Abstract
In a previous study on the effects of normovolaemic haemodilution with Hetastarch on cerebral cortical oxygenation and perfusion, we found that cortical tissue PO2 (PtO2) was unchanged between haematocrits (Hct) of 45 to 38%, but then fell at a rate of about 2.4% per 1% decrease in Hct between Hct of 38% to 5% (Shinozuka, Nemoto and Bleyaert, 1984). Fluosol-DA may delay the fall in cerebral cortical PtO2 during normovolaemic haemodilution compared with haemodilution with Hetastarch.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Handa, H., Nagasawa, S., Yonekawa, Y., Naruo, Y. and Oda, Y. (1983). New treatment of cerebral vasospasm with Fluosol-DA 20%: protective effect on cerebral ischemia and change of cerebral blood flow (CBF). Progress in Clinical and Biological Research, Vol. 122, Alan R. Liss, Inc., New York, pp. 299–306.
Kessler, M., Vogel, H. and Gunther, H. (1983). Local oxygen supply of the myocardium after extreme hemodilution with Fluosol-DA. Progress in Clinical and Biological Research, Vol. 122, Alan R. Liss, Inc., New York, pp. 237–248.
Kolluri, S., Heros, R.C., Hedley-Whyte, E.T., Vonsattel, J. P., Miller, D. and Zervas, N.T. (1986). Effect of Fluosol on oxygen availability. Regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia. Stroke, 17, 976–980.
Naito, R. and Yokoyama, K. (1978). Fluosol-DA. In: Perfluorochemical Blood Substitutes. Technical Information Series No. 5. The Green Cross Corporation, Osaka.
Shinozuka, T., Nemoto, E.M. and Bleyaert, A.L. (1984). Cerebral cortical oxygenation and perfusion during Hetastarch hemodilution. In: Oxygen Transport to Tissue-VI. Eds Bruley, D., Bicher, H.I. and Reneau, D., Plenum Press, New York and London, ( Adv. Exp. Med. Biol. 180, 853–860 ).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Shinozuka, T., Nemoto, E.M., Winter, P.M. (1987). Cerebral Cortical Oxygenation and Perfusion during Progressive Normovolaemic Haemodilution with Hetastarch (Volex) and Fluosol-DA. In: Silver, I.A., Silver, A. (eds) Oxygen Transport to Tissue IX. Advances in Experimental Medicine and Biology, vol 215. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7433-6_13
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7433-6_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7435-0
Online ISBN: 978-1-4684-7433-6
eBook Packages: Springer Book Archive