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In Vivo Correlates of In Vitro Studies of Axonal Guidance: Retinal Transplantation in the Mammalian Retinotectal System

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Part of the book series: NATO ASI Series ((NSSA,volume 192))

Abstract

It is nearly 100 years since Ramón y Cajal first described the bulbous ends of immature axons (see Ramón y Cajal, 1937), and 80 years since Harrison (1910) provided convincing evidence that these structures were, indeed, growth cones. In the intervening time, a great deal of interest has been directed towards elucidating the mechanisms by which axons are first guided along their pathway of outgrowth to their target regions, and then are matched with appropriate sets of neurons to form functional synaptic circuits.

This chapter to be cited as: Hankin, M., and Lund, R., 1990, In vivo correlates of in vitro studies of axonal guidance: retinal transplantation in the mammalian retinotectal system, in: “Systems Approaches to Developmental Neurobiology,” P. A. Raymond, S. S. Easter, Jr., and G. M. Innocenti, eds., Plenum Press, New York.

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References

  • Altman, J., and Bayer, S.A., 1981, Time origins of neurons of the rat superior colliculus in relation to other components of the visual and visuomotor pathways, Exp. Brain Res., 42:424.

    PubMed  CAS  Google Scholar 

  • Barnstable, C.J., and Drager, U.C., 1984, Thy-1 antigen: a ganglion cell specific marker in rodent retina, Neuroscience, 11:847.

    Article  PubMed  CAS  Google Scholar 

  • Coffey, P.J., Lund, R.D., and Rawlins, J.N.P., Retinal transplant-mediated learning on a conditioned suppression task in rats, Proc. Natl. Acad. Sci. USA, 18:7248.

    Google Scholar 

  • Cohen, J., Burne, J.F., McKinlay, C., and Winter, J., 1987, The role of laminin and the laminin/fibronectin receptor complex in the outgrowth of retinal ganglion cell axons, Dev. Biol, 122:407.

    Article  PubMed  CAS  Google Scholar 

  • Craner, S.L., Radel, J.D., Jen, L.S., and Lund, R.D., 1989, Light-evoked cortical activity produced by illumination of intracranial retinal transplants: experimental studies in rats, Exp. Neurol., 104:93.

    Article  PubMed  CAS  Google Scholar 

  • Edwards, M.A., Caviness, V.S.Jr., and Schneider, G.E., 1986, Development of cell and fiber lamination in the mouse superior colliculus, J. Comp. Neurol, 248:395.

    Article  PubMed  CAS  Google Scholar 

  • Galli, L., Rao, K.R., and Lund, R.D., 1989, Transplanted rat retinae do not project on a topographic fashion on the host tectum, Exp. Brain Res., 74:427.

    Article  PubMed  CAS  Google Scholar 

  • Hankin, M.H., and Lund, R.D., 1987, Role of the target in directing the outgrowth of retinal axons: ransplants reveal surface-related and surface-independent cues, J. Comp. Neurol., 263:455.

    Article  PubMed  CAS  Google Scholar 

  • Harris, W.A., 1986, Homing behavior of axons in the vertebrate brain, Nature, 320:266.

    Article  PubMed  CAS  Google Scholar 

  • Harris, W.A., 1989, Local positional cues in the neuroepithelium guide retinal axons in embryonic Xenopus brain, Nature, 339:218.

    Article  PubMed  CAS  Google Scholar 

  • Harrison, R.G., 1910, The outgrowth of the nerve fiber as a mode of protoplasmic movement, J. Exp. Zool., 9:787.

    Article  Google Scholar 

  • Klassen, H., and Lund, R.D., 1987, Retinal transplants can drive a pupillary reflex in host rat brains, Proc. Natl. Acad. Sci. USA, 84:6958.

    Article  PubMed  CAS  Google Scholar 

  • Klassen, H., and Lund, R.D., 1988, Anatomical and behavioral correlates of xenograft-mediated pupillary reflex, Exp. Neurol., 102:102.

    Article  PubMed  CAS  Google Scholar 

  • Lagenaur, C.F., Fushiki, S., and Schachner, M., 1984, Monoclonal antibody M6 blocks neurite extension in cultured mouse cerebellar neurons, Soc. Neurosci. Abstr., 10:759.

    Google Scholar 

  • LaVail, J.H., and Cowan, W.M., 1971, The development of the chick optic tectum. II. Autoradiographic studies, Brain Res., 28:421.

    Article  PubMed  CAS  Google Scholar 

  • Liesi, P., and Silver, J., 1988, Is astrocyte laminin involved in axon guidance in the mammalian CNS?, Dev. Biol., 130:774.

    Article  PubMed  CAS  Google Scholar 

  • Lumsden, A.G.S., and Davies, A.M., 1983, Earliest sensory nerve fibers are guided to peripheral targets by attractants other than nerve growth factor, Nature, 306:786.

    Article  PubMed  CAS  Google Scholar 

  • Lund, R.D., and L.E. Westrum, 1966, Neurofibrils and the Nauta method, Science, 153:1397.

    Article  Google Scholar 

  • Lund, R.D., and Haushka, S.D., 1976, Transplanted neural tissue develops connections with host rat brain, Science, 193:583.

    Article  Google Scholar 

  • Lund, R.D., Chang, F.-L.F., Hankin, M.H., and Lagenaur, C.F., 1985, Use of a species-specific antibody for demonstrating mouse neurons transplanted to rat brains, Neurosci. Lett., 61:221.

    Article  PubMed  CAS  Google Scholar 

  • Lund, R.D., Perry, V.H., and Lagenaur, C.F., 1986, Cell surface changes in the developing optic nerve of mice, J. Comp. Neurol., 247:439.

