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Degranulation and Intracellular Killing of Bacteria

  • Chapter
The Neutrophil

Abstract

Metchnikoff knew that neutrophils possessed “ferments” capable of digesting gelatin and other proteins, and that phagocytosed grains of litmus sometimes turned red. He knew that organisms taken up by neutrophils were enclosed in vacuoles and not admitted to the cytoplasm proper, and that in the vacuoles they were slowly digested. He said:

We are at present ignorant of the precise manner in which this digestive and other destructive action is accomplished, and do not even know whether the substance which kills the microbes is a ferment or not.

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Authors and Affiliations

  1. The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Patrick Murphy

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  1. Patrick Murphy
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© 1976 Plenum Publishing Corporation

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Murphy, P. (1976). Degranulation and Intracellular Killing of Bacteria. In: The Neutrophil. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7418-3_8

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  • DOI: https://doi.org/10.1007/978-1-4684-7418-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7420-6

  • Online ISBN: 978-1-4684-7418-3

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