Abstract
Photodynamic therapy (PDT) is a selective, experimental treatment for solid tumors. PDT consists of the activation of a photosensitizing agent by light. The photodynamic reaction induced by light causes damage to the tissue containing the photosensitizer in the presence of oxygen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
H. Tappenier and A. Jesionek, “Therapeutische Versuche mit fluoreszierenden Stoffe”, Münch. Med. Wochenschr. 1:2042 (1903)
A. Policard, “Etudes sur les aspects offerts par des tumeurs expérimentales examinées à la lumière de Woods”, Cr. Soc. Biol. 91:1423 (1924)
H. Auler and G. Banzer, “Untersuchungen über die Rolle der Porphine bei geschwulstkranken Menschen und Tieren”, Z. Krebforsch. 53:65 (1942)
R. L. Lipson, E. J. Baldes, “The photodynamic properties of a particular hematoporphyrin derivative”, Arch. Dermatol. 82:508 (1960)
R. L. Lipson, E. J. Balder and A. M. Olsen, “Hematoporphyrin derivative: a new aid for endoscopic detection of malignant disease”, J. Thorac. Cardiovasc. Surg. 42:623 (1961)
J. Moan, “Porphyrin-sensitized photodynamic inactivation of cells: a review”, Lasers Med. Sci. 1:5 (1986)
R. Hilf, D. B. Smail, R. S. Murant, et al., “Hematoporphyrin derivative-induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230 AC mammary adenocarcinomas of rats”, Cancer Res. 44:1483 (1984)
C. J. Gomer, “DNA damage and repair in CHO cells following hematoporphyrin photoradiation”, Cancer Lett. 11:161 (1980)
J. Dougherty, “Photodynamic therapy (PDT) of malignant tumors”, CRC Crit. Rev. Oncol/Haemat. 2:83 (1985)
T. J. Dougherty, W. R. Potter and K. R. Weishaupt, “The structure of the active component of hematoporphyrin derivative”, In “Porphyrin Localization and Treatment of Tumors (D. R. Doiron and C. J. Gomer, eds.), Alan R. Liss, Inc., New York, 301 (1984)
G. Jori, “Pharmacokinetics studies with hematoporphyrin in tumor-bearing mice”, in “Photodynamic Therapy of Tumors and other Diseases”, G. Jori, C. Perria eds., Progetto Publ., Padova, 159 (1985)
D. Mew, C. K. Wat, G. H. N. Towers and J. G. Levy, “Photoimmunotherapy: treatment of animal tumors with tumor specific monoclonal antibody-hematoporphyrin conjugates”, J. Immunol. 130:1473 (1983)
R. Kol, E. Ben-Hur, E. Riklis, R. Marko and I. Rosenthal, “Photosensitized inhibition of mitogenic stimulation of human lymphocytes by aluminium phtalocyanine tetrasulphonate”, Las. Med. Sci. 1:187 (1986)
A. M. Richter, E. Sternberg, E. Waterfield, D. Dolphin and J. C. Levy, “Characterization of benzoporphyrin derivative, a new photosen-sitizer”, Proc. SPIE 997:132 (1988)
T. J. Dougherty, J. E. Kaufman, A. Goldfarb, K. R. Weishaupt, D. G. Boyle and A. Mittleman, “Photoradiation therapy for the treatment of malignant tumors”, Cancer Res. 38:2628 (1978)
P. Spinelli and M. Dal Fante, “Photodynamic therapy” In G. I. tract”, Acta Endosc. 15:69 (1985)
J. A. Parrish, “Photomedicine potential for lasers. An overview from lasers in photomedicine and photobiology”, R. Pratesi and C. A. Sacchi eds., Springer, Berlin, 2 (1980)
A. L. McKenzie and J. A. S. Carruth, “A comparison of gold-vapour and dye lasers for PDT”, Laser Med. Sci. 1:117 (1986)
T. J. Dougherty, “Photodynamic therapy - New approaches”, Sem. Surg. Oncol. 5:6 (1989)
