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Multiple Forms of Rabbit Cytochrome P450: Comparison of Chemical Physical, Immunological and Biocatalytic Properties

  • Chapter
Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds

Part of the book series: NATO ASI Series Advanced Science Institutes Series ((NSSA,volume 202))

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Abstract

The cytochrome P450 system of the rabbit is one of the most highly characterized of any species. The majority of the P450s characterized in the rabbit contribute to the metabolism of foreign compounds, where the multiple forms of P450 provide both functional diversity as well as redundancy of function. In addition, a variety of factors regulate the expression of the individual forms of P450. These can be ontogenetic factors leading to differential expression with age and tissue or environmental factors which induce specific P450s.

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Authors and Affiliations

  1. Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Eric F. Johnson, Thomas Kronbach, A. Scott Muerhoff, Keith J. Griffin & Usha R. Pendurthi

  2. School of Medicine, University of California San Diego, Cancer Center T-012, La Jolla, California, 92093, USA

    Robert H. Tukey

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  1. Eric F. Johnson
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  2. Thomas Kronbach
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  3. A. Scott Muerhoff
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  4. Keith J. Griffin
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Editors and Affiliations

  1. Middle East Technical University, Ankara, Turkey

    Emel Arinç

  2. University of Connecticut Health Center, Farmington, Connecticut, USA

    John B. Schenkman

  3. North Carolina State University, Raleigh, North Carolina, USA

    Ernest Hodgson

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© 1991 Plenum Press, New York

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Johnson, E.F., Kronbach, T., Muerhoff, A.S., Griffin, K.J., Pendurthi, U.R., Tukey, R.H. (1991). Multiple Forms of Rabbit Cytochrome P450: Comparison of Chemical Physical, Immunological and Biocatalytic Properties. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. NATO ASI Series Advanced Science Institutes Series, vol 202. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7284-4_3

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  • DOI: https://doi.org/10.1007/978-1-4684-7284-4_3

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