Abstract
The brain of a vertebrate contains in one cubic millimeter about 105 neurones, 109 times more than this in the number of synapses, and about a kilometre in the length of axons and dendrites. The neurones, axons, dendrites and synapses are arranged and connected in a highly specific and ordered manner, though relatively little is known about how this complicated system develops. Developing connections between neurones are established via the neuronal growth cone, which has to navigate through an environment crowded with cellular and extra-cellular signals. The growth cone is a structure exquisitely designed for motility and this environmental exploration; it possesses a dynamic cytoskeleton and surface molecules essential for its recognition of, and recognition by, target cells.
This chapter to be cited as: Allsopp, T., and Bonhoeffer, F., 1990, In vivo and in vitro guidance of axons, in: “Systems Approaches to Developmental Neurobiology,” P. A. Raymond, S. S. Easter, Jr., and G. M. Innocenti, eds., Plenum Press, New York.
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© 1990 Plenum Press, New York
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Allsopp, T., Bonhoeffer, F. (1990). In Vivo and In Vitro Guidance of Axons. In: Raymond, P.A., Easter, S.S., Innocenti, G.M. (eds) Systems Approaches to Developmental Neurobiology. NATO ASI Series, vol 192. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7281-3_7
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