R. Brancato, L. Giovannoni, R. Pratesi and U. Vanni, “New lasers for ophtalmology: retinal photocoagulation with pulsed diode lasers”, Proc. SPIE 701:365 (1986)
P. Spinelli and M. Dal Fante, “Contact laser endoscopic surgery with sapphire microprobes”, Proc. SPIE 701:331 (1986)
V. Russo, “Optical fiber delivery systems for laser medical applications” in “Photodynamic Therapy of Tumors and other Diseases”, G. Jori, C. Perria eds., Progetto Publ. Padova, 371 (1985)
Y. Hayata, H. Kato, C. Konaka, J. Ono and N. Takizawa, “Hematoporphyrin-derivative and laser photoradiation in the treatment of lung cancer”, Chest 81:269 (1981)
P. Spinelli and M. Dal Fante, “PDT - State of the art”, in “Laser Opto electronics in Medicine”, W. Waidelich and P. Kiefhaber eds., Springer Verlag, 609 (1987)
P. Spinelli, S. Andreola, R. Marchesini, E. Melloni, V. Mirabile, P. Pizzetti and F. Zunino, “Endoscopic HpD-laser photoradiation therapy (PRT) of cancer”, In “Porphyrins in Tumor Phototherapy”, A. An-dreoni, R. Cubeddu eds., Plenum Publishing Corporation, 423 (1984)
J. T. Allardice, A. C. Rowland, N. S. Williams and C. P. Swain, “A new light delivery system for the treatment of obstructing gastrointestinal cancers by photodynamic therapy”, Gastrointest. Endosc. 35:548 (1989)
Japanese Study for Gastroenterological Endoscopy. Cited by T. Murakami, “Pathomorphological diagnosis, definition and gross classification of early gastric cancer”, T. Murakami ed., Tokyo, University of Tokyo Press (1971)
M. Dal Fante, G. Bottiroli and P. Spinelli, “Behaviour of haematoporphyrin derivative in adenomas and adenocarcinomas of the colon: a microfluorometric study”, Lasers Med. Sci. 3:165 (1988)
R. M. Cothren, R. Richards-Kortum, M. V. Sivak, Jr., et al., “Gastrointestinal tissue diagnosis by laser-induced fluorescence spectroscopy at endoscopy”, Gastrointest. Endosc, 128 (1990)
E. M. H. Mathus-Vliegen and G. N. J. Tytgat, “Nd:YAG laser photocoagulation in colorectal adenoma. Evaluation of its safety, usefulness, and efficacy”, Gastroenterol. 90:1865 (1986)
H. Kato, C. Konaka, J. Ono, et al. “Preoperative laser photodynamic therapy in combination with operation in lung cancer”, J. Thorac. Cardiovasc. Surg. 90:420 (1985)
R. C. Benson, Jr., “Laser photodynamic therapy for bladder cancer”, Mayo Clin. Proc. 61:859 (1986)
D. Jocham, G. Staehler, C. Caussy, et al., “Integral dye-laser irradiation of photosensitized bladder tumors with the aid of a light-scattering medium”, Prog. Clin. Biol. Res. 170:249 (1984)
H. Tajiri, N. Daizukono, S. N. Joffe and Y. Oguro, “Photoradiation therapy in early gastrointestinal cancer”, Gastrointest. Endosc. 33:88 (1987)
J. S. McCaughan, T. E. Williams and B. H. Bethel, “Palliation of esophageal malignancy with photodynamic therapy”, Am. Thor. Surg. 40:113 (1985)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Spinelli, P., Dal Fante, M., Mancini, A. (1991). Endoscopic Photodynamic Therapy: Clinical Aspects. In: Chester, A.N., Martellucci, S., Scheggi, A.M. (eds) Laser Systems for Photobiology and Photomedicine. NATO ASI Series, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7287-5_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7287-5_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7289-9
Online ISBN: 978-1-4684-7287-5
eBook Packages: Springer Book Archive