Summary
Exposure of rats to high concentrations of oxygen (> 95%) at 1 ATA pressure (101 kPa) is lethal within three days. Rats treated with a small dose of endotoxin are protected against these lethal effects of hyperoxia. Recently, we found that the lysine salt of acetylsalicylic acid antagonises this protective action of endotoxin. This suggests that prostaglandin metabolism plays an important role in the protective action of endotoxin against pulmonary oxygen toxicity. Therefore, we measured the plasma levels of 6KPGF1∝, a stable degradation product of prostacyclin (PGI2), PGE2 and thromboxane B2, the stable degradation product of thromboxane A2, in rats exposed to air or > 95% oxygen for 48 hours. We compared these with the plasma levels of rats treated with endotoxin (Salmonella typhimurium lipopolysaccharide 1 mg/kg) and exposed to air or > 95% oxygen for 48 hours. We found that exposure of rats to > 95% oxygen for 48 hours leads to a significant rise in the 6KPGF1∝ levels. Rats exposed to > 95% oxygen for 48 hours and treated with endotoxin had significantly higher PGE2 and significantly lower 6KPGF1∝ plasma levels than saline-treated rats exposed to > 95% oxygen for 48 hours.
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References
Fox, R.B., Hoidal, J.R., Brown, D.M. and Repine, J.E. (1981). Pulmonary inflammation due to oxygen toxicity: involvement of chemotactic factors and polymorphonuclear leukocytes. Am. Rev. Respir. Dis., 123, 521-523.
Frank, L. and Roberts, R.J. (1979). Oxygen toxicity: protection of the lung by the bacterial lipopolysaccharide (endotoxin). Toxicol. Appl. Pharmac. 50, 371-380.
Frank, L., Summerville, J. and Massaro, D. (1980). Protection from oxygen toxicity with endotoxin: role of the endogenous antioxidant enzymes of the lung. J. Clin. Invest. 65, 1104-1110.
Ham, E.A., Soderman, D.D., Zanetti, M.E., Dougherty, H.W., McCauley, E. and Kuehl, F.A., Jr (1983). Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils. Proc. Natl. Acad. Sci. USA, 80, 4349-4353.
Klein, J., Trouwborst, A. and Salt, P.J. (1986). Endotoxin protection against oxygen toxicity and its reversal by acetylsalicylic acid. Crit. Care Med. 14, 32-33.
Taniguchi, H., Taki, F., Takagi, K., Satake, T., Sugiyama, S. and Ozawa, T. (1986). The role of leukotriene B4 in the genesis of oxygen toxicity in the lung. Am. Rev. Respir. Dis., 133, 805-808.
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© 1987 Plenum Press, New York
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Klein, J., Trouwborst, A., Erdmann, W. (1987). Endotoxin Protection against Pulmonary Oxygen Toxicity and Plasma Prostaglandin Levels in the Rat. In: Silver, I.A., Silver, A. (eds) Oxygen Transport to Tissue IX. Advances in Experimental Medicine and Biology, vol 215. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7433-6_42
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DOI: https://doi.org/10.1007/978-1-4684-7433-6_42
Publisher Name: Springer, Boston, MA
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