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Gastrointestinal Hormones and Pathology of the Digestive System pp 211–216Cite as

Roles of the Vagus in Endogenous Release of Secretin and Exocrine Pancreatic Secretion in Dog

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 106))

Abstract

It has been well established that secretin1 is released from upper small intestinal mucosa in response to hydrogen ion delivered in the duodenum in man 2 and dog.3 As pH of the proximal duodenum decreased below 4.0 during the postprandial period, plasma secretin concentration increased significantly in man.4 We investigated a possible role of the vagus nerve in release of endogenous secretin in conscious dogs as well as anesthetized dogs.

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References

  1. Bayliss WM, Starling EH: The mechanism of pancreatic secretion. J Physiol 28: 325–353, 1902

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  2. Rhodes RA, Tai HH, Chey WY: Observations on plasma secretin levels by radioimmunoassay in response to duodenal acidification and to a meat meal in humans. Amer J Digest Dis 21: 873–879, 1976

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  3. Lee KY, Tai HH, Chey WY: Plasma secretin and gastrin responses to a meat meal and duodenal acidification in dogs. Am J Physiol 230: 784–789, 1976

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  4. Chey WY, Hendricks J, Tai HH: Plasma secretin in fasting and postprandial state in man. Gastroenterology 72: 1156, 1977

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  5. Herrera F, Kemp DR, Tsukamoto M, Woodward ER, Dragstedt LR: A new cannula for study of pancreatic function. J Appl Physiol 25: 207–209, 1968

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  6. Tai HH, Chey WY: Simultaneous immunoassay of secretin and gastrin. Anal Biochem 74: 12–24, 1976

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  7. Debas HT, Konturek SJ, Grossman MI: Effect of extragastric and truncal vagotomy on pancreatic secretion in the dog. Am J Physiol 228: 1173–1177, 1975

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  8. Konturek SJ, Tasler J and Obtulowiczw: Effect of atropine on pancreatic response to endogenous and exogenous secretin. Am J Digest Dis 16: 385–394, 1971

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Author information

Authors and Affiliations

  1. The Isaac Gordon Center for Digestive Diseases and the Department of Medicine, Genesee Hospital and University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

    K. Y. Lee, W. Y. Chey & H. H. Tai

Authors
  1. K. Y. Lee
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  2. W. Y. Chey
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  3. H. H. Tai
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Editor information

Editors and Affiliations

  1. Veterans Administration, Wadsworth Hospital Center, Los Angeles, California, USA

    Morton Grossman

  2. Institute of 3rd Surgical Pathology, University of Rome, Italy

    V. Speranza , N. Basso  & E. Lezoche ,  & 

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© 1978 Plenum Press, New York

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Lee, K.Y., Chey, W.Y., Tai, H.H. (1978). Roles of the Vagus in Endogenous Release of Secretin and Exocrine Pancreatic Secretion in Dog. In: Grossman, M., Speranza, V., Basso, N., Lezoche, E. (eds) Gastrointestinal Hormones and Pathology of the Digestive System. Advances in Experimental Medicine and Biology, vol 106. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7248-6_27

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  • DOI: https://doi.org/10.1007/978-1-4684-7248-6_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7250-9

  • Online ISBN: 978-1-4684-7248-6

  • eBook Packages: Springer Book Archive

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