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Antiviral Drug Development pp 149–172Cite as

Animal Models as Assay Systems for the Development of Antivirals

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Part of the book series: NATO ASI Series ((NSSA,volume 143))

Abstract

The importance of experimental viral infections in animal models for development and testing of new antiviral agents prior to their use in man should not be understated. While tissue culture systems are of great value in determining if a new drug has activity against a particular virus, these systems should not be used as indicators or predictors of activity in humans. Only where suitable animal models are not available, should a compound be taken from tissue culture directly into human trials. Although one can legitimately argue that most, if not all, animal model infections are not identical to the human disease, it can be demonstrated that a compound does in fact have activity in an in vivo system and early indications of its antiviral activity, tissue distribution, metabolic disposition, pharmacokinetics, and acute toxicity can be realized. Importantly, all of these parameters of drug pharmacodynamics can be correlated with inhibition of viral replication in target organs. Additionally, our understanding of the pathogenesis of many viral infections, the response of the host to infection and interaction between the infection, the host’s response, and a therapeutic agent has been enhanced greatly through the use of animal model systems.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, 84132, USA

    Earl R. Kern

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  1. Earl R. Kern
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Editors and Affiliations

  1. Katholieke Universiteit Leuven, Leuven, Belgium

    Erik De Clercq

  2. The University of Birmingham, Birmingham, UK

    Richard T. Walker

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© 1988 Plenum Press, New York

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Kern, E.R. (1988). Animal Models as Assay Systems for the Development of Antivirals. In: De Clercq, E., Walker, R.T. (eds) Antiviral Drug Development. NATO ASI Series, vol 143. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7275-2_10

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