Peptidergic Innervation of the Gastrointestinal Tract

  • J. M. Polak
  • S. R. Bloom
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


The presence of peptides in gut endocrine cells has been recognised for more than a decade but only in the last few years has it become increasingly apparent that several of these peptides are also found in the central and autonomic nervous system. In fact, the recognition that peptides can occur in at least 2 types of tissue is considerably older and dates from the discovery1 that the same peptide (substance P) could be extracted from both brain and gut. The list of these peptides found in both brain and gut is probably not yet complete but at present comprises VIP, CCK/ gastrin, neurotensin, somatostatin, bombesin, substance P, and enkephalin. In the gut mucosa these peptides may be found either in typical endocrine cells, where they may act as circulating or local hormones, or in the autonomic nerves. Here they may function as neurotransmitters or they may modify the responses of other cells by stimulation or inhibition.


Endocrine Cell Myenteric Plexus Hypertrophic Pyloric Stenosis Peptidergic Neuron Peptidergic Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. M. Polak
    • 1
  • S. R. Bloom
    • 1
  1. 1.Departments of Histochemistry and Medicine, The Royal Postgraduate Medical SchoolHammersmith HospitalLondonEngland

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