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Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds pp 185–198Cite as

Functional Aspects of Protein-Protein Interactions of Cytochrome P450 Cytochrome b5 and Cytochrome P450 Reductase

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Part of the book series: NATO ASI Series Advanced Science Institutes Series ((NSSA,volume 202))

Abstract

While cytochrome P450 has only been known for a relatively short time (1), and its role in xenobiotic metabolism has been known for an even shorter period (2), cytochrome b5 has been known for a much longer time (see review, 3). Both of these hemoproteins are present in the endoplasmic reticulum of a number of tissue, particularly the liver. Only in the last two decades has cytochrome b5 been found to play a role in liver microsomal monooxygenations (4–6). The original report of cytochrome b5 involvement in P450 monooxygenations (7) was an attempt to explain NADH synergism of NADPH-supported drug oxidations (8). Subsequent studies including those discussed in this lecture, have resulted in implication of cytochrome b5 in P450 monooxygenations, but do not explain the earlier reported NADH-synergism.

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Authors and Affiliations

  1. Department of Pharmacology, University of Connecticut Health Center, Farmington, CT, 06032, USA

    John B. Schenkman

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  1. John B. Schenkman
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Editors and Affiliations

  1. Middle East Technical University, Ankara, Turkey

    Emel Arinç

  2. University of Connecticut Health Center, Farmington, Connecticut, USA

    John B. Schenkman

  3. North Carolina State University, Raleigh, North Carolina, USA

    Ernest Hodgson

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© 1991 Plenum Press, New York

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Schenkman, J.B. (1991). Functional Aspects of Protein-Protein Interactions of Cytochrome P450 Cytochrome b5 and Cytochrome P450 Reductase. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. NATO ASI Series Advanced Science Institutes Series, vol 202. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7284-4_11

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  • DOI: https://doi.org/10.1007/978-1-4684-7284-4_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7286-8

  • Online ISBN: 978-1-4684-7284-4

  • eBook Packages: Springer Book Archive

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