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Urolithiasis and Related Clinical Research pp 233–236Cite as

Glyoxylate Oxidation and Enzymes of Oxalate Biosynthesis in Thiamine-Deficient Rats

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Abstract

Glyoxylic acid (GA) is the major precursor of endogenous oxalate and is mainly derived from glycine, glycolate and hydroxyproline. It can be either converted to C02 in liver and kidney mitochondria by TPP-dependent α-ketoglutarate:GA carboligase1 and via the glyoxylate oxidation cycle2, or it can be oxidized to oxalate by glycolic acid oxidase (GAO) and lactate dehydrogenase (LDH). Thiamine deficiency leads to excessive accumulation of GA in tissues and its increased excretion in urine3,4 and may result in a greater incidence of renal calculi5,6. There are, however, contradictory reports on the effect of thiamine deficiency on oxalate excretion7,8. The present study tries to elucidate the biochemical cause of the hyperoxaluria in thiamine deficiency.

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Author information

Authors and Affiliations

  1. Dept. of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    S. K. Thind, H. Sidhu & R. Nath

Authors
  1. S. K. Thind
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  2. H. Sidhu
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  3. R. Nath
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Editor information

Editors and Affiliations

  1. University Hospital, Erlangen, Federal Republic of Germany

    Paul O. Schwille

  2. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  3. The General Infirmary, Leeds, England

    William G. Robertson

  4. University Hospital, Bonn, Federal Republic of Germany

    Winfried Vahlensieck

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© 1985 Plenum Press, New York

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Thind, S.K., Sidhu, H., Nath, R. (1985). Glyoxylate Oxidation and Enzymes of Oxalate Biosynthesis in Thiamine-Deficient Rats. In: Schwille, P.O., Smith, L.H., Robertson, W.G., Vahlensieck, W. (eds) Urolithiasis and Related Clinical Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7272-1_45

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  • DOI: https://doi.org/10.1007/978-1-4684-7272-1_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7274-5

  • Online ISBN: 978-1-4684-7272-1

  • eBook Packages: Springer Book Archive

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