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Dissociation of Oedema Provoking Factor of Agkistrodon Piscivorus Venom from Kininogenase

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Vasopeptides

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 21))

Abstract

The development of a method for measuring the hemorrhagic activity qualitatively as well as quantitatively by Bonta et al. (1) made it possible to characterise the hemorrhagic factors of some venoms. These factors were revealed to be basic polypeptides of less than 10,000 molecular weight. Since hemorrhages are known to accompany a variety of allergic inflammations and since it has also been found that oestriol succinate inhibits the hemorrhages (2) as well as the cobra venom induced rat paw oedema (3,9), it seemed worthwhile investigating whether some venom fractions which induce pulmonary hemorrhages are able to induce oedema. In addition some chemical and pharmacological properties of these fractions have been investigated.

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Reference

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Author information

Authors and Affiliations

  1. Research Laboratories of N.V. Organon, Oss, The Netherlands

    N. Bhargava, B. B. Vargaftig, C. J. de Vos, I. L. Bonta & T. Tijs

  2. Organon S.A., Eragny-sur-Epte, France

    N. Bhargava, B. B. Vargaftig, C. J. de Vos, I. L. Bonta & T. Tijs

  3. Department of Pharmacology, Medical Faculty Rotterdam, The Netherlands

    N. Bhargava, B. B. Vargaftig, C. J. de Vos, I. L. Bonta & T. Tijs

Authors
  1. N. Bhargava
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  2. B. B. Vargaftig
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  3. C. J. de Vos
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  4. I. L. Bonta
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  5. T. Tijs
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Editor information

Editors and Affiliations

  1. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

  2. Department of Clinical Pharmacology, University of Florence, Florence, Italy

    F. Sicuteri

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© 1972 Plenum Press, New York

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Bhargava, N., Vargaftig, B.B., de Vos, C.J., Bonta, I.L., Tijs, T. (1972). Dissociation of Oedema Provoking Factor of Agkistrodon Piscivorus Venom from Kininogenase. In: Back, N., Sicuteri, F. (eds) Vasopeptides. Advances in Experimental Medicine and Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7439-8_18

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  • DOI: https://doi.org/10.1007/978-1-4684-7439-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7441-1

  • Online ISBN: 978-1-4684-7439-8

  • eBook Packages: Springer Book Archive

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