Abstract
In a previous paper (Mochizuki et al., 1986) we described the relation between alveolar- and venous-Pco2 and the contact time (tc). However, at that time, Pco2-dependency of the arterio-venous difference in O2 content ((a-v)Co2), the contact-time-dependency of the Haldane effect, and linearity of the relation between the experimental gas exchange ratio and Pco2 (R-Pco2 line) in rebreathing air were not taken into account. Recently, we have precisely analysed the above correlations from the numerical solutions of the simultaneous O2 and CO2 diffusions in the red blood cell (RBC). Based upon the results we have derived a corrected contact time equation. When the time constant of the reaction rate of the extracellular dehydration reaction was less than 0.2 sec, good agreement was observed between the contact time obtained from the pulmonary diffusing capacity for CO (Uchida, Shibuya and Mochizuki, 1986) and that from the present method.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bidani, A., Mathew, S.J. and Crandall, E.D. (1983). Pulmonary vascular carbonic anhydrase activity. J. Appl. Physiol: Respir. Envir. Exercise Physiol. 55, 75–83.
Klocke, R.A. (1978). Catalysis of CO2 reactions by lung carbonic anhydrase. J. Appl. Physiol. 44, 882–888.
Mochizuki, M. and Kagawa, T. (1986) Numerical solution of partial differential equations describing the simultaneous O2 and CO2 diffusions in the red blood cell. Jpn. J. Physiol. 36, 43–63.
Mochizuki, M., Kagawa, T., Uchida, K. and Shibuya, I. (1986). Relation between the contact time and venous and alveolar Pco2 at rest. In: Oxygen Transport to Tissue-VIII. Ed. Longmuir, I.S., Plenum Press, New York and London, ( Adv. Exp. Med. Biol. 200, 27–34 ).
Mochizuki, M. Tamura, M., Shimasaki, T., Niizeki, K. and Shimouchi, A. (1984). A new indirect method for measuring arteriovenous O2 content difference and cardiac output from O2 and CO2 concentrations by rebreathing air. Jpn. J. Physiol. 34, 295–306.
Shibuya, I., Uchida, K. and Mochizuki, M. (1987). Quantitative relations between gas exchange parameters including contact time at rest and during exercise. This volume.
Tazawa, H., Mochizuki, M., Tamura, M., and Kagawa, T. (1983) Quantitative analyses of the CO2 dissociation curve of oxygenated blood and the Haldane effect in human blood. Jpn. J. Physiol. 33, 601–618.
Uchida, K., Shibuya, I. and Mochizuki, M. (1986). Simultaneous measurement of cardiac output and pulmonary diffusing capacity for CO by a rebreathing method. Jpn. J. Physiol. 36, 657–670.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Mochizuki, M., Shibuya, I., Uchida, K., Kagawa, T. (1987). A Method for Estimating Contact Time of Red Cells in Lung Capillaries from O2 and CO2 Concentrations in Rebreathing Air in Man. In: Silver, I.A., Silver, A. (eds) Oxygen Transport to Tissue IX. Advances in Experimental Medicine and Biology, vol 215. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7433-6_7
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7433-6_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7435-0
Online ISBN: 978-1-4684-7433-6
eBook Packages: Springer Book Archive