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Xenobiotic Regulation of Cytochrome P-450 Gene Expression

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Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds

Part of the book series: NATO ASI Series Advanced Science Institutes Series ((NSSA,volume 202))

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Abstract

The relative amounts of some of the cytochrome P-450 enzymes are known to be selectively increased by chemicals (Conney, 1982, Whit lock, 1986). Especially interesting is the induction of certain forms of cytochrome P-450 by 5,6-benzof lavone (BNF), polycyclic aromatic hydrocarbons (PAH) such as 3-methylcholanthrene, and chloroaromatics like 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), since this induction profoundly influences the metabolism of PAH to ultimate carcinogens that are able to form specific adducts with DNA (Conney, 1982). TCDD is the most potent inducer of these particular forms of cytochrome P-450 (c. f. Poland and Knutson, 1982).

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Author information

Authors and Affiliations

  1. Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, F60, Novum, Huddinge, S-141 86, Sweden

    Mikael Gillner & Jan-Åke Gustafsson

  2. Department of Organic Chemistry, Royal Institute of Technology, S-100 44, Stockholm, Sweden

    Jan Bergman

Authors
  1. Mikael Gillner
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  2. Jan Bergman
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  3. Jan-Åke Gustafsson
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Editors and Affiliations

  1. Middle East Technical University, Ankara, Turkey

    Emel Arinç

  2. University of Connecticut Health Center, Farmington, Connecticut, USA

    John B. Schenkman

  3. North Carolina State University, Raleigh, North Carolina, USA

    Ernest Hodgson

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© 1991 Plenum Press, New York

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Gillner, M., Bergman, J., Gustafsson, JÅ. (1991). Xenobiotic Regulation of Cytochrome P-450 Gene Expression. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. NATO ASI Series Advanced Science Institutes Series, vol 202. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7284-4_16

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  • DOI: https://doi.org/10.1007/978-1-4684-7284-4_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7286-8

  • Online ISBN: 978-1-4684-7284-4

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