Roles of the Vagus in Endogenous Release of Secretin and Exocrine Pancreatic Secretion in Dog

  • K. Y. Lee
  • W. Y. Chey
  • H. H. Tai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


It has been well established that secretin1 is released from upper small intestinal mucosa in response to hydrogen ion delivered in the duodenum in man 2 and dog.3 As pH of the proximal duodenum decreased below 4.0 during the postprandial period, plasma secretin concentration increased significantly in man.4 We investigated a possible role of the vagus nerve in release of endogenous secretin in conscious dogs as well as anesthetized dogs.


Pancreatic Fistula Pancreatic Secretion Exocrine Pancreatic Secretion Gastric Fistula Bicarbonate Secretion 
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  1. 1.
    Bayliss WM, Starling EH: The mechanism of pancreatic secretion. J Physiol 28: 325–353, 1902PubMedGoogle Scholar
  2. 2.
    Rhodes RA, Tai HH, Chey WY: Observations on plasma secretin levels by radioimmunoassay in response to duodenal acidification and to a meat meal in humans. Amer J Digest Dis 21: 873–879, 1976CrossRefGoogle Scholar
  3. 3.
    Lee KY, Tai HH, Chey WY: Plasma secretin and gastrin responses to a meat meal and duodenal acidification in dogs. Am J Physiol 230: 784–789, 1976PubMedGoogle Scholar
  4. 4.
    Chey WY, Hendricks J, Tai HH: Plasma secretin in fasting and postprandial state in man. Gastroenterology 72: 1156, 1977Google Scholar
  5. 5.
    Herrera F, Kemp DR, Tsukamoto M, Woodward ER, Dragstedt LR: A new cannula for study of pancreatic function. J Appl Physiol 25: 207–209, 1968PubMedGoogle Scholar
  6. 6.
    Tai HH, Chey WY: Simultaneous immunoassay of secretin and gastrin. Anal Biochem 74: 12–24, 1976PubMedCrossRefGoogle Scholar
  7. 7.
    Debas HT, Konturek SJ, Grossman MI: Effect of extragastric and truncal vagotomy on pancreatic secretion in the dog. Am J Physiol 228: 1173–1177, 1975Google Scholar
  8. 8.
    Konturek SJ, Tasler J and Obtulowiczw: Effect of atropine on pancreatic response to endogenous and exogenous secretin. Am J Digest Dis 16: 385–394, 1971PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • K. Y. Lee
    • 1
  • W. Y. Chey
    • 1
  • H. H. Tai
    • 1
  1. 1.The Isaac Gordon Center for Digestive Diseases and the Department of MedicineGenesee Hospital and University of Rochester School of Medicine and DentistryRochesterUSA

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