts. Ital. J. Biochem. 24, 36, abs. 1975.

    Google Scholar 

  38. Schwarz R., Colarusso, L. and Doty, P.: Maintenance of differentiation in primary cultures of avian tendon cells. Exp. Cell Res. 102, 63–71, 1976.

    Article  PubMed  CAS  Google Scholar 

  39. Chvapil, M., Hurych, J. and Mirejovska, E.: Effect of long-term hypoxia on protein synthesis in granuloma and in some organs in rats. Proc. Soc. Exp. Biol. Med. 135, 613–617, 1970.

    PubMed  CAS  Google Scholar 

  40. Hunt, T.K. and Pai, M.P.: The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg. Gyn. Obs. 135, 561–567, 1972.

    CAS  Google Scholar 

  41. Bedford, J.S. and Mitchell, J.B.: The effect of hypoxia on the growth and radiation response of mammalian cells in culture. Brit. J. Radiol. 47, 687–606, 1974.

    Article  PubMed  CAS  Google Scholar 

  42. Leung, D.Y.M., Glagov, S., Clark, J.M. and Mathews, M.B.: Mechanical influences on the biosynthesis of extracellular macromolecules by aortic cells. In: Extracullular Matrix Influences on Gene Expression. (Eds. H.C. Slavkin & R.C. Greulich). Academic Press 633–645, 1975.

    Google Scholar 

  43. Leung, D.Y.M., Glagov, S., and Mathews, M.B.: Cyclic stretching stimulates synthesis of matrix components by arterial smooth muscle cells in vitro. Science 191, 475–477, 1976.

    Article  PubMed  CAS  Google Scholar 

  44. Norby, D.P., Malemud, C.J. and Sokoloff, L.: Modulation of phenotypic expression of collagen synthesis by lapine articular chondrocytes in spinner and mono-layer cultures. Fed. Proc. 35, 714 (abs) 1976.

    Google Scholar 

  45. Wolinsky, H.: Effects of hypertension and its reversal on the thoracic aorta of male and female rats. Circulation Res. 28, 622–637, 1971.

    Article  PubMed  CAS  Google Scholar 

  46. Wolinsky, H.: Long term effects on hypertension on the rat aortic wall and their relation to concurrent aging changes. Circulation Res. 30, 301–309, 1972.

    Article  PubMed  CAS  Google Scholar 

  47. Hollander, W., Kramsch, D.M., Farmelant, M. and Madoff, I.M.: Arterial wall metabolism in experimental hypertension of coarctation of the aorta of short duration. J. Clin. Invest. 47, 1221–1229, 1968.

    Article  PubMed  CAS  Google Scholar 

  48. Fernandez, D. and Crane, W.A.J.: New cell formation in rats with accelerated hypertension due to partial constriction. J. Path., 100, 307–316, 1970.

    Article  PubMed  CAS  Google Scholar 

  49. Smith, E.B., Alexander, K.M. and Massie, I.B.: Insoluble “fibrin” in human aortic intima: quantitative studies on the relationship between insoluble “fibrin” soluble fibrinogen and low density lipoprotein. Atherosclerosis 23, 19–39, 1976.

    Article  PubMed  CAS  Google Scholar 

  50. Smith, E.B. and Crothers, D.C.: Interaction between plasma proteins and the intercellular matrix in human aortic intima. Protides of the Biological Fluids, 22, 315–318, 1974.

    CAS  Google Scholar 

  51. Fisher-Dzoga, K., Chen, R. and Wissler, R.W.: Effect of serum lipoproteins on the morphology, growth and metabolism of arterial smooth muscle cells. Advan. Exp. Med. Biol., 43, 299–311, 1974.

    Article  CAS  Google Scholar 

  52. Ross, R.: The smooth muscle of the artery. Advan. Exp. Med. Biol. 57, 64–79, 1975.

    Google Scholar 

  53. Ronnemaa, J., Juva, K., and Kulonen, E.: Effect of hyperlipidemic rat serum on the synthesis of collagen by chick embryo fibroblasts. Atherosclerosis, 21, 315–324, 1975.

    Article  PubMed  CAS  Google Scholar 

  54. Fuller, G.C., Miller, E., Farber, T. and Vanloon, E.: Aortic connective tissue changes in miniature pigs fed a lipid-rich diet. Connective Tiss. Res. 1, 217–220, 1972.

