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Pancreatic Polypeptide (PP)

  • T. W. Schwartz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)

Abstract

During purification of insulin a new hormone named pancreatic polypeptide (PP) was isolated independently by Kimmel (avian PP) and Chance2 (human, bovine, porcine, ovine and canine PP). PP is a 36 amino-acid straight chain polypeptide, with no apparent similarity in sequence with any known hormone. Only one or two aminoacids distinguish mammalian PP’s, whereas they have about 16 aminoacids in common with the avian counterpart.

Keywords

Vagal Stimulation Pancreatic Secretion Pancreatic Polypeptide Pancreatic Polypeptide Cell Pancreatic Polypeptide Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kimmel JR, Hayden LJ, Pollock HG: Isolation and characterization of a new pancreatic polypeptide hormone. J Biol Chem 250: 9369–9376, 1975PubMedGoogle Scholar
  2. 2.
    Chance RE, Johnson MG, Koffenberger Jr JE, et al: Isolation and amino acid sequence of a new pancreatic polypeptide. UnpublishedGoogle Scholar
  3. 3.
    Larsson LI, Sundler F, Håkanson R: Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells. Cell Tiss Res 156: 167–171, 1975CrossRefGoogle Scholar
  4. 4.
    Larsson LI, Sundler F, Håkanson R: Pancreatic polypeptide — a postulated new hormone: Identification of its cellular storage site by light and electron microscopic immunocytochemistry. Diabetologia 12: 211–226, 1976PubMedCrossRefGoogle Scholar
  5. 5.
    Lin TM, Chance RE: Gastrointestinal actions of a new bovine pancreatic peptide (BPP). In Endocrinology of the gut. WY Chey and FP Brooks, editor. Thorofare, New Jersey. 1: 143–145, 1974Google Scholar
  6. 6.
    Lin TM, Evans DC, Chance RE, et al: Bovine pancreatic peptide: Action on gastric and pancreatic secretion in dogs. Am J Physiol 232 (3): E311–E315, 1977PubMedGoogle Scholar
  7. 7.
    Floyd JC, Fajans SS, Pek S, Chance RE: A newly recognized pancreatic polypeptide; plasma levels in health and disease. Rec Progr Horm Res, 1977Google Scholar
  8. 8.
    Schwartz TW, Rehfeld, JF, Stadil F, et al: Pancreatic-polypeptide response to food in duodenal-ulcer patients before and after vagotomy. Lancet I: 1102–1105, 1976CrossRefGoogle Scholar
  9. 9.
    Adrian TE, Bloom SR, Besterman HS, et al: Mechanism of pancreatic polypeptide release in man. Lancet I: 161–163, 1977CrossRefGoogle Scholar
  10. 10.
    Schwartz TW, Holst JJ, Lindkaer Jensen S, et al: XIth Acta Endocrinologia Congress, abstract, 1977Google Scholar
  11. 11.
    Schwartz TW, Rehfeld JF: Mechanism of pancreatic-polypeptide release. Lancet I: 697–698, 1977CrossRefGoogle Scholar
  12. 12.
    Schwartz TW, Stenquist S, Olbe L: Vagal influence on pancreatic polypeptide secretion. In “International Gut Hormone Symposium”, SR Bloom, ed, 1977Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • T. W. Schwartz
    • 1
  1. 1.Institute of Medical BiochemistryUniversity of AarhusDenmark

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