Abstract
Davies and Lowe (2,3) demonstrated that guinea pig serum contains a permeability factor distinct from anaphylatoxin after incubation with immune aggregates. It has also been shown that such treatment activates the kininforming system (5, 6). In the course of investigations into the components of the guinea pig intrinsic plasma kinin-forming system, a kinin-forming component has been differentiated from kallikrein by its inability to generate kinin from plasma heated to 61° for 60 minutes (8). This activator can be adsorbed to antigen-antibody precipitates and subsequently eluted (10). The isolated material possesses potent vascular permeability enhancing activity and the ability to contract the isolated rat uterus when incubated with fresh, non-glass contacted plasma. These properties have been used in the further isolation, purification and characterization of this material as an activator of plasma prekallikrein.
Supported by the Atkinson Charitable Foundation.
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References
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Treloar, M.P., Pyle, H.A., Fuller, P.J., Movat, H.Z. (1972). Guinea Pig Prekallikrein Activator. In: Back, N., Sicuteri, F. (eds) Vasopeptides. Advances in Experimental Medicine and Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7439-8_8
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DOI: https://doi.org/10.1007/978-1-4684-7439-8_8
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