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A Short History of Digestive Endocrinology

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Gastrointestinal Hormones and Pathology of the Digestive System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 106))

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Abstract

In digestive endocrinology, as in other branches of science, most of the contributions have stemmed from a few epoch-making discoveries:

  1. 1

    PHYSIOLOGICAL ORIGINS. On January 16, 1902, Bayliss and Starling1 performed what they quite appropriately perceived to be “the crucial experiment” showing that putting acid into the jejunum still stimulated pancreatic secretion after all nervous connections between the two organs had been cut. Correctly deducing what the nature of the non-nervous mechanism must be, they made an extract of jejunal mucosa and showed that it stimulated pancreatic secretion when given intravenously whereas an extract of ileal mucosa did not. Bayliss and Starling recognized that they had not only discovered a new substance, secretin, but had also introduced a new concept, the regulation of bodily activities by blood borne chemical messengers or hormones. And thus was born the science of endocrinology in general as well as digestive endocrinology in particular. In due course, almost every digestive function was studied to determine whether it might have an endocrine component in its regulation.

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Author information

Authors and Affiliations

  1. Veterans Administration, Wadsworth Hospital Centre, Los Angeles, California, USA

    M. I. Grossman

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  1. M. I. Grossman
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Editors and Affiliations

  1. Veterans Administration, Wadsworth Hospital Center, Los Angeles, California, USA

    Morton Grossman

  2. Institute of 3rd Surgical Pathology, University of Rome, Italy

    V. Speranza , N. Basso  & E. Lezoche ,  & 

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© 1978 Plenum Press, New York

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Grossman, M.I. (1978). A Short History of Digestive Endocrinology. In: Grossman, M., Speranza, V., Basso, N., Lezoche, E. (eds) Gastrointestinal Hormones and Pathology of the Digestive System. Advances in Experimental Medicine and Biology, vol 106. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7248-6_2

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  • DOI: https://doi.org/10.1007/978-1-4684-7248-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7250-9

  • Online ISBN: 978-1-4684-7248-6

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