Abstract
In 1966 Ash and Schild1 pointed out for the first time the existence of different types of histamine receptors. They defined as H1 receptors those which could be blocked by the classical antihistaminics and non-H1 receptors those which could not be blocked. However, a real milestone in the history of histamine was represented by the paper of Black and coworkers2 entitled “Definition and antagonism of histamine H2 receptors” in which the first H2 receptor antagonist, burimamide, was described. The subsequent availability of rather selective H2 receptor stimulants and inhibitors, which served as a tool for characterizing H1 and H2 receptors, contributed noticeably to clarifying the role of histamine in gastric secretion.
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References
Ash, ASF, Schild HO: Receptors mediating some actions of histamine. Br J Pharmac 27: 427–439, 1966
Black JW, Duncan WAM, Durant CJ, et al: Definition and antagonism of histamine H2-receptors. Nature 236: 385–390, 1972
Bertaccini G, Impicciatore M: Activity of 2-(5-methyl-4-imida-zolyl)-ethylamine (5-methylhistamine) on the gastric secretion of different laboratory animals and of man. Eur J Pharmacol 28: 360–367, 1974
Bertaccini G, Impicciatore M, Vitali T: Biological activities of a new specific stimulant of histamine H2-receptors. Il Farmaco Ed Sc 31: 935–938, 1976
Impicciatore M, Bertaccini G, Mossini F, et al: N-methyl, 5-methyl histamine evokes higher maximal rate of gastric acid secretion than histamine. Clin Res 25: 109A, 1977
Carter DC, Grossman MI: Dimaprit evokes higher maximal rates of gastric secretion than histamine. Gastroenterology 72: 1036, 1977
Durant GJ, Emmett JC, Ganellin CR, et al: Potential histamine H2 receptor antagonists. 3 methyl histamines. J Med Chim 19: 923–928, 1976
Wood CJ, Simkins MA: International symposium on histamine H2-receptor antagonists. Smith Kline and French Laboratories Ltd. Welwyn Garden City, 1973
Burland WL, Simkins AM: Cimetidine. International symposium on histamine H2-receptor antagonists. Excerpta Medica; Amsterdam-Oxford, 1976
Soll A, Isolated mammalian parietal cells: effects of atropine and metiamide on the actions and interactions of secretago-gues, Gastroenterology 72: 824, 1977
Ivey KJ, Baskin W, Jeffrey G: Effect of Cimetidine on gastric potential difference in man. Lancet 2: 1072–1073, 1975
Haas HL, Bucker UM: Histamine H2-receptors on single central neurones. Nature 255: 634–635, 1975
Fleish JH, Calkins PJ: Comparison of drug-induced responses of rabbit trachea and bronchus. J Appl Physiol 41: 62–66, 1976
Calcutt CR, Reynolds J: Some behavioral effects following intracerebroventricular (ICV) injection in rats of histamine H1-receptor and H2-receptor agonists and antagonists. Neurosci L. 3: 82–83, 1976
Dai S: A study of the actions of histamine on the isolated rat heart. Clin Exp Pharmacol Physiol 3: 359–367, 1976
Clark RAF, Sandler JA, Gallin JI, et al: Histamine modulation of eosinophil migration. J Immunol 118: 137–145, 1977
Bertaccini G, Coruzzi G, Molina E, et al: Action of histamine and related compounds on the pyloric sphincter of the rat. (unpublished)
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© 1978 Plenum Press, New York
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Bertaccini, G. (1978). Histamine H2-Receptors and Gastric Secretion. In: Grossman, M., Speranza, V., Basso, N., Lezoche, E. (eds) Gastrointestinal Hormones and Pathology of the Digestive System. Advances in Experimental Medicine and Biology, vol 106. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7248-6_8
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DOI: https://doi.org/10.1007/978-1-4684-7248-6_8
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