The Glucagonoma Syndrome

  • S. R. Bloom
  • J. M. Polak
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


Although there had been a number of previous reports of non-β cell tumours of the pancreas, some of which might have been producing glucagon, the first report with proper measurement of glucagon levels did not appear until 1966.1 The collection of clinical details from 9 separate glucagonoma patients in 19742 made it possible to delineate the clinical features common to all cases and thus allowed us to report the existence of a “glucagonoma syndrome.” The main features in this were a characteristic rash, necrolytic and migratory erythema, painful glossitis, angular stomatitis, normochromic normocytic anaemia, severe weight loss, diabetes mellitus and the symptoms of a pancreatic tumour. It is of interest that following this description a considerable number of further case reports have appeared reiterating these features.3–11 Presumably such cases were previously overlooked; this demonstrates the benefit of a proper clinical description.


Glucagon Level Pancreatic Endocrine Tumour Migratory Erythema Severe Weight Loss Normochromic Normocytic Anaemia 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • S. R. Bloom
    • 1
  • J. M. Polak
    • 1
  1. 1.Departments of Medicine and Histochemistry, The Royal Postgraduate Medical SchoolHammersmith HospitalLondonEngland

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