    Article  CAS  Google Scholar 

  55. St. Clair, R.W., Toma, J. J. and Lofland, H.B.: Proline hydroxylase activity and collagen content of pigeon aortas with naturally-occurring and cholesterol-aggravated atherosclerosis. Atherosclerosis, 21, 155–165, 1975.

    Article  PubMed  CAS  Google Scholar 

  56. McCullagh, K.G. and Ehrhart, L.A.: Increased arterial collagen synthesis in experimental canine atherosclerosis Atherosclerosis, 19, 13–28, 1974.

    Article  PubMed  CAS  Google Scholar 

  57. Smith, E.B., Massie, I.B. and Alexander, K.M.: The release of an immobilized lipoprotein fraction from atherosclerotic lesions by incubation with plasmin. Atherosclerosis, 25, 71–84, 1976.

    Article  PubMed  CAS  Google Scholar 

  58. Smith, E.B.: Arterial wall and lipoproteins - steady state aspects. Proc. IV International Symposium on Atherosclerosis, Tokyo, 1976. In Press.

    Google Scholar 

  59. Camejo, G., Lopez, A., Vegas, H., and Paoli, H.: The participation of aortic proteins in the formation of complexes between low density lipoproteins and intima-media extracts. Atherosclerosis, 21, 77–91, 1975.

    Article  PubMed  CAS  Google Scholar 

  60. Tracy, R.E., Dzoga, K., and Wissler, R.W.: Sequestration of serum low density lipoproteins in the arterial intima by complex formation. Proc. Soc. Exp. Biol. Med., 118, 1095–1098, 1965.

    PubMed  CAS  Google Scholar 

  61. Bihari-Varga, M. and Vegh, M.: Quantitative studies on the complexes formed between aortic mucopolysaccharides and serum lipoproteins. Biochem. Biophys. Acta., 144, 202–210, 1967.

    Article  PubMed  CAS  Google Scholar 

  62. Srinivasan, S.R., Dolan, P., Radhakrishnamurthy, B. and Berenson, G.S.: Isolation of lipoprotein-acid mucopolysaccharide complexes from fatty streaks of human aortas. Atherosclerosis, 16, 95–104, 1972.

    Article  PubMed  CAS  Google Scholar 

  63. Anderson, A.J.: The formation of chondromucoproteinfibrinogen and chondromucoprotein-B-lipoprotein complexes. Biochem. J., 88, 460, 1963.

    PubMed  CAS  Google Scholar 

  64. Benditt, E.P. and Benditt, J.M.: Evidence for a monoclonal origin of human atherosclerotic plaques. Proc. Nat. Acad. Sci. U.S.A., 70, 1753–1756, 1973.

    Article  CAS  Google Scholar 

  65. Panganamala, R.V., Geer, J.C., Sharman, H.M. and Cornwell, D.G.: The gross and histologic appearance and the lipid composition of normal intima and lesions from human coronary arteries and aorta. Atherosclerosis, 20, 93–104, 1974.

    Article  PubMed  CAS  Google Scholar 

  66. Pearson, T.A., Wang, A., Solez, K. and Heptinstall, R.H.: Clonal characteristics of fibrous plaques and fatty streaks from human aortas. Am. J. Pathol., 81, 379–387, 1975.

    PubMed  CAS  Google Scholar 

  67. Lee, K.T., Imai, H., Werthessen, N.T., and Taylor, C.B.: Necrogenic agent obtained from cholesterol used in dietary experiments. In: Atherosclerosis III (Eds. G. Schettler and A. Weizel ) 344–347, 1974.

    Chapter  Google Scholar 

  68. Florentine, R.A., Nam, S.C., Lee, K.T., Lee, K.J., and Thomas, W.A.: Increased mitotic activity in aortas of swine. Arch. Path., 88, 463–469, 1969.

    Google Scholar 

  69. Stary, H.C. and McMillan, G.C.: Kinetics of cellular proliferation in experimental atherosclerosis. Arch. Path., 89, 173–183, 1970.

    PubMed  CAS  Google Scholar 

  70. Smith, E.B. and Massie, I.B.: Destruction of endogenous low density lipoprotein in incubated intima. Atherosclerosis. In press.