    Article  PubMed  CAS  Google Scholar 

  • Lund, R.D., K.R. Rao, M.H. Hankin, H.W. Kunz, and T.J. Gill Jr, 1987, Transplantation of retina and visual cortex to rat brains of different ages; maturation, connection patterns, and immunological consequences, Ann. N.Y. Acad. Sci., 495:227.

    Article  PubMed  CAS  Google Scholar 

  • Lund, R.D., Radel., J.D., Hankin, M.H., Klassen, H., Coffey, P.J., and Rawlins, J.N.P., in press, Development and functional integration of retinal transplants with host rat brains, in: “Brain Repair,” A. Bjorklund, A. Aguayo, and D. Ottoson, eds., Macmillan Press, London.

    Google Scholar 

  • McCaffery, C.A., Bennett, M.R., and Dreher, B., 1982, The survival of neonatal ganglion cells in vitro is enhanced in the presence of appropriate parts of the brain, Exp. Brain Res., 48:377.

    Article  PubMed  CAS  Google Scholar 

  • McLoon, S.C., and Lund, R.D., 1980, Specific projections of retina transplanted to rat brain, Exp. Brain Res., 40:273.

    Article  PubMed  CAS  Google Scholar 

  • Mustari, M.J., Lund, R.D., and Graubard, K., 1979, Histogenesis of the superior colliculus of the albino rat: a tritiated thymidine study, Brain Res., 164:39.

    Article  PubMed  CAS  Google Scholar 

  • Nurcombe, V., and Bennett, M.R., 1981, Embryonic chick retinal ganglion cells identified in vitro: their survival is dependent on a factor from the Res., 44:249.

    CAS  Google Scholar 

  • Perry, V.H., Morris, R.J., and Raisman, G., 1984, Is Thy-1 expressed only by ganglion cells and their axons in the retina and optic nerve?, J. Neurocytol., 13:809.

    Article  PubMed  CAS  Google Scholar 

  • Perry, V.H., Lund, R.D., and McLoon, S.C., 1985, Ganglion cells in retinae transplanted to newborn rats, J. Comp. Neurol., 231:353.

    Article  PubMed  CAS  Google Scholar 

  • Pruss, R.M., 1979, Thy-1 antigen on long-term cultures of rat central nervous system, Nature, 280:688.

    Article  PubMed  CAS  Google Scholar 

  • Radel, J.D., Hankin, M.H., and Lund, R.D., 1989, Selectivity of connections made by retinal transplants, Soc. Neurosci. Abstr., 15:1367.

    Google Scholar 

  • Rager, G., S. Lausmann, and F. Gallyas, 1979, An improved silver stain for developing nervous tissue, Stain Technol., 54:193.

    PubMed  CAS  Google Scholar 

  • Ramóny Cajal, S., 1937, “Recollections of My Life,” American Philosophical Society, Philadelphia.

    Google Scholar 

  • Robb, M., Silver, J. and Sullivan, R., 1978, Ocular retardation (or) in the mouse. Invest. Ophthalmol. Vis. Sci., 17:468.

    CAS  Google Scholar 

  • Schlosshauer, B., Schwarz, U., and Rutishauser, U., 1984, Topological distribution of different forms of neural cell adhesion molecule in the developing chick visual system, Nature, 310:141.

    Article  PubMed  CAS  Google Scholar 

  • Sefton, A.J., and Lund, R.D., 1988, Cotransplantation of embryonic mouse retinal with tectum, diencephalon, or cortex to neonatal rat cortex, J. Comp. Neurol., 269:548.

    Article  PubMed  CAS  Google Scholar 

  • Silver, J. and Robb, R.M., 1979, Studies on the development of the eye cup and optic nerve in normal mice and in mutants with congenital optic nerve aplasia, Dev. Biol., 68:175.

    Article  PubMed  CAS  Google Scholar 

  • Silver, J., and Rutishauser, U., 1984, Guidance of optic axons in vivo by a preformed adhesive pathway on neuroepithelial end-feet, Dev. Biol., 106:485.

    Article  PubMed  CAS  Google Scholar 

  • Simons, D.J., and Lund, R.D., 1985, Fetal retinae transplanted over tecta of neonatal rats respond to light and evoke patterned neuronal discharges in the superior colliculus, Dev. Brain Res., 21:156.

    Article  Google Scholar 

  • Straznicky, K., and Gaze, R.M., 1972, The development of the tectum in Xenopus laevis: an autoradiographic study, J. Embryol. Exp. Morphol., 28:87.

    PubMed  CAS  Google Scholar 

  • Tessier-Lavigne, M., Placzek, M., Lumsden, A.G.S., Dodd, J., and Jessell, T.M., 1988, Chemotropic guidance of developing axons in the mammalian central nervous system, Nature, 336:775.

    Article  PubMed  CAS  Google Scholar 

  • Theiler, K., Varnum, D.S., Nadeau, J.H., Stevens, L.C. and Cagianut, B., 1976, A new allele of ocular retardation: early development and morphogenetic cell death, Anat. Embryol (Berlin), 150:85.

    CAS  Google Scholar 

  • Turner, J.E., Barde, Y.-A., Schwab, M.E., and Thoenen, H., 1983, Extract from brain stimulates neunte outgrowth from fetal rat retinal explants, Dev. Brain Res., 6:77.

    Article  Google Scholar 

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© 1990 Plenum Press, New York

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Hankin, M., Lund, R. (1990). In Vivo Correlates of In Vitro Studies of Axonal Guidance: Retinal Transplantation in the Mammalian Retinotectal System. In: Raymond, P.A., Easter, S.S., Innocenti, G.M. (eds) Systems Approaches to Developmental Neurobiology. NATO ASI Series, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7281-3_9

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  • DOI: https://doi.org/10.1007/978-1-4684-7281-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7283-7

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