Pancreatic Polypeptide (PP)
During purification of insulin a new hormone named pancreatic polypeptide (PP) was isolated independently by Kimmel (avian PP) and Chance2 (human, bovine, porcine, ovine and canine PP). PP is a 36 amino-acid straight chain polypeptide, with no apparent similarity in sequence with any known hormone. Only one or two aminoacids distinguish mammalian PP’s, whereas they have about 16 aminoacids in common with the avian counterpart.
KeywordsVagal Stimulation Pancreatic Secretion Pancreatic Polypeptide Pancreatic Polypeptide Cell Pancreatic Polypeptide Level
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- 2.Chance RE, Johnson MG, Koffenberger Jr JE, et al: Isolation and amino acid sequence of a new pancreatic polypeptide. UnpublishedGoogle Scholar
- 5.Lin TM, Chance RE: Gastrointestinal actions of a new bovine pancreatic peptide (BPP). In Endocrinology of the gut. WY Chey and FP Brooks, editor. Thorofare, New Jersey. 1: 143–145, 1974Google Scholar
- 7.Floyd JC, Fajans SS, Pek S, Chance RE: A newly recognized pancreatic polypeptide; plasma levels in health and disease. Rec Progr Horm Res, 1977Google Scholar
- 10.Schwartz TW, Holst JJ, Lindkaer Jensen S, et al: XIth Acta Endocrinologia Congress, abstract, 1977Google Scholar
- 12.Schwartz TW, Stenquist S, Olbe L: Vagal influence on pancreatic polypeptide secretion. In “International Gut Hormone Symposium”, SR Bloom, ed, 1977Google Scholar