    Google Scholar 

  71. Miller, B.F. and Kothari, H.V.: Increased activity of lysosomal enzymes in human atherosclerotic aortas. Exp. Mol Path., 10, 288–294, 1969.

    Article  CAS  Google Scholar 

  72. Zemplenyi, T.: Vascular enzymes and the relevance of their study to problems of atherogenesis. Med. Clin. of North Amer., 58, (no.2), 293–321, 1974.

    CAS  Google Scholar 

  73. Oliver, M.F.: Dietary cholesterol, plasma cholesterol and coronary heart disease. Brit. Heart J., 38, 214–218, 1976.

    Article  PubMed  CAS  Google Scholar 

  74. Day, A.J. and Proudlock, J.W.: Changes in aortic cholesterol-esterifying activity in rabbits fed cholesterol for 3 days. Atherosclerosis, 19, 253–258, 1974.

    Article  PubMed  CAS  Google Scholar 

  75. Goldstein, J.L. and Brown, M.S.: Lipoprotein receptors, cholesterol and metabolism and atherosclerosis. Arch. Pathol., 99 181–184, 1975.

    PubMed  CAS  Google Scholar 

  76. Weinstein, D.B., Carew, T.E. and Steinberg, D.: Uptake and degradation of low density lipoprotein by swine arterial smooth muscle cells with inhibition of cholesterol biosynthesis. Biochim. Biophys. Acta, 424, 404–421, 1976.

    Article  PubMed  CAS  Google Scholar 

  77. Stein, Y., Glangeaud, M.C., Fainaru, M. and Stein, O.: The removal of cholesterol from aortic smooth muscle cells in culture and Landschutz ascites cells by fractions of human high density apolipoprotein.

    Google Scholar 

  78. Brown, M.S., Faust, J.R. and Goldstein, J.L.: Role of the low density lipoprotein receptors in regulating the content of free and esterified cholesterol in human fibroblasts. J. Clin. Invest., 55, 783–793, 1975.

    Article  PubMed  CAS  Google Scholar 

  79. Werb, Z. and Cohn, Z.A.: Cholesterol metabolism in the macrophage, III. Ingestion and intracellular fate of cholesterol and cholesterol esters. J. Exp. Med., 135, 21–44, 1972.

    Article  PubMed  CAS  Google Scholar 

  80. Holman, R.L.: Atherosclerosis–a pediatric nutrition problem? Am. J. Clin. Nutr., 9, 565–569, 1961.

    PubMed  CAS  Google Scholar 

  81. Lee, V.A.: Individual trends in the total serum cholesterol of children and adolescents over a ten-year period. Am. J. Clin. Nutr., 20, 5–12, 1967.

    PubMed  CAS  Google Scholar 

  82. Stetten, M.R.: Some aspects of metabolism of hydroxyproline, studied with aid of isotopic nitrogen. J. Biol. Chem. 181, 31, 1949.

    PubMed  CAS  Google Scholar 

  83. Pearson, T.A., Wang, A., Solez, K., and Heptinstall, R.H.: Clonal characteristics of fibrous plaques and fatty streaks from human aortas. Am. J. Path. 81, 379–387, 1975.

    PubMed  CAS  Google Scholar 

  84. Wolinsky, H., Glagov, S.: A lamellar unit of aortic medial structure and function in mammals. Circ. Res., 20: 99–111, 1967.

    Article  PubMed  CAS  Google Scholar 

  85. Gospodarowicz, D., Moran, J.S.: Growth factors in mammalian cell culture. Ann. Rev. of Biochem. 45: 531, 1976.

    Article  CAS  Google Scholar 

  86. Ross, R., and Glomsett, J.A.: The pathogenesis of atherosclerosis. N. Eng. J. Med. 295–369, 1976.

    Google Scholar 

  87. Adams, C.W.M. and Bayliss, O.B.: The relationship between diffuse intimal thickening, medial enzyme failure and intimal lipid deposit in various human arteries. J. Athero. Res., 10: 327, 1969.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Plenum Press, New York

About this chapter

Cite this chapter

Wolf, S., Werthessen, N.T. (1979). Metabolic Activities in the Arterial Wall. In: Wolf, S., Werthessen, N.T. (eds) Dynamics of Arterial Flow. Advances in Experimental Medicine and Biology, vol 115. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7508-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7508-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7510-4

  • Online ISBN: 978-1-4684-7508-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics