Gastric-Glucagon: Physiology and Pathology

  • P. J. Lefebvre
  • A. S. Luyckx
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


As recently reported by several groups of investigators1-3, the plasma of totally depancreatized dogs contains normal, or even increased, quantities of a material immunometrically indistinguishable from pancreatic glucagon by radioimmunoassays regarded as highly specific for this hormone. As emphasized by Sasaki et al.4, this post-pancreatectomy immunoreactivity cannot be attributed to a cross-reaction with high levels of “gut glucagon-like immunoreactivity”, a group of immunometrically dissimilar polypeptides whose level is not elevated after pancreatectomy5. However, glucagon cannot be detected in the blood of dogs that have undergone complete abdominal evisceration . Therefore, in the dog, the origin of extrapancreatic glucagon is likely to be an abdominal organ; other significant sources of glucagon, such as the salivary glands as reported in the rodents 7,8, are unlikely to exist.


Glucagon Secretion Plasma Glucagon Glucagon Release Pancreatic Glucagon Arginine Infusion 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • P. J. Lefebvre
    • 1
  • A. S. Luyckx
    • 1
  1. 1.Division of Diabetes, Institute of MedicineUniversity of LiègeLiègeBelgium

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